Cryomyolysis, a new procedure for the conservative treatment of uterine fibroids

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dc.contributor.author Zreik, Tony
dc.contributor.author Rutherford, Thomas
dc.contributor.author Patler, Steven
dc.contributor.author Troiano, Robert
dc.contributor.author Williams, Ena
dc.contributor.author Brown, Janis
dc.contributor.author Olive, David
dc.date.accessioned 2015-10-06T06:44:46Z
dc.date.available 2015-10-06T06:44:46Z
dc.date.copyright 1998
dc.date.issued 2016-05-17
dc.identifier.issn 1074-3804 en_US
dc.identifier.uri http://hdl.handle.net/10725/2253
dc.description.abstract Conservative surgical options for uterine myomata traditionally were abdominal myomectomy, laparoscopic myomectomy, and, more recently, myolysis. Each of these procedures has distinct advantages, but also apparent disadvantages. We attempted to introduce an additional option for conservative surgical treatment of fibroids by freezing the structures, a procedure termed cryomyolysis. In this pilot study, 14 women were pretreated with a gonadotropin-releasing hormone (GnRH) agonist for a minimum of 2 months preoperatively to minimize uterine and myoma size. Cryomyolysis was performed and the GnRH agonist was discontinued. Magnetic resonance imaging scans were performed in 10 of the 14 women after GnRH agonist treatment but before surgery, and 4 months postoperatively. Total uterine volume ranged from 41.3 to 1134.8 ml preoperatively, and 49.5 to 1320 ml postoperatively (mean increase 22% after discontinuation of GnRH agonist). Normal uterine volume ranged from 35.6 to 548.7 ml preoperatively and 45.1 to 729.6 ml postoperatively (mean increase 40%); however, myoma volume showed a mean decrease of 6% (range-87-28%). Analysis of only frozen myomata revealed a mean volume decrease of 10%. Cryomyolysis maintains at or slightly reduces these lesions to post-GnRH agonist size, and all other uterine tissue returns to pretreatment size. We believe cryomyolysis may be an effective conservative surgical approach to uterine fibroids. en_US
dc.language.iso en en_US
dc.title Cryomyolysis, a new procedure for the conservative treatment of uterine fibroids en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 200802707
dc.author.woa N/A en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal The Journal of the American Association of Gynecologic Laparoscopists en_US
dc.journal.volume 5 en_US
dc.journal.issue 1 en_US
dc.article.pages 33-38 en_US
dc.identifier.doi http://dx.doi.org/10.1016/S1074-3804(98)80008-X en_US
dc.identifier.ctation Zreik, T. G., Rutherford, T. J., Palter, S. F., Troiano, R. N., Williams, E., Brown, J. M., & Olive, D. L. (1998). Cryomyolysis, a new procedure for the conservative treatment of uterine fibroids. The Journal of the American Association of Gynecologic Laparoscopists, 5(1), 33-38. en_US
dc.author.email tgzreik@lau.edu.lb
dc.identifier.url http://www.sciencedirect.com/science/article/pii/S107438049880008X

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