Lymph Node Ratio Is an Independent Prognostic Factor After Resection of Periampullary Malignancies

LAUR Repository

Show simple item record

dc.contributor.author Dimassi, Hani
dc.contributor.author Shamseddine, Ali
dc.contributor.author Mukherji, Deborah
dc.contributor.author Melki, Christian
dc.contributor.author Elias, Elias
dc.contributor.author Eloubeidi, Mohammad
dc.date.accessioned 2015-10-02T08:34:16Z
dc.date.available 2015-10-02T08:34:16Z
dc.date.copyright 2014
dc.date.issued 2015-10-02
dc.identifier.issn 0277-3732 en_US
dc.identifier.uri http://hdl.handle.net/10725/2240
dc.description.abstract Objective: The prognostic impact of nodal involvement in resected pancreatic carcinoma and biliary malignancy has been relatively well established. It has been suggested that lymph node ratio (LNR) may be a more informative way of stratifying patients with node positive disease. Our retrospective review aimed to investigate the significance of such variables and test for independent prognostic factors for survival. Methods: One hundred eighty-three pancreatic and periampullary malignancy cases were registered at the American University of Beirut Medical Center from 1990 to 2004. Of those, 80 had complete data on lymph node status. We analyzed the impact of the number of lymph nodes resected, the number of positive lymph nodes retrieved and LNR using Kaplan-Meier and Cox proportional hazard models. The measured outcome in the KM model was the survival probability at 1, 3, and 5 years while the Cox model was used to measure the hazard ratio (HR) of the previously identified predictors on survival. Results: For the 80 patients included in this analysis, overall survival rates were 65% (54 to 78), 32% (18 to 47), and 21% (8 to 34) were alive at 1, 3, and 5 years, respectively. The median number of resected lymph nodes was 9. In the node positive patients, those who had >12 nodes examined were found to have a significantly better survival (HR=0.24; P=0.013). On multivariate analysis, our model showed the following factors to be significant: age 60 years or older (HR=5.92; P=0.018), poorly differentiated tumors (HR=21.87; P=0.018), number of lymph nodes examined <12 LN (HR=6.77; P=0.022), 3 or more metastatic LN (HR=7.21; P=0.028), and LNR≥0.2 (HR=7.12; P=0.007). Conclusions: After pancreaticodudonectomy for adenocarcinoma of the pancreas and biliary malignancies, ratio-based lymph node staging is an independent and powerful prognostic factor. en_US
dc.language.iso en en_US
dc.title Lymph Node Ratio Is an Independent Prognostic Factor After Resection of Periampullary Malignancies en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle Data From a Tertiary Referral Center in the Middle East en_US
dc.author.school SOP en_US
dc.author.idnumber 200603781
dc.author.woa N/A en_US
dc.author.department Pharmacy en_US
dc.description.embargo N/A en_US
dc.relation.journal American Journal of Clinical Oncology. en_US
dc.journal.volume 37 en_US
dc.journal.issue 1 en_US
dc.article.pages 13-18 en_US
dc.identifier.doi http://dx.doi.org/10.1097/COC.0b013e31826b9c74 en_US
dc.identifier.ctation Shamseddine, A. I., Mukherji, D., Melki, C., Elias, E., Eloubeidi, M., Dimassi, H., ... & Faraj, W. (2014). Lymph node ratio is an independent prognostic factor after resection of periampullary malignancies: data from a tertiary referral center in the middle East. American journal of clinical oncology, 37(1), 13-18. en_US
dc.author.email hani.dimassi@lau.edu.lb
dc.identifier.url http://journals.lww.com/amjclinicaloncology/Abstract/2014/02000/Lymph_Node_Ratio_Is_an_Independent_Prognostic.3.aspx

Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search LAUR

Advanced Search


My Account