Formulation Optimization Study for an Immediate-Release Tablet

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dc.contributor.author Dimassi, Hani
dc.contributor.author Kyriacos, Soula
dc.date.accessioned 2015-10-02T06:13:33Z
dc.date.available 2015-10-02T06:13:33Z
dc.date.copyright 2009
dc.date.issued 2015-10-02
dc.identifier.issn 1092-4221
dc.identifier.uri http://hdl.handle.net/10725/2236
dc.description.abstract A simple method based on statistical analysis was used to optimize an immediate-release tablet formulation that includes a water-soluble drug. The objective of this study was to optimize different factors to develop a tablet formulation that has good tablet characteristics (hardness of 85 to 90 Newtons), disintegration time between 3 to 6 minutes, and friability <1%. The critical formulation/process factors were the type and concentration of microcrystalline cellulose, the ratio of lactose to microcrystalline cellulose, the concentration of croscarmellose, and the compression force. A two-step approach was implemented. First an optimization study was performed to determine the type of microcrystalline cellulose and its ratio to lactose. Subsequently, a final optimization formulation study was performed based on the results obtained in the preliminary study. Data were analyzed using the SPSS 15 (Statistical Software for Social Sciences). The differences in means between the formulation and the targeted product en_US
dc.language.iso en en_US
dc.title Formulation Optimization Study for an Immediate-Release Tablet en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOP en_US
dc.author.idnumber 200603781
dc.author.woa N/A en_US
dc.author.department Pharmacy en_US
dc.description.embargo N/A en_US
dc.relation.journal International Journal of Pharmaceutical Compounding en_US
dc.journal.volume 13 en_US
dc.journal.issue 3 en_US
dc.article.pages 259-261 en_US
dc.keywords Water-soluble drug en_US
dc.keywords Immediate release en_US
dc.keywords Formulation development en_US
dc.keywords Excipients en_US
dc.identifier.ctation Kyriacos, S., & Dimassi, H. (2008). Formulation Optimization Study for an Immediate-Release Tablet. International journal of pharmaceutical compounding, 13(3), 259-261. en_US
dc.author.email hani.dimassi@lau.edu.lb
dc.identifier.url http://europepmc.org/abstract/med/23966482

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