Clinical correlates of white-matter abnormalities on head magnetic resonance imaging

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dc.contributor.author Dimassi, Hani
dc.contributor.author Lasbury, Nora
dc.contributor.author Garg, Bhuwan
dc.contributor.author Cowan, Linda D.
dc.contributor.author Edwards-Brown, Mary
dc.contributor.author Bodensteiner, John B.
dc.date.accessioned 2015-10-01T06:52:37Z
dc.date.available 2015-10-01T06:52:37Z
dc.date.copyright 2001
dc.date.issued 2015-10-01
dc.identifier.issn 0883-0738 en_US
dc.identifier.uri http://hdl.handle.net/10725/2226
dc.description.abstract We undertook this study to investigate the relationship between white-matter abnormalities (seen on brain magnetic resonance imaging [MRI]) and muscle tone and muscle stretch reflexes on clinical examination. We identified all patients less than 5 years of age who had undergone cranial MRI studies at Riley Hospital for Children between June 30, 1999, and July 1, 2000, whose scans were read as showing white-matter abnormalities. We measured two ratios and the thickness of the corpus callosum as indicators of the quantity of cerebral white matter. The ratios were R1, the ratio of the thickness of the white matter at the level just above the body of the lateral ventricle compared with the width of the hemisphere, and R2, the ratio of the thickness of the white matter to the width of the hemisphere at the level of the trigone of the lateral ventricle. The thickness of the corpus callosum was measured at the junction of the anterior two thirds and the posterior third. We also evaluated the signal intensity of the cerebral white matter by reviewing the fluid-attenuated inversion-recovery images and grading the signal as normal to severely abnormal depending on the degree and extent of high signal intensity seen (0 = normal to 4+). Thirty-eight children less than 5 years of age who underwent MRI scans between June and August 2000 and who were found to have normal tone prospectively and normal MRI scan on review served as a control group. We identified 215 patients who had white-matter abnormalities; of these, only 142 (66%) had documented tone assessments in their medical record. Our study group was divided into three groups: increased (n = 35), decreased (n = 53), and normal tone (n = 54). All three measurements of white matter in each of the three study groups were significantly below values for control children. The children with white-matter abnormalities and decreased tone had significantly less signal intensity abnormality than the other study groups. Children with white-matter abnormalities and increased tone had a greater frequency of increased reflexes and tended to have more signal abnormalities than the other groups. The group of children with white-matter abnormalities and normal tone had the least amount of cerebral white-matter deficiency of the three study groups. In patients with strikingly decreased quantities of cerebral white matter, those with normal signal-intensity white matter are likely to be hypotonic with normal reflexes and those with increased signal intensity in the white matter are likely to be spastic. (J Child Neurol 2001;16:668-672). en_US
dc.language.iso en en_US
dc.title Clinical correlates of white-matter abnormalities on head magnetic resonance imaging en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOP en_US
dc.author.idnumber 200603781
dc.author.woa N/A en_US
dc.author.department Pharmacy en_US
dc.description.embargo N/A en_US
dc.relation.journal Journal of Child Neurology en_US
dc.journal.volume 16 en_US
dc.journal.issue 9 en_US
dc.article.pages 668-672 en_US
dc.identifier.doi http://dx.doi.org/10.1177/088307380101600908 en_US
dc.identifier.ctation Lasbury, N., Garg, B., Edwards-Brown, M., Cowan, L. D., Dimassi, H., & Bodensteiner, J. B. (2001). Clinical correlates of white-matter abnormalities on head magnetic resonance imaging. Journal of child neurology, 16(9), 668-672. en_US
dc.author.email hani.dimassi@lau.edu.lb
dc.identifier.url http://jcn.sagepub.com/content/16/9/668.short

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