An evaluation of practice pattern for venous thromboembolism prevention in Lebanese hospitals

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dc.contributor.author Dimassi, Hani
dc.contributor.author Zeitoun, Abeer A.
dc.contributor.author El-Kary, Dania Y.
dc.contributor.author Akel, Marwan G.
dc.date.accessioned 2015-09-30T13:01:25Z
dc.date.available 2015-09-30T13:01:25Z
dc.date.issued 2015-09-30
dc.identifier.issn 0929-5305 en_US
dc.identifier.uri http://hdl.handle.net/10725/2223
dc.description.abstract Background Venous thromboembolism (VTE) is a major cause of death among hospitalized patients. Many VTE prophylaxis guidelines have been developed, including the American College of Chest Physicians (ACCP). VTE prophylaxis is required in specific patients; however, its practice is not always optimal, and often depends on the hospitals’ protocols. In Lebanon, information about the appropriateness of VTE prophylaxis in health care centers is lacking. Objective The primary objective of this study was to evaluate the pattern of VTE prophylaxis application, including agents, doses, duration of treatment, and route of administration, in Lebanese health care centers. Methods A Lebanese multi-center, prospective, chart review study was conducted over 4 months. Data on demographics, VTE prophylaxis medication, dose, route, duration, and associated risk factors were collected by pharmacy students. The appropriateness of VTE prophylaxis was determined as per ACCP guidelines. Patients receiving VTE treatment were excluded from the study. Institutional review board (IRB) approval was obtained from each hospital center. Results A total of 840 patients were included. Both gender groups were equally represented in the sample and the mean age was 59 ± 19.53 years. The majority (639/840, 76.1%) of the sample were at high risk for deep venous thrombosis (DVT), and inappropriate VTE prophylaxis was reported in 35% of the low-risk group, in 70% of the moderate-risk group, and in 39% of the high-risk group (P < 0.0001). Comparing proper VTE prophylaxis practice between intensive care unit (ICU) and non-ICU patients, there was no statistical difference observed in teaching hospitals (67.2% vs. 65.5%, P = 0.312). However, in non-teaching hospitals, appropriate VTE prophylaxis practice was more prevalent in ICU than non-ICU patients (65.9% vs. 51.2%, P = 0.004). The average duration of VTE prophylaxis was less than 10 days. Missing data was a major limitation for this study, where, for instance, the duration of prophylaxis could not be accurately abstracted in half of the sample. Another limitation was the absence of laboratory results needed for clinical assessment of the regimen used. Conclusion This study reflected the importance of assessing VTE prophylaxis in Lebanese hospitals, thus, the need for implementing established guidelines to improve the overall patient safety. en_US
dc.language.iso en en_US
dc.title An evaluation of practice pattern for venous thromboembolism prevention in Lebanese hospitals en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOP en_US
dc.author.idnumber 200603781
dc.author.woa N/A en_US
dc.author.department Pharmacy en_US
dc.description.embargo N/A en_US
dc.relation.journal Journal of thrombosis and thrombolysis en_US
dc.journal.volume 28 en_US
dc.journal.issue 2 en_US
dc.article.pages 192-199 en_US
dc.keywords VTE prophylaxis en_US
dc.keywords Lebanese population en_US
dc.keywords Appropriateness of VTE prophylaxis en_US
dc.keywords American College of Chest Physicians (ACCP) guideline en_US
dc.keywords Medication use evaluation (MUE) en_US
dc.keywords Multi-center design en_US
dc.identifier.doi http://dx.doi.org/10.1007/s11239-008-0298-7 en_US
dc.identifier.ctation Zeitoun, A. A., Dimassi, H. I., El Kary, D. Y., & Akel, M. G. (2009). An evaluation of practice pattern for venous thromboembolism prevention in Lebanese hospitals. Journal of thrombosis and thrombolysis, 28(2), 192-199. en_US
dc.author.email hani.dimassi@lau.edu.lb
dc.identifier.url http://link.springer.com/article/10.1007/s11239-008-0298-7

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