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The Candida albicans Hwp2 is necessary for proper adhesion, biofilm formation and oxidative stress tolerance

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dc.contributor.author Dimassi, Hani I.
dc.contributor.author Khalaf, Roy A.
dc.contributor.author Younes, Samer
dc.contributor.author Bahnan, Wael
dc.date.accessioned 2015-09-30T09:00:24Z
dc.date.available 2015-09-30T09:00:24Z
dc.date.copyright 2011
dc.date.issued 2015-09-30
dc.identifier.issn 0944-5013 en_US
dc.identifier.uri http://hdl.handle.net/10725/2217
dc.description.abstract Candida albicans is an important fungal pathogen of humans that is responsible for the majority of mucosal and systemic candidiasis. The host–pathogen interaction in C. albicans has been the subject of intense investigation as it is the primary step that leads to establishment of infection. Hwp2 is a cell wall GPI-anchored cell wall protein that was previously shown to be necessary for hyphal and invasive growth on solid media. The purpose of the current study is to further characterize the protein as far as its role in oxidative stress, sensitivity to cell wall disrupting agents, adhesion to human epithelial and endothelial cells, biofilm formation and chitin content. It appears that Hwp2 is necessary for proper oxidative stress tolerance, adhesion and biofilm formation as an hwp2 null is more susceptible to increasing doses of hydrogen peroxide, unable to adhere efficiently to epithelial and endothelial cell lines and unable to form wild type biofilm levels. en_US
dc.language.iso en en_US
dc.title The Candida albicans Hwp2 is necessary for proper adhesion, biofilm formation and oxidative stress tolerance en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOP en_US
dc.author.school SAS
dc.author.idnumber 200603781
dc.author.idnumber 200300427
dc.author.woa N/A en_US
dc.author.department Pharmacy en_US
dc.description.embargo N/A en_US
dc.relation.journal Microbiological research en_US
dc.journal.volume 166 en_US
dc.journal.issue 5 en_US
dc.article.pages 130-136 en_US
dc.keywords Candida albicans en_US
dc.keywords Biofilm en_US
dc.keywords Filamentation en_US
dc.keywords Adhesion en_US
dc.identifier.doi http://dx.doi.org/10.1016/j.micres.2010.08.004 en_US
dc.identifier.ctation Younes, S., Bahnan, W., Dimassi, H. I., & Khalaf, R. A. (2011). The Candida albicans Hwp2 is necessary for proper adhesion, biofilm formation and oxidative stress tolerance. Microbiological research, 166(5), 430-436. en_US
dc.author.email hani.dimassi@lau.edu.lb
dc.author.email roy.khalaf@lau.edu.lb
dc.identifier.url http://www.sciencedirect.com/science/article/pii/S0944501310000789


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