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Browsing SOM - Scholarly Publications by Author "Zalloua, Pierre A."

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Browsing SOM - Scholarly Publications by Author "Zalloua, Pierre A."

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  • Afghanistan's ethnic groups share a Y-chromosomal heritage structured by historical events 
    Haber, Marc; Platt, Daniel E.; Bonab, Maziar Ashrafian; Youhanna, Sonia C.; Soria-Hernanz, David F.; Martínez-Cruz, Begona; Douaihy, Bouchra; Ghassibe-Sabbagh, Michella; Rafatpanah, Hoshang; Ghanbari, Mohsen; Whale, John; Balanovsky, Oleg; Spencer Wells, R.; Comas, David; Tyler-Smith, Chris; Zalloua, Pierre A. (2019-07-25)
    Afghanistan has held a strategic position throughout history. It has been inhabited since the Paleolithic and later became a crossroad for expanding civilizations and empires. Afghanistan's location, history, and diverse ...
  • ALOX5AP gene variants show differential association with coronary artery disease in different populations 
    Alwan, Ahmad; Youhanna, Sonia C.; Platt, Daniel E.; El-Sibai, Mirvat; Yerezian, Joumana S.; Deeb, Mary E.; Khazen, Georges; Saade, Stephanie; Zreik, Tony G.; El Bayeh, Hamid; Maalouf, Assaad; Zalloua, Pierre A.; Abchee, Antoine (2015-12-17)
    Coronary artery disease (CAD) is a complex disease with various components, genetic as well as environmental. Previous reports correlating ALOX5AP gene variants and CAD showed conflicting results depending on the population ...
  • Association of waterpipe smoking with myocardial infarction and determinants of metabolic syndrome among catheterized patients 
    Platt, Daniel E.; Hariri, Essa; Salameh, Pascale; Helou, Mariana; Sabbah, Nada; Merhi, Mahmoud; Abchee, Antoine B.; Zalloua, Pierre A. (2019-06-03)
    Background: Waterpipe smoking is a rising global public health epidemic perceived by many users to be less harmful, though its toxicity overlaps or even exceeds that of cigarette smoking. Short-term cardiovascular changes ...
  • Characterization of a large Lebanese family segregating IgA nephropathy 
    Karnib, Hussein H.; Sanna-Cherchi, Simone; Zalloua, Pierre A.; Medawar, Walid; D'Agati, Vivette D.; Lifton, Richard P.; Badr, Kamal; Gharavi, Ali G. (2019-07-19)
    Background. Familial aggregation of IgA nephropathy (IgAN) suggests that genetic factors contribute to the development of this trait. Because clinical manifestations in IgAN families are often limited to episodic haematuria, ...
  • Chemical cleavage of 5′-linked protein from tobacco ringspot virus genomic RNAs and characterization of the protein–RNA linkage 
    Zalloua, Pierre A.; Buzayan, Jamal M.; Bruening, George (2019-07-19)
    Each of the two genomic RNAs of tobacco ringspot nepovirus is known to have a 5′-linked protein, the VPg. We report a simplified analysis of the covalent VPg-RNA connection that allowed us to identify the 5′ nucleotide ...
  • Circulating lipid levels and risk of coronary artery disease in a large group of patients undergoing coronary angiography 
    Deeb, Mary E.; Khazen, Georges; Zalloua, Pierre A.; Platt, Daniel E.; Ghassibe-Sabbagh, Michella; Cazier, Jean-Baptiste; Kamatani, Yoichiro; Salloum, Angelique K.; Hager, Jo¨rg; Youhanna, Sonia (2016-11-23)
    A main underlying pathology of coronary artery disease is the deposition of cholesterol in the arteries supplying blood to the heart that leads to stenosis and myocardial infarction. We tested if dyslipidemia is a risk ...
  • The codons 8/9 (+ G) mutation found for the first time in the Lebanese population 
    Zalloua, Pierre A.; Aoun, Elie; Koussa, Suzanne; Asfahani, Wissam S.Z.; Taher, Ali (2019-07-22)
    Thalassemia is a common inherited disease in the Mediterranean region. We here report a mutation new to the Lebanese population: the insertion of a G nucleotide at codons 8/9 [(+G) AAG‐TCT (Lys‐Ser)→AAG‐G‐TCT (β0)] of the ...
  • The DD genotype of the ACE gene polymorphism is associated with diabetic nephropathy in type-1 diabetics 
    Azar, Sami T.; Zalloua, Pierre A.; Medlej, Rita; Halabi, George (2019-07-19)
    Genetic factors are involved in the development of diabetic nephropathy in type-1 diabetes. We are examining the association of the angiotensin-converting enzyme (ACE), insertion/deletion (I/D) polymorphism with the presence ...
  • Development and evaluation of real-time polymerase chain reaction assays on whole blood and paraffin-embedded tissues for rapid diagnosis of human brucellosis 
    Zalloua, Pierre A.; Deeb, Mary; Kattara, Mireille M.; Araj, George F.; Samaha-Kfoury, Joumana; Shbakloe, Hadia; Kanj, Souha S.; Khalife, Simon (2016-11-18)
    This study aimed at developing a real-time polymerase chain reaction (PCR) assay for the rapid diagnosis of human brucellosis on clinical specimens. Three assays with hybridization probe detection on the LightCycler™ ...
  • Effective treatment of hypereosinophilic syndrome with imatinib mesylate 
    Salem, Ziad; Zalloua, Pierre A.; Chehali, Aref; Bitar, Nizar; Abboud, Miguel; kadri, Adel; Chami, Beatrice; Bazarbachi, Ali (2019-07-19)
    Imatinib mesylate treatment is highly effective in chronic myeloid leukaemia and recent data have suggested that imatinib mesylate is also effective in the treatment of idiopathic hypereosinophilicsyndrome (HES). Six ...
  • Genomic ancestry of North Africans supports back-to-Africa migrations 
    Henn, Brenna M.; Botigue, Laura R.; Gravel, Simon; Wang, Wei; Brisbin, Abra; Byrnes, Abra; Bymes, Jake K.; Fadhlaoui-Zid, Karina; Zalloua, Pierre A.; Moreno-Estrada, Andres; Bertranpetit, Jaume; Bustamante, Carlos D.; Comas, David (2019-07-19)
    North African populations are distinct from sub-Saharan Africans based on cultural, linguistic, and phenotypic attributes; however, the time and the extent of genetic divergence between populations north and south of the ...
  • Health system resilience 
    Ammar, Walid; Kdouh, Ola; Hammoud, Rawan; Hamadeh, Randa; Harb, Hilda; Ammar, Zeina; Atun, Rifat; Christiani, David; Zalloua, Pierre A. (2019-07-25)
    Background Between 2011 and 2013, the Lebanese population increased by 30% due to the influx of Syrian refugees. While a sudden increase of such magnitude represents a shock to the health system, threatening the continuity ...
  • Higher serum leptin level in women than in nen with type 1 diabetes 
    Azar, Sami T.; Salti, Ibrahim; Zantout, Mira S.; Shahine, Carmen H.; Zalloua, Pierre A. (2019-07-19)
    Leptin is the protein product of the obese (ob) gene, a lipostatic hormone that contributes to body weight regulation through suppressing appetite and/or stimulating energy expenditure in humans and/or rodents. In humans, ...
  • The I allele of the angiotensin converting enzyme I/D polymorphism confers protection against coronary artery disease 
    Abchee, Antoine; El-Sibai, Mirvat; Youhanna, Sonia; Yeretzian, Joumana S.; Hanine, Estephan; Makhoul, Nadine J.; Puzantian, Houry; Sawaya, Jaber; Nasrallah, Antoine; Rebeiz, Abdallah G.; Zreik, Tony G.; Azar, Sami T.; Zalloua, Pierre A. (2017-07-27)
    Background: Mutations in genes regulating lipid metabolism, vasoactivity, and coagulation are important modulators of coronary artery disease (CAD). Objective: This study investigated the association between allelic ...
  • Identifying genetic traces of historical expansions 
    Zalloua, Pierre A.; Platt, Daniel E.; El Sibai, Mirvat; Khalife, Jade; Makhoul, Nadine; Haber, Marc; Xue, Yali; Izaabel, Hassan; Bosch, Elena; Adams, Susan M.; Arroyo, Eduardo; Lopez-Parra, Ana Maria; Aler, Mercedes; Picornell, Antonia; Ramon, Misericordia; Jobling, Mark A.; Comas, David; Bertranpetit, Jaume; Tyler-Smith, Chris (2019-07-18)
    The Phoenicians were the dominant traders in the Mediterranean Sea two thousand to three thousand years ago and expanded from their homeland in the Levant to establish colonies and trading posts throughout the Mediterranean, ...
  • Impact of seafood and fruit consumption on bone mineral density 
    Zalloua, Pierre A.; Hsu, Yi-Hsiang; Terwedow, Henry; Zang, Tonghua; Tang, Genfu; Li, Zhiping; Hong, Xiumei; Azar, Sami T.; Wang, Binyan; Bouxsein, Mary L.; Brain, Joseph; Cummings, Steven R.; Rosen, Clifford J.; Xu, Xiping (2019-07-18)
    Objectives Over the past decade, dietary choices and nutrition have proven to be major modulators of bone mineral density (BMD) in men and women. We investigated environmental determinants, specifically dietary habits, ...
  • Improved quality of 1H NMR spectroscopic data for enhanced metabolic profiling of low molecular weight metabolites in human serum Authors Authors and affiliations 
    Stolzenburg, Svenja; Lauridsen, Micheal B.; Toft, Henrik; Zalloua, Pierre A.; Baunsgaard, Dorrit (2019-07-22)
    NMR based metabolic profiling of blood samples in epidemiological studies can be used for molecular phenotyping and biomarker discovery. Often metabolic changes in blood are more subtle and demand a high quality spectrum ...
  • Increase of satellite tobacco ringspot virus RNA initiated by inoculating circular RNA 
    Buzayan, Jamal M.; Tol, Hans Van; Zalloua, Pierre A.; Bruening, George (2019-07-19)
    A small satellite RNA of tobacco ringspot virus (sTRSV RNA) generates circular and linear molecules of unit length and repetitive sequence, linear multimers during replication. The phosphodiester junction joining the unit ...
  • Large-scale association analysis identifies new risk loci for coronary artery disease 
    Deloukas, Panos; Zalloua, Pierre A. (2019-07-25)
    Coronary artery disease (CAD) is the commonest cause of death. Here, we report an association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching genome-wide significance, taking the number of ...
  • Multivariate epidemiologic analysis of type 2 diabetes mellitus risks in the Lebanese population 
    Ghassibe-Sabbagh, Michella; Deeb, Mary; Saloum, Angelique K.; Hirbli, Kamal; Ahdab, Rechdi; Zalloua, Pierre A.; Nemr, Rita; Mouzaya, Francis; Chami, Youssef; Akle, Yasmine; Platt, Daniel E. (2016-06-14)
    Background: The burden of diabetes in Lebanon requires well-targeted interventions for screening type 2 diabetes mellitus (T2DM) and prediabetes and prevention of risk factors. Newly recruited 998 Lebanese individuals, ...

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