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Browsing SOM - Scholarly Publications by Author "Kopetz, Scott"

Now showing items 1-11 of 11

Aggressive Combined Modality Therapy for Recurrent Colorectal Cancer Involving the Duodenum and Pancreas

Overman, Micheal; Fogelman, David; Al-Kali, Aref; Crane, Christopher; Evans, Douglas; Abdalla, Eddie; Pisters, Peter; Kopetz, Scott; Eng, Cathy; Wolff, Robert (2015-11-17)

We report 5 cases in which the recurrence of colorectal cancer (CRC) presented as a mass involving the duodenum and pancreas. The treatment approach for such recurrences is not standardized, and in particular, the benefits ...
Association of Computed Tomography Morphologic Criteria With Pathologic Response and Survival in Patients Treated With Bevacizumab for Colorectal Liver Metastases

Shin Chun, Yun; Vauthey, Jean-Nicolas; Boonsirikamcha, Piyaporn; Maru, Dipen; Kopetz, Scott; Palavecino, Martin; Curley, Steven; Abdalla, Eddie; Kaur, Harmeet; Charnsangavej, Chusilp; Loyer, Evelyne (2015-11-17)

Context The standard criteria used to evaluate tumor response, the Response Evaluation Criteria in Solid Tumors (RECIST), were developed to assess tumor shrinkage after cytotoxic chemotherapy and may be limited in assessing ...
Blood Neutrophil-to-Lymphocyte Ratio Predicts Survival in Patients with Colorectal Liver Metastases Treated with Systemic Chemotherapy

Abdalla, Eddie; Kishi, Yoji; Kopetz, Scott; Chun, Yun Shin; Palavecino, Martin; Vauthey, Jean-Nicolas (2015-11-17)

Background Whether neutrophil-to-lymphocyte ratio (NLR) predicts survival of patients with colorectal liver metastases (CLM) treated with systemic chemotherapy remains unclear. Methods Clinicopathologic data were reviewed ...
Extended Preoperative Chemotherapy Does Not Improve Pathologic Response and Increases Postoperative Liver Insufficiency After Hepatic Resection for Colorectal Liver Metastases

Kishi, Yoji; Zorzi, Daria; Contreras, Carlo; Maru, Dipen; Kopetz, Scott; Ribero, Dario; Motta, Manuela; Ravarino, Nicoletta; Risio, Mauro; Curley, Steven; Abdalla, Eddie; Capussotti, Lorenzo; Vauthey, Jean-Nicolas (2015-11-19)

Background The optimal duration, safety, and benefit of preoperative chemotherapy in patients with colorectal liver metastases (CLM) are unclear. We evaluated the association between the duration of preoperative chemotherapy ...
High Survival Rate After Two-Stage Resection of Advanced Colorectal Liver Metastases

Brouquet, Antoine; Abdalla, Eddie; Kopetz, Scott; Garrett, Christopher; Overman, Micheal; Eng, Cathy; Andreou, Andreas; Loyer, Evelyne; Madoff, David; Curley, Steven; Vauthey, Jean-Nicolas (2015-11-19)

Purpose Prolonged survival after two-stage resection (TSR) of advanced colorectal liver metastases (CLM) may be the result of selection of best responders to chemotherapy. The impact of complete resection in this well-selected ...
Is resection of colorectal liver metastases after a second-line chemotherapy regimen justified?

Brouquet, Antoine; Overman, Micheal; Kopetz, Scott; Maru, Dipen; Loyer, Evelyne; Andreou, Andreas; Cooper, Amanda; Curley, Steven; Garrett, Christopher; Abdalla, Eddie; Vauthey, Jean-Nicolas (2017-05-23)

BACKGROUND: Patient outcomes following resection of colorectal liver metastases (CLM) after second-line chemotherapy regimen is unknown. METHODS: From August 1998 to June 2009, data from 1099 patients with CLM were ...
Margin Status Remains an Important Determinant of Survival after Surgical Resection of Colorectal Liver Metastases in the Era of Modern Chemotherapy

Andreou, Andreas; Aloia, Thomas; Brouquet, Antoine; Dickson, Paxton; Zimmitti, Guiseppe; Maru, Dipen; Kopetz, Scott; Loyer, Evelyne; Curley, Steven; Abdalla, Eddie; Vauthey, Jean-Nicolas (2015-11-20)

Objective To determine the impact of surgical margin status on overall survival (OS) of patients undergoing hepatectomy for colorectal liver metastases (CLM) after modern preoperative chemotherapy. Summary Background ...
Preoperative Bevacizumab Does Not Significantly Increase Postoperative Complication Rates in Patients Undergoing Hepatic Surgery for Colorectal Cancer Liver Metastases

Kesmodel, Susan; Ellis, Lee; Lin, E.; Chang, George; Abdalla, Eddie; Kopetz, Scott; Vauthey, Jean-Nicolas; Rodriguez-Bigas, Miguel; Curley, Steven; Feig, Barry (2015-11-17)

Purpose Although bevacizumab (BV) increases survival rates when used with chemotherapy (CTX) in patients who have metastatic colorectal cancer (CRC), an increase in wound complications has been observed in patients who ...
Surgical Strategies for Synchronous Colorectal Liver Metastases in 156 Consecutive Patients

Bouquet, Antoine; Mortenson, Melinda; Vauthey, Jean-Nicolas; Rodriguez-Bigas, Miguel; Overman, Micheal; Chang, George; Kopetz, Scott; Garrett, Christopher; Curley, Steven; Abdalla, Eddie (2015-11-19)

Background An increasing number of patients with synchronous colorectal liver metastases (CLM) are candidates for resection. The optimal treatment sequence in these patients has not been defined. Study Design Data ...
Systemic Chemotherapy and Two-Stage Hepatectomy for Extensive Bilateral Colorectal Liver Metastases

Chun, Yun Shin; Vauthey, Nicolas; Ribero, Dario; Donadon, Matteo; Mullen, John; Eng, Cathy; Madoff, David; Chang, David; Ho, Linus; Kopetz, Scott; Wei, Steven; Curley, Steven; Abdalla, Eddie (2015-11-12)

Background Two-stage hepatectomy has been proposed for patients with bilateral colorectal liver metastases (CLM). The aim of this study was to compare the outcome of patients with CLM treated with preoperative chemotherapy ...
Tumor Thickness at the Tumor-normal Interface: A Novel Pathologic Indicator of Chemotherapy Response in Hepatic Colorectal Metastases

Maru, Dipen; Kopetz, Scott; Boonsirikamcha, Piyaporn; Agarwal, Atin; Chun, Yun Shin; Wang, Huamin; Abdalla, Eddie; Kaur, Harmeet; Charnsangavej, Chusilp; Vauthey, Jean-Nicolas; Loyer, Evelyne (2015-11-19)

Background: Progress in the treatment of hepatic colorectal metastases (HCRM) demands pathologic indicators of therapy response. We observed that a majority of residual tumor cells are seen at the tumor-normal interface ...

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