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Browsing SOM - Scholarly Publications by Author "Kennedy, Christopher"

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Browsing SOM - Scholarly Publications by Author "Kennedy, Christopher"

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  • A maladaptive role for EP4 receptors in podocytes 
    Faour, Wissam; Stitt-Cavanagh, Erin; Takami, Kaede; Carter, Anthony; Vaderhyden, Barbara; Ghan, Youfei; Schendeir, Andre; Breyer, Mathieu; Kennedy, Christopher (2015-10-23)
    Inhibition of p38 mitogen-activated protein kinase and cyclooxygenase-2 reduces albuminuria in models of chronic kidney disease marked by podocyte injury. Previously, we identified a feedback loop in podocytes whereby an ...
  • Mechanical stretch and prostaglandin E2 modulate critical signaling pathways in mouse podocytes 
    Faour, Wissam; Thibodeau, Jean-Francois; Kennedy, Christopher (2016-05-09)
    Elevated glomerular capillary pressure (Pgc) and hyperglycemia contribute to glomerular filtration barrier injury observed in diabetic nephropathy (DN). Previous studies showed that hypertensive conditions alone or in ...
  • PGE2 induces COX-2 expression in podocytes via the EP4 receptor through a PKA-independent mechanism 
    Faour, Wissam; Gomi, Kaede; Kennedy, Christopher (2015-10-23)
    Cyclooxygenase-2 (COX-2)-dependent prostaglandin E2 (PGE2) synthesis correlates with the onset of proteinuria and increased glomerular capillary pressure (Pgc) glomerular disease models. We previously showed that an in ...

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