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Browsing SOM - Scholarly Publications by Author "Faour, Wissam"

Now showing items 1-11 of 11

A maladaptive role for EP4 receptors in podocytes

Faour, Wissam; Stitt-Cavanagh, Erin; Takami, Kaede; Carter, Anthony; Vaderhyden, Barbara; Ghan, Youfei; Schendeir, Andre; Breyer, Mathieu; Kennedy, Christopher (2015-10-23)

Inhibition of p38 mitogen-activated protein kinase and cyclooxygenase-2 reduces albuminuria in models of chronic kidney disease marked by podocyte injury. Previously, we identified a feedback loop in podocytes whereby an ...
Biological and anti-inflammatory evaluation of two thiazole compounds in RAW cell line

Faour, Wissam; Hamade, Eva; Habib, Aida; Hachem, Ali; Hussein, Alaa; Abbas, Malak; Hirz, Taghreed (2016-05-09)

The anti-inflammatory effect of two new thiazoles derivatives CX-32 (N-[4-(4-hydroxy-3-methoxyphenyl)-1,3-thiazol-2-yl]acetamide ) and CX-35 (4-(2-amino-1,3-thiazol-4-yl)-2-methoxyphenol), was investigated in LPS-stimulated ...
Early growth response factor-1 mediates prostaglandin E2-dependent transcriptional suppression of cytokine-induced tumor necrosis factor-α gene expression in human macrophages and rheumatoid arthritis-affected synovial fibroblasts

Faour, Wissam; Alaaeddine, Nada; Mancini, Arturo; He, Qing Wen; Jovanovic, Dragan; Di Battista, John (2015-10-23)

Tumor necrosis factor-α (TNF-α) is a pleiotropic proinflammatory cytokine that modulates a broad range of inflammatory and immunological processes. We have investigated the potential immunomodulatory properties of prostaglandin ...
Influence of standardized patient body habitus on undergraduate student performance in an Objective Structured Clinical Examination

Bahous, Sola Aoun; Faour, Wissam; Asmar, Nadia; Yazbeck-Karam, Vanda; Khairallah, Maya (2015-10-23)

Purpose: Previous studies have shown that the standardized patient's (SP) gender may affect student performance in an Objective Structured Clinical Examination (OSCE). The aim of this study is to investigate the influence ...
Mechanical stretch and prostaglandin E2 modulate critical signaling pathways in mouse podocytes

Faour, Wissam; Thibodeau, Jean-Francois; Kennedy, Christopher (2016-05-09)

Elevated glomerular capillary pressure (Pgc) and hyperglycemia contribute to glomerular filtration barrier injury observed in diabetic nephropathy (DN). Previous studies showed that hypertensive conditions alone or in ...
Nimesulide, a preferential cyclooxygenase 2 inhibitor, suppresses peroxisome proliferator‐activated receptor induction of cyclooxygenase 2 gene expression in human synovial fibroblasts: Evidence for receptor antagonism

Faour, Wissam; Kalajdzic, Tanja; He, Qing Wen; Fahmi, Hassan; Martel-Pelletier, Johanne; Pelletier, Jean-Pierre; Di Battista, John (2016-05-17)

Objective To characterize the inhibitory effects of therapeutic concentrations of the nonsteroidal antiinflammatory drug nimesulide (NIM) on peroxisome proliferator-activated receptor (PPAR)-induced cyclooxygenase 2 (COX-2) ...
PGE2 induces COX-2 expression in podocytes via the EP4 receptor through a PKA-independent mechanism

Faour, Wissam; Gomi, Kaede; Kennedy, Christopher (2015-10-23)

Cyclooxygenase-2 (COX-2)-dependent prostaglandin E2 (PGE2) synthesis correlates with the onset of proteinuria and increased glomerular capillary pressure (Pgc) glomerular disease models. We previously showed that an in ...
Proliferation and differentiation of human adipose-derived mesenchymal stem cells (ASCs) into osteoblastic lineage are passage dependent

Faour, Wissam; Abdalla, Eddie; Di Battista, Jiovanni; Shehaby, Wassim; Kizilay, Ozge; Hamade, Eva; Abou Merhi, Raghida; Mebarek, Saida; Abdallah, Dina; Badran, Bassam; Saad, Fady (2016-05-10)

Objective The effect of in vitro expansion of human adipose-derived stem cells (ASCs) on stem cell properties is controversial. We examined serial subcultivation with expansion on the ability of ASCs to grow and differentiate ...
Prostaglandin E2 regulates the level and stability of cyclooxygenase-2 mRNA through activation of p38 mitogen-activated protein kinase in interleukin-1β-treated human synovial fibroblasts

Faour, Wissam; He, Yulan; He, Qing Wen; De ladurantaye, Manon; Quintero, Maritza; Mancini, Arturo; Di Battista, John (2015-10-23)

The p38 MAPK mediates transcriptional and post-transcriptional control of cyclooxygenase-2 (COX-2) mRNA following interleukin-1(IL-1)/lipopolysaccharide cellular activation. We explored a positive feedback, prostaglandin ...
Prostaglandin E2 stimulates p53 transactivational activity through specific serine 15 phosphorylation in human synovial fibroblasts ROLE IN SUPPRESSION OF c/EBP/NF-κB-MEDIATED MEKK1-INDUCED MMP-1 EXPRESSION

Faour, Wissam; He, Qing Wen; Mancini, Arturo; Jovanovic, Dragan; Antoniou, John; Di Battista, John (2016-05-09)

Cyclooxygenase-2 (COX-2) overexpression has been linked to cell survival, transformation, and hyperproliferation. We examined the regulation of the tumor suppressor gene p53 and p53 target genes by prostaglandin E2 (PGE2) ...
T-cell-derived interleukin-17 regulates the level and stability of cyclooxygenase-2 (COX-2) mRNA through restricted activation of the p38 mitogen-activated protein kinase cascade

Faour, Wissam; Mancini, Arturo; He, Qing Wen; Di Battista, John (2015-10-23)

Although interleukin-17 (IL-17) is the pre-eminent T-cell-derived pro-inflammatory cytokine, its cellular mechanism of action remains poorly understood. We explored novel signaling pathways mediating IL-17 induction of the ...

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