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Browsing SOP - Scholarly Publications by Author "Milane, Aline"

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Browsing SOP - Scholarly Publications by Author "Milane, Aline"

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  • ABCB1 (P-glycoprotein) and blood-brain barrier 
    Milane, Aline; Vautier, S.; Fernandez, C. (2017-12-20)
    ABCB1 (MDR1/P-glycoprotein) is an ATP-dependant transmenbrane protein widely expressed in human organs, protecting them against xenobiotics. ABCB1 is involved in drug pharmacokinetics: at the blood-brain barrier level, due ...
  • Association of coronary artery disease and chronic kidney disease in Lebanese population 
    Milane, Aline; Khazen, Georges; Salloum, Angelique K.; Zalloua, Pierre; Ghassibe-Sabbagh, Michella; Zeineddine, Nabil; Masri, Leila; El Bayeh, Hamid (2016-03-17)
    Background: More evidence is emerging on the strong association between chronic kidney disease (CKD) and cardiovascular disease. We assessed the relationship between coronary artery disease (CAD) and renal dysfunction level ...
  • Association of hypertension with coronary artery disease onset in the Lebanese population 
    Milane, Aline; Abdallah, Jad; Kanbar, Roy; Khazen, Georges; Saad, Aline; Ghassibe-Sabbagh, Michella; Salloum, Angelique K.; Youhanna, Sonia; Saad, Aline; El Bayeh, Hamid; Chammas, Elie; Platt, Daniel E.; Hager, Jorg; Gauguier, Dominique; Zalloua, Pierre (2017-04-11)
    The onset of coronary artery disease (CAD) is influenced by cardiovascular risk factors that often occur in clusters and may build on one another. The objective of this study is to examine the relationship between hypertension ...
  • Brain and plasma riluzole pharmacokinetics 
    Milane, Aline; Tortolano, Lionel; Fernadez, Christine; Bensimon, Gilbert; Meininger, Vincent; Farinotti, Robert (2016-10-04)
    Purpose. Amyotrophic lateral sclerosis is a fatal neurodegenerative disease characterized by the loss of motorneurons. The only drug approved is riluzole. Minocycline is an antibiotic with numerous neuroprotective ...
  • Effectiveness of a Technology-Based Intervention to Teach Evidence-Based Practice: The EBR Tool 
    Long, JoAnn D.; Gannaway, Paula; Ford, Cindy; Doumit, Rita; Zeeni, Nadine; Sukkarieh-Haraty, Ola; Milane, Aline; Byers, Beverly; Harrison, LaNell; Hatch, Daniel; Brown, Justin; Proper, Sharlan; White, Patricia; Song, Huaxin (2016-10-04)
    Background As the world becomes increasingly digital, advances in technology have changed how students access evidence-based information. Research suggests that students overestimate their ability to locate quality online ...
  • Genetic and environmental influences on total plasma homocysteine and its role in coronary artery disease risk 
    Milane, Aline; Platt, Daniel E.; Ghassibe-Sabbagh, Michella; Youhanna, Sonia; Abchee, Antoine B.; Haber, Marc; Badro, Danielle A.; Salloum, Angelique K.; Douayhi, Bouchra; Nemr, Rita; Cazier, Jean-Baptiste; Zalloua, Pierre A. (2016-10-05)
    Background Elevated levels of total plasma homocysteine are a risk factor for atherosclerotic disease. Aims The rationale behind this study is to explore the correlation between degree and site of coronary lesion ...
  • Implementing an interprofessional education programme in Lebanon 
    Farra, Anna; Zeenny, Rony; Nasser, Soumana; Asmar, Nadia; Milane, Aline; Bassil, Maya; Haidar, Mona; Habre, Maha; Zeeni, Nadine; Hoffart, Nancy (2019-10-15)
    Background: The Lebanese American University has a well-functioning inter-professional education (IPE) programme; this is a fundamental pedagogical approach in healthcare education in which students from different professions ...
  • Interactions between antiparkinsonian drugs and ABCB1/P-glycoprotein at the blood–brain barrier in a rat brain endothelial cell model 
    Vautier, Sarah; Milane, Aline; Fernandez, Christine; Buyse, Marion; Chacun, Helene; Farinotti, Robert (2016-10-04)
    Parkinson's disease is a neurodegenerative disorder that requires treatment by dopaminergic agonists, which may be responsible for central side effects. We hypothesized that the efflux transporter ABCB1/P-glycoprotein ...
  • Interactions between riluzole and ABCG2/BCRP transporter 
    Milane, Aline; Vautier, Sarah; Chacun, Helene; Meininger, Vincent; Bensimon, Gilbert; Farinotti, Robert; Fernandez, Christine (2016-10-04)
    Amyotrophic lateral sclerosis (ALS) is a neurodegenerative fatal disease. Drugs used in this disease need to cross the blood–brain barrier (BBB). Only riluzole is approved for ALS treatment. We have investigated riluzole ...
  • Minocycline and riluzole brain disposition 
    Milane, Aline; Fernandez, Christine; Vautier, Sarah; Meininger, Vincent; Farinotti, Robert; Bensimon, Gilbert (2016-10-04)
    Amyotrophic lateral sclerosis is a neurodegenerative fataldisease. The only drug recognized to increase the survivaltime is riluzole(RLZ). In animal models, minocycline (MNC)delayed the onset of the disease and increased ...
  • P-glycoprotein expression and function are increased in an animal model of amyotrophic lateral sclerosis 
    Milane, Aline; Fernandez, Christine; Dupuis, Luc; Buyse, Marion; Loeffler, Jean-Philippe; Farinotti, Robert; Meininger, Vincent; Bensimon, Gilbert (2016-10-04)
    The efflux pumps located at the blood–brain barrier (BBB) prevent drugs entering the brain. As such, efflux pumps are a major obstacle to drug brain distribution. Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative ...
  • Preclinical impact of bevacizumab on brain and tumor distribution of irinotecan and temozolomide 
    Milane, Aline; Goldwirt, Lauriane; Beccaria, Kevin; Carpentier, Alexandre; Idbaih, Ahmed; Schmitt, Charlotte; LEvasseur, Camille; Labussiere, Marianne; Farinotti, Robert; Fernandez, Christine (2016-10-05)
    Glioblastoma (GBM) is the most common primary malignant brain tumour in adults. Prognosis of GBM patients is poor with median overall survival around 15 months. Temozolomide is the chemotherapeutic agent used in the standard ...
  • Prevalence of depression in Parkinson’s disease in a Lebanese tertiary clinic 
    Ghaddar, Alissar; Fawaz, Mohammad; Khazen, Georges; Abdallah, Jad; Milane, Aline (2016-07-19)
    Diagnosis of Parkinson’s disease can be emotionally and psychologically challenging to patients. The aim of this study is to investigate the association between Parkinson’s disease and depression and the impact of the ...
  • Role of two efflux proteins, ABCB1 and ABCG2 in blood-brain barrier transport of bromocriptine in a murine model of MPTP-induced dopaminergic degeneration 
    Milane, Aline; Vautier, Sarah; Fernandez, Christine; Chacun, Helene; Lacomble, Luccette; Farinotti, Robert (2016-10-04)
    Purpose: MPTP-induced dopaminergic degeneration is an experimental model commonly used to explore Parkinson’s disease. Cerebral drug transport by ABC transporters in MPTP models has never been reported. Methods: We have ...
  • Student perceptions towards interprofessional education 
    Zeeni, Nadine; Bassil, Maya; Nasser, Soumana; Milane, Aline; Habre, Maha; Khazen, Georges; Asmar, Nadia; Hasbini-Danawi, Tala; Farra, Anna; Zeeenny, Rony; Hoffart, Nancy (2016-10-05)
    The Lebanese American University Interprofessional Education (LAU IPE) Steps Framework consists of a five-step workshop-based series that is offered throughout the curriculum of health and social care students at an ...

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