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Browsing SOP - Scholarly Publications by Author "Meininger, Vincent"

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Browsing SOP - Scholarly Publications by Author "Meininger, Vincent"

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  • Brain and plasma riluzole pharmacokinetics 
    Milane, Aline; Tortolano, Lionel; Fernadez, Christine; Bensimon, Gilbert; Meininger, Vincent; Farinotti, Robert (2016-10-04)
    Purpose. Amyotrophic lateral sclerosis is a fatal neurodegenerative disease characterized by the loss of motorneurons. The only drug approved is riluzole. Minocycline is an antibiotic with numerous neuroprotective ...
  • Interactions between riluzole and ABCG2/BCRP transporter 
    Milane, Aline; Vautier, Sarah; Chacun, Helene; Meininger, Vincent; Bensimon, Gilbert; Farinotti, Robert; Fernandez, Christine (2016-10-04)
    Amyotrophic lateral sclerosis (ALS) is a neurodegenerative fatal disease. Drugs used in this disease need to cross the blood–brain barrier (BBB). Only riluzole is approved for ALS treatment. We have investigated riluzole ...
  • Minocycline and riluzole brain disposition 
    Milane, Aline; Fernandez, Christine; Vautier, Sarah; Meininger, Vincent; Farinotti, Robert; Bensimon, Gilbert (2016-10-04)
    Amyotrophic lateral sclerosis is a neurodegenerative fataldisease. The only drug recognized to increase the survivaltime is riluzole(RLZ). In animal models, minocycline (MNC)delayed the onset of the disease and increased ...
  • P-glycoprotein expression and function are increased in an animal model of amyotrophic lateral sclerosis 
    Milane, Aline; Fernandez, Christine; Dupuis, Luc; Buyse, Marion; Loeffler, Jean-Philippe; Farinotti, Robert; Meininger, Vincent; Bensimon, Gilbert (2016-10-04)
    The efflux pumps located at the blood–brain barrier (BBB) prevent drugs entering the brain. As such, efflux pumps are a major obstacle to drug brain distribution. Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative ...

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