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Browsing SOP - Scholarly Publications by Issue Date

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Browsing SOP - Scholarly Publications by Issue Date

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  • Protein Isoaspartate Methyltransferase Is a Multicopy Suppressor of Protein Aggregation in Escherichia coli 
    Kern, Renee; Malki, Abderrahim; Abdallah, Jad; Lebart, Jean-Claude; Dubucs, Catherine; Hee Yu, Myeong; Richarme, Gilbert (2016-07-19)
    We used preS2-S′-β-galactosidase, a three-domain fusion protein that aggregates extensively at 43°C in the cytoplasm of Escherichia coli, to search for multicopy suppressors of protein aggregation and inclusion body formation ...
  • YhbO Protects Cells against Multiple Stresses 
    Abdallah, Jad; Caldas, Teresa; Kthiri, Fatoum; Kern, Renee; Richarme, Gilbert (2016-07-19)
    YhbO is a member of the DJ-1/ThiJ/Pfp1 superfamily, which includes chaperones, peptidases, and the Parkinson's disease protein DJ-1. A yhbO-disrupted mutant of Escherichia coli is highly sensitive to oxidative, thermal, ...
  • Prevalence of depression in Parkinson’s disease in a Lebanese tertiary clinic 
    Ghaddar, Alissar; Fawaz, Mohammad; Khazen, Georges; Abdallah, Jad; Milane, Aline (2016-07-19)
    Diagnosis of Parkinson’s disease can be emotionally and psychologically challenging to patients. The aim of this study is to investigate the association between Parkinson’s disease and depression and the impact of the ...
  • Cloning, expression, and purification of the general stress protein YhbO from Escherichia coli 
    Abdallah, Jad; Kern, Renee; Malki, Abderrahim; Eckey, Viola; Richarme, Gilbert (2016-07-19)
    We cloned, expressed, and purified the Escherichia coli yhbO gene product, which is an aminoacid sequence homolog to the Bacillus subtilis general stress protein 18 (the yfkM gene product), the Pyrococcus furiosus intracellular ...
  • The Escherichia coli thioredoxin homolog YbbN/Trxsc is a chaperone and a weak protein oxidoreductase 
    Caldas, Thérèse; Kern, Renee; Malki, Abderrahim; Abdallah, Jad; Richarme, Gilbert (2016-07-19)
    Escherichia coli contains two thioredoxins, Trx1 and Trx2, and a thioredoxin-like protein, YbbN, which presents a strong homology in its N-terminal part with thioredoxin 1 and 2. YbbN, however, does not possess the canonical ...
  • The DJ-1 superfamily member Hsp31 repairs proteins from glycation by methylglyoxal and glyoxal 
    Mihoub, Mouadh; Abdallah, Jad; Gontero, Brigitte; Dairou, Julien; Richarme, Gilberte (2016-07-19)
    Hsp31 belongs to the PfpI/Hsp31/DJ-1 superfamily, and has been reported to display chaperone, peptidase and glutathione-independent glyoxalase activities. Here, we show that Hsp31 repairs glyoxal- and methylglyoxal-glycated ...
  • Peptidase Activity of the Escherichia coli Hsp31 Chaperone 
    Malki, Abderrahim; Caldas, Therese; Abdallah, Jad; Kern, Renee; Eckey, Viola; Kim, So Jung; Cha, Sun-Shin; Mori, Hirotada; Richard, Richarme (2016-07-19)
    Hsp31, the Escherichia coli hcha gene product, is a molecular chaperone whose activity is inhibited by ATP at high temperature. Its crystal structure reveals a putative Cys184, His185, and Asp213 catalytic triad similar ...
  • The thioredoxin homolog YbbN functions as a chaperone rather than as an oxidoreductase 
    Kthiri, Fatoum; Le, Hai-Tuong; Tagourti, Jihen; Kern, Renee; Malki, Abderrahim; Caldas, Teresa; Abdallah, Jad; Landoulsi, Ahmed; Richarme, Gilbert (2016-07-19)
    Escherichia coli contains two thioredoxins, Trx1 and Trx2, and a thioredoxin-like protein, YbbN, which presents a strong homology in its N-terminal part with thioredoxins, and possesses a 20 kDa C-terminal part of unknown ...
  • The DJ-1 superfamily members YhbO and YajL from Escherichia coli repair proteins from glycation by methylglyoxal and glyoxal 
    Abdallah, Jad; Mihoub, Mouadh; Gautier, Valeire; Richarme, Gilbert (2016-07-19)
    YhbO and YajL belong to the PfpI/Hsp31/DJ-1 superfamily. Both proteins are involved in protection against environmental stresses. Here, we show that, like DJ-1 and Hsp31, they repair glyoxal- and methylglyoxal-glycated ...
  • Solubilization of Protein Aggregates by the Acid Stress Chaperones HdeA and HdeB 
    Malki, Abderrahim; Le, Hai-Tuong; Milles, Sigrid; Kern, Renee; Caldas, Teresa; Abdallah, Jad; Richarme, Gilbert (2016-07-19)
    The acid stress chaperones HdeA and HdeB of Escherichia coli prevent the aggregation of periplasmic proteins at acidic pH. We show in this report that they also form mixed aggregates with proteins that have failed to be ...
  • Pharmacist recognition of and adherence to medication-use policies and safety practices 
    Saad, Aline; Sweet, Burgunda; Stumpf, Janice; Gruppen, Larry; Oh, Mary; Stevenson, James (2016-09-23)
    Purpose. Pharmacist recognition of and adherence to medication-use policies and safety practices were assessed. Methods. Simulation testing was used to assess the performance of pharmacists in hypothetical scenarios ...
  • Physicians' attitudes toward clinical pain management and education 
    Nasser, Soumana C.; Saad, Aline Hanna; Nassif, Jeanette G. (2016-09-23)
    Despite promising initiatives to advance the practice of pain management in Middle Eastern countries, their pain care lags behind developed countries. The objectives of this study are to evaluate physicians’ assessment of ...
  • Factors Influencing the Magnitude and Clinical Significance of Drug Interactions Between Azole Antifungals and Select Immunosuppressants 
    Saad, Aline (2016-09-23)
    The magnitude of drug interactions between azole antifungals and immunosuppressants is drug and patient specific and depends on the potency of the azole inhibitor involved, the resulting plasma concentrations of each drug, ...
  • Mapping and assessment of personal and professional development skills in a pharmacy curriculum 
    Ramia, Elsy; Salameh, Pascale; Btaiche, Imad F.; Saad, Aline Hanna (2016-09-23)
    Background Health sciences programs are increasingly expanding their curricula to bridge foundational scientific knowledge with needed skills to practice and patient care. The primary objectives of this study are to 1) ...
  • Amoxicillin/Clavulanic Acid-Induced Thrombocytopenia 
    Mansour, Hanine; Saad, Aline; Azar, Marina; Khoueiry, Paul (2016-09-23)
    Introduction and Objective: Drug-induced thrombocytopenia is a common adverse effect reported in the literature. Typically patients present with a low platelet count with signs and symptoms ranging from bruising to bleeding, ...
  • Hints for success in ASHP’s Clinical Skills Competition 
    Der-Nigoghossian, Caroline A.; Eldebs, Melissa; Karaoui, Lamis R.; Saad, Aline (2016-09-23)
  • Renin–angiotensin-system gene polymorphisms and depression 
    Saab, Yolande B.; Gard, Paul R.; Yeoman, Mark S.; Mfarref, Bechara; El-Moalen, Bechara (2016-09-26)
    Given the abundance of the renin–angiotensin system (RAS) components in the brain, their importance in behavior and cognition, and the data that implicates them in the etiology and treatment of depression, it is possible ...
  • Attitudes of Physicians to Professional Roles of Community Pharmacists in Lebanon 
    Saab, Yolande B.; Hachem, Ayla H. (2016-09-26)
    Background: Pharmacists involved in patient-centred clinical services can potentially reduce overall healthcare costs, morbidity and mortality. However, physicians might be ambivalent about pharmacists' capabilities. Aim: ...
  • Pharmacy education in Lebanon 
    Saab, Yolande B.; Khachan, Victor; Sadik, Farid (2016-09-26)
    Objective Challenges faced by academia are no longer shaped by information accessibility but rather, and perhaps surprisingly so, by availability. A case in point is the lack of information on pharmacy education in ...
  • Buccal Cell DNA Extraction 
    Saab, Yolande B.; Kabbara, Wissam; Chebib, Christiane; Gard, Paul Richard (2016-09-26)
    Simple and cost-effective methods are needed to extract DNA in order to use it in large-scale studies. Blood is an excellent DNA source; however, it is costly and invasive thus an alternative is needed. Several kits and ...

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