Wild-type anthrax lethal toxin (PrAg/LF) demonstrated high potency in inhibiting the MAPK pathway in AML cell lines that rely on this pathway for survival. PrAg/LF is a binary toxin consisting of protective antigen (PrAg), ...

Anthrax lethal toxin is a two-component toxin consisting of protective antigen (PrAg), the cell binding and translocation domain, and lethal factor (LF), the catalytic domain, which cleaves all mitogen-activated ...

Acute myeloid leukemia (AML) is a hematopoietic malignancy characterized by abnormal proliferation of myeloid progenitor cells. Around 15,000 new case of AML are diagnosed each year with a fatality rate of 65%. Conventional ...