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Browsing SoAS - Scholarly Publications by Author "Wu, Haiyan"

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Browsing SoAS - Scholarly Publications by Author "Wu, Haiyan"

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  • Over‐expression of the p110β but not p110α isoform of PI 3‐kinase inhibits motility in breast cancer cells 
    Yip, Shu-Chin; El-Sibai, Mirvat; Hill, Karen M.; Wu, Haiyan; Fu, Zheng; Condeelis, John S.; Backer, Jonathan M. (2015-11-09)
    Phosphoinositide 3-kinase (PI 3-kinase) activity is required for growth factor-induced cytoskeletal regulation and cell migration. We previously found that in MTLn3 rat adenocarcinoma cells, EGF-stimulated induction of ...
  • Regulation of Class IA PI 3-kinases 
    Wu, Haiyan; Shekar, S. Chandra; Flinn, Rory J.; El-Sibai, Mirvat; Jaiswal, Bijay S.; Sen, K. Ilker; Janakiraman, Vasantharajan; Seshagiri, Somasekar; Gerfen, Gary J.; Girvin, Mark E.; Backer, Jonathan M. (2015-11-04)
    We previously proposed a model of Class IA PI3K regulation in which p85 inhibition of p110α requires (i) an inhibitory contact between the p85 nSH2 domain and the p110α helical domain, and (ii) a contact between the p85 ...

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