Abi-Habib, Ralph; Singh, Ravibhushan; Browning, Jeff L.; Wong, Kevin; Williams, Simon A.; Merchant, Rosemina; Denmeade, Samuel R.; Buckley, Thomas J.; Frankel, Arthur E.
(2016-05-11)
Native proaerolysin is a channel-forming bacterial protoxin that binds to cell-surface receptors and then is activated by furin or furin-like proteases. We genetically engineered proaerolysin by replacing the furin-cleavage ...