Browsing SoAS - Scholarly Publications by Author "Leppla, Stephen H."

Now showing items 1-9 of 9

BRAF status and mitogen-activated protein/extracellular signal-regulated kinase kinase 1/2 activity indicate sensitivity of melanoma cells to anthrax lethal toxin

Abi-Habib, Ralph J.; Urieto, Jeffrey O.; Leppla, Stephen H.; Duesbery, Nicholas S.; Frankel, Arthur E. (2015-11-30)

Anthrax lethal toxin, composed of protective antigen and lethal factor, was tested for cytotoxicity to human melanoma cell lines and normal human cells. Eleven of 18 melanoma cell lines were sensitive to anthrax lethal ...
Characterization of urokinase plasminogen activator-activated recombinant anthrax toxin for targeted cancer therapy

Abi-Habib, Ralph J.; Singh, Ravibhushan; Duesbery, Nicholas S.; Liu, Shihui; Bugge, Thomas H.; Leppla, Stephen H. (2018-06-18)

Anthrax lethal toxin (LeTx), secreted by Bacillus anthracis, consists of protective antigen (PrAg) and lethal factor (LF). Following binding to its ubiquitously expressed cell surface receptors tumor endothelium marker 8 ...
Cytotoxicity of Anthrax Lethal Toxin to Human Acute Myeloid Leukemia Cells Is Nonapoptotic and Dependent on Extracellular Signal-Regulated Kinase 1/2 Activity

Abi-Habib, Ralph J.; Kassab, Elias; Timsah, Zahra; Liu, Shihui; Leppla, Stephen H.; Frankel, Arthur; Darwish, Manal (2015-12-01)

In this study, we attempt to target the mitogen-activated protein kinase (MAPK) pathway in acute myeloid leukemia (AML) cells using a recombinant anthrax lethal toxin (LeTx). LeTx consists of protective antigen (PrAg) and ...
Diphtheria toxin-murine granulocyte-macrophage colony-stimulating factor–induced hepatotoxicity is mediated by Kupffer cells

Abi-Habib, Ralph J.; Westcott, Marlena; Cohen, Kimberley; Willingham, Mark; Lui, Shihui; Bugge, Thomas; Leppla, Stephen H.; Frankel, Arthur (2016-05-10)

DT388GMCSF, a fusion toxin composed of the NH2-terminal region of diphtheria toxin (DT) fused to human granulocyte-macrophage colony-stimulating factor (GMCSF) has shown efficacy in the treatment of acute myeloid leukemia. ...
Phospho-MEK1/2 and uPAR Expression Determine Sensitivity of AML Blasts to a Urokinase-Activated Anthrax Lethal Toxin (PrAgU2/LF) 1

Nasser, Selim; Ghanem, Hadi; Abi-Habib, Ralph J.; Bekdash, Amira; Darwish, Manal; Timsah, Zahra; Najjar, Vicky; Ghosn, Marwan; El-Hajj, Hiba; Bazerbachi, Ali; Liu, Shihui; Leppla, Stephen H.; Frankel, Arthur E.; Kassab, Elias (2017-02-02)

In this study, we attempt to target both the urokinase plasminogen activator and the mitogen-activated protein kinase pathway in acute myeloid leukemia (AML) cell lines and primary AML blasts using PrAgU2/LF, a urokinase-activated ...
Systemic anthrax lethal toxin therapy produces regressions of subcutaneous human melanoma tumors in athymic nude mice

Abi-Habib, Ralph J.; Singh, Ravibhushan; Leppla, Stephen H.; Greene, John J.; Ding, Yan; Berghuis, Bree; Duesbery, Nicholas S.; Frankel, Arthur E. (2015-11-30)

Purpose: Anthrax Lethal Toxin (LeTx), composed of protective antigen and lethal factor, catalytically cleaves mitogen-activated protein kinase (MAPK) kinases and inhibits the MAPK signaling pathways. The majority of ...
Targeting the MAP kinase pathway in astrocytoma cells using a recombinant anthrax lethal toxin as a way to inhibit cell motility and invasion

Al-Dimassi, Saleh; Salloum, Gilbert; Saykali, Bechara; Khoury, Oula; Liu, Shihui; Leppla, Stephen H.; Abi-Habib, Ralph; El-Sibai, Mirvat (2016-12-14)

Malignant astrocytomas are highly invasive into adjacent and distant regions of the normal brain. Understanding and targeting cancer cell invasion is an important therapeutic approach. Cell invasion is a complex process ...
A urokinase-activated recombinant anthrax toxin is selectively cytotoxic to many human tumor cell types

Abi-Habib, Ralph J.; Singh, Ravibhushan; Liu, Shihui; Bugge, Thomas; Leppla, Stephen H.; Frankel, Arthur (2015-12-01)

Urokinase plasminogen activator (uPA) is a tumor-specific protease highly expressed in several types of solid tumors and rarely present on normal cells under physiologic conditions. Due to its high expression on metastatic ...
A urokinase-activated recombinant diphtheria toxin targeting the granulocyte-macrophage colony-stimulating factor receptor is selectively cytotoxic to human acute myeloid leukemia blasts

Abi-Habib, Ralph J.; Lui, Shihui; Bugge, Thomas; Leppla, Stephen H.; Frankel, Arthur (2015-11-30)

Novel agents to treat acute myeloid leukemia (AML) are needed with increased efficacy and specificity. We have synthesized a dual-specificity fusion toxin DTU2GMCSF composed of the catalytic and translocation domains of ...

Now showing items 1-9 of 9

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