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Browsing SoAS - Scholarly Publications by Author "Khazen, Georges"

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Browsing SoAS - Scholarly Publications by Author "Khazen, Georges"

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  • ALOX5AP gene variants show differential association with coronary artery disease in different populations 
    Alwan, Ahmad; Youhanna, Sonia C.; Platt, Daniel E.; El-Sibai, Mirvat; Yerezian, Joumana S.; Deeb, Mary E.; Khazen, Georges; Saade, Stephanie; Zreik, Tony G.; El Bayeh, Hamid; Maalouf, Assaad; Zalloua, Pierre A.; Abchee, Antoine (2015-12-17)
    Coronary artery disease (CAD) is a complex disease with various components, genetic as well as environmental. Previous reports correlating ALOX5AP gene variants and CAD showed conflicting results depending on the population ...
  • Anxiety as a moderator of the relationship between body image and restrained eating 
    Doumit, Rita; Zeeni, Nadine; Sanchez-Ruiz, Maria-José; Khazen, Georges (2016-03-17)
    Purpose To examine three indicators of psychopathology (stress, anxiety, and depression) as potential moderators of the relationship between body image dissatisfaction (BID) and restrained, emotional, and external eating, ...
  • Association of coronary artery disease and chronic kidney disease in Lebanese population 
    Milane, Aline; Khazen, Georges; Salloum, Angelique K.; Zalloua, Pierre; Ghassibe-Sabbagh, Michella; Zeineddine, Nabil; Masri, Leila; El Bayeh, Hamid (2016-03-17)
    Background: More evidence is emerging on the strong association between chronic kidney disease (CKD) and cardiovascular disease. We assessed the relationship between coronary artery disease (CAD) and renal dysfunction level ...
  • Association of hypertension with coronary artery disease onset in the Lebanese population 
    Milane, Aline; Abdallah, Jad; Kanbar, Roy; Khazen, Georges; Saad, Aline; Ghassibe-Sabbagh, Michella; Salloum, Angelique K.; Youhanna, Sonia; Saad, Aline; El Bayeh, Hamid; Chammas, Elie; Platt, Daniel E.; Hager, Jorg; Gauguier, Dominique; Zalloua, Pierre (2017-04-11)
    The onset of coronary artery disease (CAD) is influenced by cardiovascular risk factors that often occur in clusters and may build on one another. The objective of this study is to examine the relationship between hypertension ...
  • Cataract surgery outcomes at a UK independent sector treatment centre 
    Khazen, Georges; Syed, Zeba A.; Moayedi, Javad; Tashter, Jacob; Anthony, Teresa; Celiker, Celadet; Melki, Samir A. (2016-03-17)
    Background/Aims The goal of this study was to review cataract surgery outcomes at three independent surgery treatment centres established by the UK Specialist Hospitals (UKSH) and to compare these outcomes with recognised ...
  • Channelpedia 
    Khazen, Georges; Ranjan, Rajnish; Gambazzi, Luca; Ramaswamy, Srikanth; Markram, Henry; Hill, Sean L.; Schürmann, Felix (2016-03-17)
    Ion channels are membrane proteins that selectively conduct ions across the cell membrane. The flux of ions through ion channels drives electrical and biochemical processes in cells and plays a critical role in shaping ...
  • Circulating lipid levels and risk of coronary artery disease in a large group of patients undergoing coronary angiography 
    Deeb, Mary E.; Khazen, Georges; Zalloua, Pierre A.; Platt, Daniel E.; Ghassibe-Sabbagh, Michella; Cazier, Jean-Baptiste; Kamatani, Yoichiro; Salloum, Angelique K.; Hager, Jo¨rg; Youhanna, Sonia (2016-11-23)
    A main underlying pathology of coronary artery disease is the deposition of cholesterol in the arteries supplying blood to the heart that leads to stenosis and myocardial infarction. We tested if dyslipidemia is a risk ...
  • Combinatorial Expression Rules of Ion Channel Genes in Juvenile Rat (Rattus norvegicus) Neocortical Neurons 
    Khazen, Georges; Hill, Sean L.; Schurmann, Felix; Markram, Henry (2016-03-17)
    The electrical diversity of neurons arises from the expression of different combinations of ion channels. The gene expression rules governing these combinations are not known. We examined the expression of twenty-six ion ...
  • Comparison of outcomes between laparoscopic Roux-en-Y gastric bypass and sleeve gastrectomy in a lebanese bariatric surgical practice 
    Khazen, Georges; Safadi, Bassem Y.; Aridi, Hanaa Dakour (2018-04-26)
    Purpose Long-term studies on the outcomes of bariatric surgery are still limited in the Middle East. The aim of this study is to compare the outcomes of laparoscopic Roux-en-Y gastric bypass (LRYGB) and sleeve gastrectomy ...
  • Distribution of Killer Cell Immunoglobulin–like Receptor (KIR) Genotypes in Patients with Familial Mediterranean Fever 
    Khazen, Georges; Khalaf, Roy A.; Mahfouz, Rami A.R.; Sabbagh, Amira S.; Shamseddine, Wael; Bazarbachi, Ali (2016-03-17)
    Genotypic profiles of the natural killer cell immunoglobulin–like receptors (KIR) have been reported to vary among different ethnic groups and variable clinical entities. This study represents the first report on its ...
  • General developmental health in the VPA-rat model of autism 
    Khazen, Georges; Favre, Monica R.; Barakat, Tania R.; LaMendola, Deborah; Markram, Henry; Markram, Kamila (2016-03-17)
    Autism is a neurodevelopmental condition diagnosed by impaired social interaction, abnormal communication and, stereotyped behaviors. While post-mortem and imaging studies have provided good insights into the neurobiological ...
  • Genome Analysis of Streptococcus pyogenes Associated with Pharyngitis and Skin Infections 
    Khazen, Georges; Tokajian, Sima; Ibrahim, Joe; Eisen, Jonathan A.; Jospin, Guillaume; Coil, David A. (2017-04-11)
    Streptococcus pyogenes is a very important human pathogen, commonly associated with skin or throat infections but can also cause life-threatening situations including sepsis, streptococcal toxic shock syndrome, and necrotizing ...
  • Genome-Wide Association Study in a Lebanese Cohort Confirms PHACTR1 as a Major Determinant of Coronary Artery Stenosis 
    Hager, Jorg; Kamatani, Yoichiro; Cazier, Jean-Baptiste; Youhanna, Sonia; Ghassibe-Sabbagh, Michella; Platt, Daniel E.; Abchee, Antoine B.; Romanos, Jihane; Khazen, Georges; Othman, Raed; Badro, Danielle A.; Haber, Marc; Salloum, Angelique K.; Zalloua, Pierre A. (2016-03-17)
    The manifestation of coronary artery disease (CAD) follows a well-choreographed series of events that includes damage of arterial endothelial cells and deposition of lipids in the sub-endothelial layers. Genome-wide ...
  • Impact of inflammation, gene variants, and cigarette smoking on coronary artery disease risk 
    Merhi, Mahmoud; Demirdjian, Sally; Hariri, Essa; Sabbah, Nada; Youhanna, Sonia; Ghassibe-Sabbagh, Michella; Naoum, Joseph; Haber, Marc; Kanbar, Roy; Zalloua, Pierre; Khazen, Georges (2016-03-17)
    Background The role of inflammation in coronary artery disease (CAD) pathogenesis is well recognized. Moreover, smoking inhalation increases the activity of inflammatory mediators through an increase in leukotriene synthesis ...
  • Investigating vulnerability for developing eating disorders in a multi-confessional lebanese sample 
    Khazen, Georges; Doumit, Rita; Katsounari, Ioanna; Kazandjian, Chant; Long, Joann D.; Zeeni, Nadine (2018-04-26)
    Session presented on Friday, July 24, 2015: Purpose: The present study aimed to examine the vulnerability to eating disorders (ED) among 949 Lebanese female young adults as well as its association with stress, anxiety, ...
  • Investigating vulnerability for developing eating disorders in a multi-confessional population 
    Doumit, Rita; Khazen, Georges; Katsounari, Ioanna; Kazandjian, Chant; Long, JoAnn; Zeeni, Nadine (2016-03-17)
    The present study aimed to examine the vulnerability to eating disorders (ED) among 949 Lebanese female young adults as well as its association with stress, anxiety, depression, body image dissatisfaction (BID), dysfunctional ...
  • Mapping post-glacial expansions 
    Khazen, Georges; Zalloua, Pierre A.; Platt, Daniel E.; Dagher- Kharrat, Magda Bou; Douaihy, Bouchra; Bonab, Maziar Ashrafian; Salloum, Angelique; Mouzaya, Francis; Luiselli, Donata; Tyler-Smith, Chris; Renfrew, Colin; Matisoo-Smith, Elizabeth (2017-04-25)
    Archaeological, palaeontological and geological evidence shows that post-glacial warming released human populations from their various climate-bound refugia. Yet specific connections between these refugia and the timing ...
  • MAX-Sense 
    Khazen, Georges; Riachi, Imad; Mouawad, Mounir; Abou-Naccoul, Nada; Artail, Hassan (IEEE Computer Society, 2017-05-10)
    In this paper we are proposing a new distributed system architecture to address the problem of very large scale sensor network monitoring. By dynamically aggregating and processing data from sensor networks, databases and ...
  • Natural Killer Cell Immunoglobulin-like Receptors (KIR) Genotypes in two Arab Populations 
    Khazen, Georges; Rayes, Roni; Bazarbachi, Ali; Sabbagh, Amira; Zaatari, Ghazi; Mahfouz, Rami (2016-03-17)
    Genotypic profiles of the Natural killer cell Immunoglobulin-like Receptors (KIR) have been reported to vary among different ethnic groups and this study represents a comparative report on its distribution between two ...
  • Plasma and urine metabolomic analyses in aortic valve stenosis reveal shared and biofluid-specific changes in metabolite levels 
    Al Hageh, Cynthia; Rahy, Ryan; Khazen, Georges; Brial, Francois; Khnayzer, Rony S.; Gauguier, Dominique; Zalloua, Pierre A. (2023-01-12)
    Aortic valve stenosis (AVS) is a prevalent condition among the elderly population that eventually requires aortic valve replacement. The lack of reliable biomarkers for AVS poses a challenge for its early diagnosis and the ...

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