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Browsing SoAS - Scholarly Publications by Author "Ghassibe-Sabbagh, Michella"

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Browsing SoAS - Scholarly Publications by Author "Ghassibe-Sabbagh, Michella"

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  • Association of coronary artery disease and chronic kidney disease in Lebanese population 
    Milane, Aline; Khazen, Georges; Salloum, Angelique K.; Zalloua, Pierre; Ghassibe-Sabbagh, Michella; Zeineddine, Nabil; Masri, Leila; El Bayeh, Hamid (2016-03-17)
    Background: More evidence is emerging on the strong association between chronic kidney disease (CKD) and cardiovascular disease. We assessed the relationship between coronary artery disease (CAD) and renal dysfunction level ...
  • Association of hypertension with coronary artery disease onset in the Lebanese population 
    Milane, Aline; Abdallah, Jad; Kanbar, Roy; Khazen, Georges; Saad, Aline; Ghassibe-Sabbagh, Michella; Salloum, Angelique K.; Youhanna, Sonia; Saad, Aline; El Bayeh, Hamid; Chammas, Elie; Platt, Daniel E.; Hager, Jorg; Gauguier, Dominique; Zalloua, Pierre (2017-04-11)
    The onset of coronary artery disease (CAD) is influenced by cardiovascular risk factors that often occur in clusters and may build on one another. The objective of this study is to examine the relationship between hypertension ...
  • Circulating lipid levels and risk of coronary artery disease in a large group of patients undergoing coronary angiography 
    Deeb, Mary E.; Khazen, Georges; Zalloua, Pierre A.; Platt, Daniel E.; Ghassibe-Sabbagh, Michella; Cazier, Jean-Baptiste; Kamatani, Yoichiro; Salloum, Angelique K.; Hager, Jo¨rg; Youhanna, Sonia (2016-11-23)
    A main underlying pathology of coronary artery disease is the deposition of cholesterol in the arteries supplying blood to the heart that leads to stenosis and myocardial infarction. We tested if dyslipidemia is a risk ...
  • Genome-Wide Association Study in a Lebanese Cohort Confirms PHACTR1 as a Major Determinant of Coronary Artery Stenosis 
    Hager, Jorg; Kamatani, Yoichiro; Cazier, Jean-Baptiste; Youhanna, Sonia; Ghassibe-Sabbagh, Michella; Platt, Daniel E.; Abchee, Antoine B.; Romanos, Jihane; Khazen, Georges; Othman, Raed; Badro, Danielle A.; Haber, Marc; Salloum, Angelique K.; Zalloua, Pierre A. (2016-03-17)
    The manifestation of coronary artery disease (CAD) follows a well-choreographed series of events that includes damage of arterial endothelial cells and deposition of lipids in the sub-endothelial layers. Genome-wide ...
  • Impact of inflammation, gene variants, and cigarette smoking on coronary artery disease risk 
    Merhi, Mahmoud; Demirdjian, Sally; Hariri, Essa; Sabbah, Nada; Youhanna, Sonia; Ghassibe-Sabbagh, Michella; Naoum, Joseph; Haber, Marc; Kanbar, Roy; Zalloua, Pierre; Khazen, Georges (2016-03-17)
    Background The role of inflammation in coronary artery disease (CAD) pathogenesis is well recognized. Moreover, smoking inhalation increases the activity of inflammatory mediators through an increase in leukotriene synthesis ...
  • Large scale association analysis identifies three susceptibility loci for coronary artery disease 
    El-Khazen, Georges; Zalloua, Pierre A.; Saade, Stephanie; Cazier, Jean-Baptiste; Ghassibe-Sabbagh, Michella; Youhanna, Sonia; Badro, Danielle A.; Kamatani, Yoichiro (2016-03-17)
    Genome wide association studies (GWAS) and their replications that have associated DNA variants with myocardial infarction (MI) and/or coronary artery disease (CAD) are predominantly based on populations of European or ...
  • Multivariate epidemiologic analysis of type 2 diabetes mellitus risks in the Lebanese population 
    Ghassibe-Sabbagh, Michella; Deeb, Mary; Saloum, Angelique K.; Hirbli, Kamal; Ahdab, Rechdi; Zalloua, Pierre A.; Nemr, Rita; Mouzaya, Francis; Chami, Youssef; Akle, Yasmine; Platt, Daniel E. (2016-06-14)
    Background: The burden of diabetes in Lebanon requires well-targeted interventions for screening type 2 diabetes mellitus (T2DM) and prediabetes and prevention of risk factors. Newly recruited 998 Lebanese individuals, ...
  • Y-Chromosome and mtDNA Genetics Reveal Significant Contrasts in Affinities of Modern Middle Eastern Populations with European and African Populations 
    Khazen, Georges; Zalloua, Pierre A.; Badro, Danielle A.; Douaihy, Bouchra; Haber, Marc; Youhanna, Sonia C.; Salloum, Angélique; Ghassibe-Sabbagh, Michella; Johnsrud, Brian (2016-03-17)
    The Middle East was a funnel of human expansion out of Africa, a staging area for the Neolithic Agricultural Revolution, and the home to some of the earliest world empires. Post LGM expansions into the region and subsequent ...

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