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Browsing SoAS - Scholarly Publications by Author "Flinn, Rory J."

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Browsing SoAS - Scholarly Publications by Author "Flinn, Rory J."

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  • Cdc42 is required for EGF-stimulated protrusion and motility in MTLn3 carcinoma cells 
    El-Sibai, Mirvat; Nalbant, Peri; Pang, Huan; Flinn, Rory J.; Sarmiento, Corina; Macaluso, Frank; Cammer, Michael; Condeelis, John S.; Hahn, Klaus M.; Backer, Jonathan M. (2015-11-09)
    Cdc42 plays a central role in regulating the actin cytoskeleton and maintaining cell polarity. Here, we show that Cdc42 is crucial for epidermal growth factor (EGF)- stimulated protrusion in MTLn3 carcinoma cells. ...
  • Regulation of Class IA PI 3-kinases 
    Wu, Haiyan; Shekar, S. Chandra; Flinn, Rory J.; El-Sibai, Mirvat; Jaiswal, Bijay S.; Sen, K. Ilker; Janakiraman, Vasantharajan; Seshagiri, Somasekar; Gerfen, Gary J.; Girvin, Mark E.; Backer, Jonathan M. (2015-11-04)
    We previously proposed a model of Class IA PI3K regulation in which p85 inhibition of p110α requires (i) an inhibitory contact between the p85 nSH2 domain and the p110α helical domain, and (ii) a contact between the p85 ...

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