Browsing SoAS - Scholarly Publications by Author "Coppola, Giovanni"

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Epigenetics of Alzheimer’s disease and frontotemporal dementia

Sleiman, Sama; Veerappan, Chendhore S.; Coppola, Giovanni (2017-09-05)

This article will review the recent advances in the understanding of the role of epigenetic modifications and the promise of future epigenetic therapy in neurodegenerative dementias, including Alzheimer’s disease and ...
Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease

Sleiman, Sama F.; Mashishi, Lata; Coppola, Giovanni; Thompson, Leslie M.; Ratan, Rajiv R.; Starkov, Anatoly; Antonyak, Marc A. (2017-09-06)

Caused by a polyglutamine expansion in the huntingtin protein, Huntington's disease leads to striatal degeneration via the transcriptional dysregulation of a number of genes, including those involved in mitochondrial ...
Mithramycin is a gene-selective Sp1 inhibitor that identifies a biological intersection between cancer and neurodegeneration

Sleiman, Sama F.; Langley, Brett C.; Berlin, Jill; Xia, Li; Payappilly, Jimmy B.; Kharel, Madan K.; Guo, Hengchang; Thonpson, Leslie Michels; Mahishi, Lata; Ahuja, Preeti; Maclellan, W. Robb; Geschwind, Daniel H.; Coppola, Giovanni; Rohr, Jurgen; Ratan, Rajiv R. (2017-10-12)

Oncogenic transformation of postmitotic neurons triggers cell death, but the identity of genes critical for degeneration remain unclear. The antitumor antibiotic mithramycin prolongs survival of mouse models of Huntington's ...

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