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LAUR Repository

School of Pharmacy: Recent submissions

  • Pediatric Short Bowel Syndrome 
    Btaiche, Imad; Spencer, Ariel; Neega, Andreea; West, Brady; Safran, Jared; Brown, Pamela; Kuzma-O'Reilly, Barbara; Teitelbaum, Daniel H. (2016-10-05)
    Objective: To determine predictors of survival and of weaning off parenteral nutrition (PN) in pediatric short bowel syndrome (SBS) patients. Summary Background Data: Pediatric SBS carries extensive morbidity and high ...
  • Genetic and environmental influences on total plasma homocysteine and its role in coronary artery disease risk 
    Milane, Aline; Platt, Daniel E.; Ghassibe-Sabbagh, Michella; Youhanna, Sonia; Abchee, Antoine B.; Haber, Marc; Badro, Danielle A.; Salloum, Angelique K.; Douayhi, Bouchra; Nemr, Rita; Cazier, Jean-Baptiste; Zalloua, Pierre A. (2016-10-05)
    Background Elevated levels of total plasma homocysteine are a risk factor for atherosclerotic disease. Aims The rationale behind this study is to explore the correlation between degree and site of coronary lesion ...
  • Preclinical impact of bevacizumab on brain and tumor distribution of irinotecan and temozolomide 
    Milane, Aline; Goldwirt, Lauriane; Beccaria, Kevin; Carpentier, Alexandre; Idbaih, Ahmed; Schmitt, Charlotte; LEvasseur, Camille; Labussiere, Marianne; Farinotti, Robert; Fernandez, Christine (2016-10-05)
    Glioblastoma (GBM) is the most common primary malignant brain tumour in adults. Prognosis of GBM patients is poor with median overall survival around 15 months. Temozolomide is the chemotherapeutic agent used in the standard ...
  • Student perceptions towards interprofessional education 
    Zeeni, Nadine; Bassil, Maya; Nasser, Soumana; Milane, Aline; Habre, Maha; Khazen, Georges; Asmar, Nadia; Hasbini-Danawi, Tala; Farra, Anna; Zeeenny, Rony; Hoffart, Nancy (2016-10-05)
    The Lebanese American University Interprofessional Education (LAU IPE) Steps Framework consists of a five-step workshop-based series that is offered throughout the curriculum of health and social care students at an ...
  • Effectiveness of a Technology-Based Intervention to Teach Evidence-Based Practice: The EBR Tool 
    Long, JoAnn D.; Gannaway, Paula; Ford, Cindy; Doumit, Rita; Zeeni, Nadine; Sukkarieh-Haraty, Ola; Milane, Aline; Byers, Beverly; Harrison, LaNell; Hatch, Daniel; Brown, Justin; Proper, Sharlan; White, Patricia; Song, Huaxin (2016-10-04)
    Background As the world becomes increasingly digital, advances in technology have changed how students access evidence-based information. Research suggests that students overestimate their ability to locate quality online ...
  • Role of two efflux proteins, ABCB1 and ABCG2 in blood-brain barrier transport of bromocriptine in a murine model of MPTP-induced dopaminergic degeneration 
    Milane, Aline; Vautier, Sarah; Fernandez, Christine; Chacun, Helene; Lacomble, Luccette; Farinotti, Robert (2016-10-04)
    Purpose: MPTP-induced dopaminergic degeneration is an experimental model commonly used to explore Parkinson’s disease. Cerebral drug transport by ABC transporters in MPTP models has never been reported. Methods: We have ...
  • Interactions between antiparkinsonian drugs and ABCB1/P-glycoprotein at the blood–brain barrier in a rat brain endothelial cell model 
    Vautier, Sarah; Milane, Aline; Fernandez, Christine; Buyse, Marion; Chacun, Helene; Farinotti, Robert (2016-10-04)
    Parkinson's disease is a neurodegenerative disorder that requires treatment by dopaminergic agonists, which may be responsible for central side effects. We hypothesized that the efflux transporter ABCB1/P-glycoprotein ...
  • Interactions between riluzole and ABCG2/BCRP transporter 
    Milane, Aline; Vautier, Sarah; Chacun, Helene; Meininger, Vincent; Bensimon, Gilbert; Farinotti, Robert; Fernandez, Christine (2016-10-04)
    Amyotrophic lateral sclerosis (ALS) is a neurodegenerative fatal disease. Drugs used in this disease need to cross the blood–brain barrier (BBB). Only riluzole is approved for ALS treatment. We have investigated riluzole ...
  • P-glycoprotein expression and function are increased in an animal model of amyotrophic lateral sclerosis 
    Milane, Aline; Fernandez, Christine; Dupuis, Luc; Buyse, Marion; Loeffler, Jean-Philippe; Farinotti, Robert; Meininger, Vincent; Bensimon, Gilbert (2016-10-04)
    The efflux pumps located at the blood–brain barrier (BBB) prevent drugs entering the brain. As such, efflux pumps are a major obstacle to drug brain distribution. Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative ...
  • Brain and plasma riluzole pharmacokinetics 
    Milane, Aline; Tortolano, Lionel; Fernadez, Christine; Bensimon, Gilbert; Meininger, Vincent; Farinotti, Robert (2016-10-04)
    Purpose. Amyotrophic lateral sclerosis is a fatal neurodegenerative disease characterized by the loss of motorneurons. The only drug approved is riluzole. Minocycline is an antibiotic with numerous neuroprotective ...
  • Minocycline and riluzole brain disposition 
    Milane, Aline; Fernandez, Christine; Vautier, Sarah; Meininger, Vincent; Farinotti, Robert; Bensimon, Gilbert (2016-10-04)
    Amyotrophic lateral sclerosis is a neurodegenerative fataldisease. The only drug recognized to increase the survivaltime is riluzole(RLZ). In animal models, minocycline (MNC)delayed the onset of the disease and increased ...
  • Olodaterol for the treatment of chronic obstructive pulmonary disease 
    Ramadan, Wijdan H.; Kabbara, Wissam K.; Abilmona, Rosa M. (2016-10-03)
    Purpose. Published data on the pharmacology, pharmacokinetics, efficacy, and safety of the once-daily, long-acting β2-agonist (LABA) olodaterol are reviewed. Summary. Olodaterol (Striverdi Respimat, Boehringer Ingelheim), ...
  • Acute and fatal isoniazid-induced hepatotoxicity 
    Kabbara, Wissam K.; Sarkis, Aline T.; Saroufim, Paola G. (2016-10-03)
    This paper describes a case of an acute and fatal isoniazid-induced hepatotoxicity and provides a review of the literature. A 65-year-old female diagnosed with latent Mycobacterium tuberculosis infection was receiving oral ...
  • Simplicity, safety, and acceptability of insulin pen use versus the conventional vial/syringe device in patients with type 1 and type 2 diabetes mellitus in Lebanon 
    Ramadan, Wijdan H.; Khreis, Noura A.; Kabbara, Wissam K. (2016-10-03)
    Background The aim of the study was to evaluate the simplicity, safety, patients’ preference, and convenience of the administration of insulin using the pen device versus the conventional vial/syringe in patients with ...
  • Sitagliptin/Simvastatin 
    Ramadan, Wijdan H.; Kabbara, Wissam K. (2016-10-03)
    Background The purpose of this study was to review the current literature and information on the combination product Juvisync™ (sitagliptin + simvastatin), which was approved by the US Food and Drug Administration in ...
  • Nitrofurantoin-induced pulmonary toxicity 
    Kabbara, Wissam K.; Kordahi, Melissa C. (2016-10-03)
    This paper describes a case of lung injury attributed to the use of Nitrofurantoin and a review of the relevant literature. An 88-year-old woman was admitted to the floor for the evaluation of recent symptoms of dyspnea, ...
  • Evaluation of the appropriateness of imipenem/cilastatin prescription and dosing in a tertiary care hospital 
    Kabbara, Wissam K.; Nawas, George T.; Ramadan, Wijdan H. (2016-10-03)
    Background Imipenem/cilastatin is an antibacterial agent of the carbapenem class of β-lactams that is known to have an extremely wide spectrum of activity against Gram-positive, Gram-negative, aerobic, anaerobic, and ...
  • Evaluation of the appropriate use of commonly prescribed fluoroquinolones and the risk of dysglycemia 
    Kabbara, Wissam K.; Ramadan, Wijdan H.; Rahbany, Peggy; Al-Natour, Souhaila (2016-10-03)
    Background: Fluoroquinolones are among the most widely prescribed antibiotics. However, concerns about increasing resistant microorganisms and the risk of dysglycemia associated with the use of these agents have ...
  • Emtricitabine/rilpivirine/tenofovir disoproxil fumarate for the treatment of HIV-1 infection in adults 
    Kabbara, Wissam K.; Ramadan, Wijdan H. (2016-10-03)
    This paper reviews the current literature and information on the combination drug Complera™ (rilpivirine/emtricitabine/tenofovir disoproxil fumarate) that was approved by the Food and Drug Administration (FDA) in August ...
  • Diabetic foot infection caused by Raoultella ornithinolytica 
    Kabbara, Wissam K.; Zgheib, Yara R. (2016-10-03)
    Purpose. The case of a diabetic foot infection caused by Raoultella ornithinolytica is reported. Summary. A 68-year-old Caucasian man arrived at the hospital with a fever (38.5 °C) and a foul-smelling pressure ulcer on his ...

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