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Gilbert and Rose-Marie Chagoury School of Medicine: Recent submissions

  • Lebanon during the catastrophe 
    Fadlallah, Najat; Maamari, Julian; Hani, Abeer (2021)
    After several chaotic cycles of resuscitation attempts, the twenty-something-year-old woman was pronounced dead. This was less than half an hour after a massive blast shook the heart of Beirut, Lebanon on the eve of August ...
  • Differential changes in cyclic adenosine 3′-5′ monophosphate (cAMP) effectors and major Ca2+ handling proteins during diabetic cardiomyopathy 
    Chaoul, Victoria; Hanna, Rita; Hachem, Pia; El Hayek, Magali Samia; Nour-Eldine, Wared; Abou-Khalil, Pamela; Abi-Ramia, Elias; Vandecasteele, Grégoire; Abi-Gerges, Aniella (2023-03-27)
    Diabetic cardiomyopathy (DCM) is associated with differential and time-specific regulation of β-adrenergic receptors and cardiac cyclic nucleotide phosphodiesterases with consequences for total cyclic adenosine 3′-5′ ...
  • Nicotine induces resilience to chronic social defeat stress in a mouse model of water pipe tobacco exposure by activating BDNF signaling 
    Khalifeh, Mohamad; Hobeika, Rouba; El Hayek, Lauretta; Saad, Joelle; Eid, Fadi; El-Khoury, Reine; Ghayad, Litsa-Maria; Jabre, Vanessa; Nasrallah, Patrick; Barmo, Nour; Stephan, Joseph S.; Khnayzer, Rony; Christian, Khalil; Sleiman, Sama F. (2023-01-12)
    The purpose of this study was to investigate how nicotine in the context of water pipe tobacco smoking (WTS) affects depression and anxiety-like behaviors associated with chronic social defeat stress (CSDS). Male C57BL/6 ...
  • Knowledge about and attitudes toward medical informed consent: a Lebanese population survey 
    Deeb, Mary; Alameddine, Dana; Abi Radi Abou Jaoudeh, Rasha; Laoun, Widian; Maamari, Julian; Honeini, Rawan; Khouri, Alain; Abou-Mrad, Fadi; Elia, Nassib; Abi-Gerges, Aniella (2023-01-11)
    As Medicine shifts from a paternalistic practice to a patient-centered approach, the concept of medical informed consent (IC) has evolved to safeguard patient autonomy. However, its current implementation still presents ...
  • Acute cytotoxicity, genotoxicity, and apoptosis induced by petroleum VOC emissions in A549 cell line 
    Sayyed, Katia; Nour-Eldine, Wared; Rufka, Anthony; Mehanna, Stephanie; Khnayzer, Rony S.; Abi-Gerges, Aniella; Khalil, Christian (2023-01-09)
    Gasoline is an essential petroleum-derived product powering the automotive economy worldwide. This research focused on the Volatile Organic Component (VOC) cocktail resulting from gasoline evaporation. Petroleum fugitive ...
  • Gasoline fume inhalation induces apoptosis, inflammation, and favors Th2 polarization in C57BL/6 mice 
    Nour-Eldine, Wared; Sayyed, Katia; Harhous, Zeina; Dagher-Hamalian, Carole; Mehanna, Stephanie; Achkouti, Donna; ElKazzaz, Hanan; Khnayzer, Rony S.; Kobeissy, Firas; Khalil, Christian; Abi-Gerges, Aniella (2023-01-09)
    Gasoline exposure has been widely reported in the literature as being toxic to human health. However, the exact underlying molecular mechanisms triggered by its inhalation have not been thoroughly investigated. We herein ...
  • Role of neoadjuvant treatment in clinical T2N0M0 oesophageal cancer 
    Markar, Sheraz R.; Gronnier, Caroline; Pasquer, Arnaud; Duhamel, Alain; Beal, Hélène; Théreaux, Jérémie; Gagnière, Johan; Lebreton, Gil; Brigand, Cécile; Meunier, Bernard; Collet, Denis; Mariette, Christophe (2022-11-04)
    Aims The aims of this study were to compare short- and long-term outcomes for clinical T2N0 oesophageal cancer with analysis of (i) primary surgery (S) versus neoadjuvant therapy plus surgery (NS), (ii) squamous cell ...
  • Self-Expanding Covered Metallic Stent as a Bridge to Surgery in Esophageal Cancer 
    Mariette, Christophe; Gronnier, Caroline; Duhamel, Alain; Mabrut, Jean-Yves; Bail, Jean-Pierre; Carrere, Nicolas; Lefevre, Jérémie H.; Meunier, Bernard; Collet, Denis; Piessen, Guillaume (2022-11-04)
    Background Self-expanding metallic stents (SEMSs) have been used as a bridge to surgery, relieving dysphagia and maintaining nutrition, in patients with operable but obstructive esophageal cancer (EC). However, the impact ...
  • Diagnostic markers of postoperative morbidity after laparoscopic Roux-en-Y gastric bypass for obesity 
    Romain, Benoît; Chemaly, Rodrigue; Meyer, Nicolas; Chilintseva, Natalia; Triki, Elhocine; Brigand, Cécile; Rohr, Serge (2022-11-04)
    Purpose The main objective of this study was to detect subacute complications that can arise from laparoscopic Roux-en-Y gastric bypass and take a rational approach to manage these complications. Methods A prospective ...
  • Pattern of Postoperative Mortality After Esophageal Cancer Resection According to Center Volume 
    Markar, Sheraz; Gronnier, Caroline; Duhamel, ala; Bigourdan, Jean-Marc; Badic, Bogdan; Du Rieu, Mael Chalret; Lefevre, Jérémie H.; Turner, Kathleen; Luc, Guillaume; Mariette, Christophe (2022-11-03)
    Background High center procedural volume has been shown to reduce postoperative mortality (POM); however, the cause of POM has been poorly studied previously. The aim of this study was to define the pattern of POM and ...
  • Incidence and Risk Factors Related to Symptomatic Venous Thromboembolic Events After Esophagectomy for Cancer 
    Mantziari, Styliani; Gronnier, Caroline; Pasquer, Arnaud; Gagnière, Johan; Théreaux, Jérémie; Demartines, Nicolas; Schäfer, Markus; Mariette, Christophe (2022-11-03)
    Background Major oncologic surgery is associated with a high incidence of venous thromboembolic events (VTE), including deep venous thrombosis (DVT) and pulmonary embolism (PE). However, the incidence and risk factors for ...
  • Salvage surgery after chemoradiotherapy in the management of esophageal cancer 
    Markar, Sheraz; Gronnier, Caroline; Duhamel, Alain; Pasquer, Arnaud; Théreaux, Jérémie; Du Rieu, Mael Chalret; Lefevre, Jérémie H.; Turner, Kathleen; Luc, Guillaume; Mariette, Christophe (2022-11-03)
    Purpose: The aim of this large multicenter study was to assess the impact of salvage esophagectomy after definitive chemoradiotherapy (SALV) on clinical outcome. Patients and methods: Data from consecutive adult patients ...
  • Predictive factors of recurrence in patients with pathological complete response after esophagectomy following neoadjuvant chemoradiotherapy for esophageal cancer 
    Luc, Guillaume; Gronnier, Caroline; Lebreton, Gil; Brigand, Cecile; Mabrut, Jean-Yves; Bail, Jean-Pierre; Bernard, Meunier; Collet, Denis; Mariette, Christophe (2022-11-03)
    Background Minimal data have previously emerged from studies regarding the factors associated with recurrence in patients with ypT0N0M0 status. The purpose of the study was to predict survival and recurrence in patients ...
  • Impact of adjuvant chemotherapy on patients with lymph node-positive esophageal cancer who are primarily treated with surgery 
    Pasquer, Arnaud; Gronnier, Caroline; Renaud, Florence; Duhamel, Alain; Théreaux, Jérémie; Carrere, Nicolas; Gagniere, Johan; Meunier, Bernard; Collet, Denis; Mariette, Christophe (2022-11-03)
    Background: Whereas the optimal therapeutic strategy in node positive esophageal cancer primarily treated by surgery remains unknown, the study was designed to evaluate the impact of adjuvant chemotherapy on survival in ...
  • Significance of microscopically incomplete resection margin after esophagectomy for esophageal cancer 
    Markar, Sheraz R.; Gronnier, Caroline; Duhamel, Alain; Pasquer, Arnaud; Théreaux, Jérémie; Du Rieu, Mael Chalret; Lefevre, Jérémie H.; Turner, Kathleen; Luc, Guillaume; Mariette, Christophe (2022-11-03)
    Objective: The objectives of this study were to establish if R1 resection margin after esophagectomy was (i) a poor prognostic factor independent of patient and tumor characteristics, (ii) a marker of tumor aggressiveness ...
  • Survival Benefit of Neoadjuvant Treatment in Clinical T3N0M0 Esophageal Cancer 
    Mantziari, Styliani; Gronnier, Caroline; Renaud, Florence; Duhamel, Alain; Théreaux, Jérémie; Brigand, Cécile; Carrère, Nicolas; Lefevre, Jérémie H.; Pasquer, Arnaud; Demartines, Nicolas; Collet, Denis; Meunier, Bernard; Mariette, Christophe (2022-11-02)
    Background: Based on current guidelines, clinical T3N0M0 esophageal tumors may or may not receive neoadjuvant treatment, according to their perception as locally advanced (cT3) or early-stage tumors (stage II). The study ...
  • Salvage surgery for esophageal cancer 
    Cohen, Charlotte; Tessier, Williams; Gronnier, Caroline; Renaud, Florence; Pasquer, Arnaud; Théreaux, Jérémie; Gagniere, Johan; Meunier, Bernard; Collet, Denis; Piessen, Guillaume; Mariette, Christophe (2022-11-02)
    Background Locoregional recurrence rates after definitive chemoradiotherapy (dCRT) for locally advanced esophageal cancer (EC) are high. Salvage surgery (SALV) is considered the best treatment option in case of persistent ...
  • Autologous adipose-derived mesenchymal stem cells embedded in platelet-rich fibrin in diabetic foot ulcers 
    Khalil, Charbel; Chaker, Diana; Salameh, Rawad; Germanos, Yvonne-Elise; El Kayem, Elie; Nader, Fady; Habbouche, Jessica; Chemaly, Rodrigue; Azar, Albert; Ibrahim, Ahmad (2022-11-02)
    Context and Aim: Mesenchymal stem cells (MSCs) and platelet-rich fibrin (PRF) have emerged as ideal candidates for advanced therapies of various therapeutically-challenging diseases; however, their regenerative potential ...
  • Gastroesophageal Cancer After Gastric Bypass Surgeries 
    Chemaly, Rodrigue; Diab, Samer; Khazen, Georges; Al-Hajj, Georges (2022-11-01)
    Data comparing the occurrence of gastroesophageal cancer after gastric bypass procedures are lacking and are only available in the form of case reports. We perform in this study a systematic review and a meta-analysis of ...
  • Visual recovery after impalement injury of the orbit by reinforced steel bar 
    Mansour, Ahmad M.; Al-Salem, Khalil Mahmoud; Haddad, Sandra; Mollayess, Georges (2022-11-01)
    Impalement injuries to the head and neck are quite rare, commonly lethal, and vision threatening when involving the orbit. Here, a case of impalement injury involving a steel bar to the neck and left orbit with full visual ...

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