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Gilbert and Rose-Marie Chagoury School of Medicine: Recent submissions

  • Higher serum leptin level in women than in nen with type 1 diabetes 
    Azar, Sami T.; Salti, Ibrahim; Zantout, Mira S.; Shahine, Carmen H.; Zalloua, Pierre A. (2019-07-19)
    Leptin is the protein product of the obese (ob) gene, a lipostatic hormone that contributes to body weight regulation through suppressing appetite and/or stimulating energy expenditure in humans and/or rodents. In humans, ...
  • Molecular basis of oculocutaneous albinism type 1 in Lebanese patients 
    Zahed, Laila; Zahreddine, Hala; Noureddine, Baha'; Rebeiz, Nelly; Shakar, Nadine; Zalloua, Pierre; Haddad, Fadi (2019-07-19)
    Oculocutaneous albinism type 1 (OCA1) results from mutations in the tyrosinase gene, which lead to partial or complete loss of activity of the corresponding enzyme. A large number of mutations have been identified worldwide, ...
  • Origin and history of the IVS-I-110 and codon 39 [beta]-thalassemia mutations in the Lebanese population 
    Zahed, Laila; Demont, Jocelyne; Bouhass, Rachid; Trabuchet, Guy; Hanni, Catherine; Zalloua, Pierre; Perrin, Pascale (2019-07-19)
    Using restriction fragment length polymorphisms (RFLPs) and sequence haplotype analysis, we studied the chromosomal background of the β-globin gene in 31 unrelated Lebanese IVS-I-110 or codon 39 (Cd39) subjects, and five ...
  • The DD genotype of the ACE gene polymorphism is associated with diabetic nephropathy in type-1 diabetics 
    Azar, Sami T.; Zalloua, Pierre A.; Medlej, Rita; Halabi, George (2019-07-19)
    Genetic factors are involved in the development of diabetic nephropathy in type-1 diabetes. We are examining the association of the angiotensin-converting enzyme (ACE), insertion/deletion (I/D) polymorphism with the presence ...
  • Zidovudine and interferon-α treatment induces a high response rate and reduces HTLV-1 proviral load and VEGF plasma levels in patients with adult T-cell leukemia from North East Iran 
    Kchour, Ghada; Makhoul, Nadine J.; Mahmoudi, Mahmoud; Kooshyar, Mohamad-Mehdi; Shirdel, Abbas; Rastin, Mayram; Rafatpanah, Houshang; Tarhini, Mahdi; Zalloua, Pierre A.; Farid, Reza; Bazarbachi, Ali (2019-07-19)
    Human T-cell lymphotropic virus type I (HTLV-I) associated adult T-cell leukemia/lymphoma (ATLL) is endemic in southern Japan, the Caribbean, intertropical Africa, and Brazil. Recently north east Iran, particularly the ...
  • Predictors of coronary artery disease in the Lebanese population 
    Abchee, Antoine; Puzantian, Houry; Azar, Sami T.; Shbaklo, Hadia; Nasrallah, Antoine; Sawaya, Fadi J.; Alam, Samir; Zalloua, Pierre A. (2019-07-19)
    Background Coronary artery disease (CAD) is one of the major causes of morbidity and mortality in the world. The disease is determined by many risk factors such as age, gender, diabetes, dyslipidemia, smoking, as well as ...
  • Chemical cleavage of 5′-linked protein from tobacco ringspot virus genomic RNAs and characterization of the protein–RNA linkage 
    Zalloua, Pierre A.; Buzayan, Jamal M.; Bruening, George (2019-07-19)
    Each of the two genomic RNAs of tobacco ringspot nepovirus is known to have a 5′-linked protein, the VPg. We report a simplified analysis of the covalent VPg-RNA connection that allowed us to identify the 5′ nucleotide ...
  • Parallel evolution of genes and languages in the Caucasus region 
    Balanovsky, Oleg; Dibirova, Khadizhat; Dybo, Anna; Mudrak, Oleg; Frolova, Svetlana; Pocheshkhova, Elvira; Haber, Marc; Platt, Daniel; Schurr, Theodore; Haak, Wolfgang; Kuznetsova, Marina; Magomed, Radzhadov; Balaganskaya, Olga; Romanov, Alexey; Renfrew, Colin; Wells, R.Spencer; Tyler-Smith, Chris; Balanovsky, Elena (2019-07-19)
    We analyzed 40 single nucleotide polymorphism and 19 short tandem repeat Y-chromosomal markers in a large sample of 1,525 indigenous individuals from 14 populations in the Caucasus and 254 additional individuals representing ...
  • Characterization of a large Lebanese family segregating IgA nephropathy 
    Karnib, Hussein H.; Sanna-Cherchi, Simone; Zalloua, Pierre A.; Medawar, Walid; D'Agati, Vivette D.; Lifton, Richard P.; Badr, Kamal; Gharavi, Ali G. (2019-07-19)
    Background. Familial aggregation of IgA nephropathy (IgAN) suggests that genetic factors contribute to the development of this trait. Because clinical manifestations in IgAN families are often limited to episodic haematuria, ...
  • Effective treatment of hypereosinophilic syndrome with imatinib mesylate 
    Salem, Ziad; Zalloua, Pierre A.; Chehali, Aref; Bitar, Nizar; Abboud, Miguel; kadri, Adel; Chami, Beatrice; Bazarbachi, Ali (2019-07-19)
    Imatinib mesylate treatment is highly effective in chronic myeloid leukaemia and recent data have suggested that imatinib mesylate is also effective in the treatment of idiopathic hypereosinophilicsyndrome (HES). Six ...
  • Identifying genetic traces of historical expansions 
    Zalloua, Pierre A.; Platt, Daniel E.; El Sibai, Mirvat; Khalife, Jade; Makhoul, Nadine; Haber, Marc; Xue, Yali; Izaabel, Hassan; Bosch, Elena; Adams, Susan M.; Arroyo, Eduardo; Lopez-Parra, Ana Maria; Aler, Mercedes; Picornell, Antonia; Ramon, Misericordia; Jobling, Mark A.; Comas, David; Bertranpetit, Jaume; Tyler-Smith, Chris (2019-07-18)
    The Phoenicians were the dominant traders in the Mediterranean Sea two thousand to three thousand years ago and expanded from their homeland in the Levant to establish colonies and trading posts throughout the Mediterranean, ...
  • Impact of seafood and fruit consumption on bone mineral density 
    Zalloua, Pierre A.; Hsu, Yi-Hsiang; Terwedow, Henry; Zang, Tonghua; Tang, Genfu; Li, Zhiping; Hong, Xiumei; Azar, Sami T.; Wang, Binyan; Bouxsein, Mary L.; Brain, Joseph; Cummings, Steven R.; Rosen, Clifford J.; Xu, Xiping (2019-07-18)
    Objectives Over the past decade, dietary choices and nutrition have proven to be major modulators of bone mineral density (BMD) in men and women. We investigated environmental determinants, specifically dietary habits, ...
  • Y-chromosomal diversity in Lebanon is structured by recent historical events 
    Zalloua, Pierre A.; Xue, Yali; Khalife, Jade; Makhoul, Nadine; Debiane, Labib; Platt, Daniel E.; Royyuru, Aya K.; Herrera, Rene J.; Hernanz, David F. Soria; Blue-Smith, Jason; Wells, R. Spencer; Comas, David; Bertranpetit, Jaune; Tyler-Smith, Chris (2019-07-18)
    Lebanon is an eastern Mediterranean country inhabited by approximately four million people with a wide variety of ethnicities and religions, including Muslim, Christian, and Druze. In the present study, 926 Lebanese men ...
  • Arsenic/interferon specifically reverses 2 distinct gene networks critical for the survival of HTLV-1–infected leukemic cells 
    Nasr, Rihab; Rosenwald, Andreas; El-Sabban, Marwan E.; Arnulf, Bertrand; Zalloua, Pierre; Lepelletier, Yves; Bex, Francoise; Hermine, Olivier; Staudt, Louis; de The, Hugues; Bazarbachi, Ali (2019-07-18)
    Adult T-cell leukemia (ATL) is a severe chemotherapy-resistant malignancy associated with prolonged infection by the human T cell-lymphotropic virus 1 (HTLV-1) retrovirus. Although the Tax viral transactivator is clearly ...
  • The Eurasian Heartland 
    Spencer-Wells, R.; Yuldasheva, Nadira; Ruzibakiev, Ruslan; Underhill, Peter A.; Evseeva, Irina; Blue-Smith, Jason; Jin, Li; Su, Bing; Pitchappan, Ramasamy; Shanmugalakshmi, Sadagopal; Balakrishnan, Karuppiah; Read, Mark; Pearson, Nathaniel M.; Zerjal, Tatiana; Webster, Matthew T.; Zholoshvili, Iraki; Jamarjashvili, Elena; Gambarov, Spartak; Nikbin, Behrouz; Dostiev, Ashur; Aknazarov, Ogonazar; Zalloua, Pierre; Tsoy, Igor; Kitaev, Mikhali; Mirrakhimov, Mirsaid; Chariev, Ashir; Bodmer, Walter F. (2019-07-18)
    The nonrecombining portion of the human Y chromosome has proven to be a valuable tool for the study of population history. The maintenance of extended haplotypes characteristic of particular geographic regions, despite ...
  • Computer-aided planning for endovascular treatment of intracranial aneurysms (CAPETA) 
    Mohamed, Ashraf; Sgouritsa, Eleni; Morsi, Hesham; Shaltoni, Hashem; Mawad, Michel E.; Kakadiaries, Ioannis A. (SPIE, 2019-07-12)
    Endovascular treatment planning of intracranial aneurysms requires accurate quantification of their geometric parameters, including the neck length, dome height and maximum diameter. Today, the geometry of intracranial ...
  • Reconstruction of the basilar tip with T stent configuration for treatment of a wide-neck aneurysm 
    Akpek, Sergin; Morsi, Hesham; Benndorf, Goetz; Strother, Charles M.; Mawad, Michel E. (2019-07-12)
  • Extracranial traumatic carotid artery dissections in children 
    Chamoun, Roukoz B.; Mawad, Michel E.; Whitehead, William E.; Luerssen, Thomas G.; Jea, Andrew (2019-07-12)
    Object Currently, no diagnostic or treatment standards exist for extracranial carotid artery dissection (CAD) in children after trauma. The purpose of this study was to review and describe the characteristics, diagnosis, ...
  • The wingspan stent system for the treatment of intracranial atherosclerotic stenoses. 
    Lee, Doek Hee; Morsi, Hesham; Daza, Orlando Diaz; Arat, Anit (2019-07-12)
    PURPOSE A self-expandable nitinol stent (WingSpan stent; Boston Scientific Corp.) was introduced for the treatment of intracranial stenoses. The purpose of this study is to present our initial experience with the WingSpan ...
  • Endovascular recanalization in acute ischemic stroke using the solitaire FR revascularization device with adjunctive C-arm CT imaging 
    Mitchell, B.D.; Chinnadurai, P.; Chintalapani, G.; Morsi, H.A.; Shaltoni, H.; Mawad, M.E. (2019-07-12)
    In this clinical report, we examined a single-center experience by using the Solitaire FR Revascularization Device in the treatment of acute ischemic stroke in which there was poor initial visualization of the occluded ...

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