.

Recently added

LAUR Repository

Gilbert and Rose-Marie Chagoury School of Medicine: Recent submissions

  • Health system resilience 
    Ammar, Walid; Kdouh, Ola; Hammoud, Rawan; Hamadeh, Randa; Harb, Hilda; Ammar, Zeina; Atun, Rifat; Christiani, David; Zalloua, Pierre A. (2019-07-25)
    Background Between 2011 and 2013, the Lebanese population increased by 30% due to the influx of Syrian refugees. While a sudden increase of such magnitude represents a shock to the health system, threatening the continuity ...
  • Large-scale association analysis identifies new risk loci for coronary artery disease 
    Deloukas, Panos; Zalloua, Pierre A. (2019-07-25)
    Coronary artery disease (CAD) is the commonest cause of death. Here, we report an association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching genome-wide significance, taking the number of ...
  • Genetic heterogeneity of beta thalassemia in Lebanon reflects historic and recent population migration 
    Makhoul, N.J.; Wells, R.S.; Kaspart, H.; Shbaklo, H.; Taher, A.; Chakar, N.; Zalloua, P.A. (2019-07-25)
    Beta thalassemia is an autosomal recessive disorder characterized by reduced (β+) or absent (β0) beta‐globin chain synthesis. In Lebanon it is the most predominant genetic defect. In this study we investigated the religious ...
  • Afghanistan's ethnic groups share a Y-chromosomal heritage structured by historical events 
    Haber, Marc; Platt, Daniel E.; Bonab, Maziar Ashrafian; Youhanna, Sonia C.; Soria-Hernanz, David F.; Martínez-Cruz, Begona; Douaihy, Bouchra; Ghassibe-Sabbagh, Michella; Rafatpanah, Hoshang; Ghanbari, Mohsen; Whale, John; Balanovsky, Oleg; Spencer Wells, R.; Comas, David; Tyler-Smith, Chris; Zalloua, Pierre A. (2019-07-25)
    Afghanistan has held a strategic position throughout history. It has been inhabited since the Paleolithic and later became a crossroad for expanding civilizations and empires. Afghanistan's location, history, and diverse ...
  • 956. Imaging of radiation-inducible promotersu using a naturally secreted luciferase from the Marine copepod gaussia princeps 
    Badr, Christian E.; Zalloua, Pierre; Breakefield, Xandra O.; Tannous, Bakhos A. (2019-07-22)
    Ionizing Radiation (IR)-inducible promoters used as genetic switches for cancer therapy are promising tool for controlling therapeutic gene expression. Here we describe the use of a naturally secreted luciferase from the ...
  • mtDNA lineages reveal coronary artery disease‐associated structures in the Lebanese population 
    Haber, Marc; Youhanna, Sonia C.; Balanovsky, Oleg; Saade, Stephanie; Martínez‐Cruz, Begona; Ghassibe-Sabbagh, Michella; Shasha, Nabil; Osman, Raed; El Bayeh, Hamid; Koshel, Sergey; Zaporozhchenko, Valery; Balanovska, Elena; Soria‐Hernanz, David F.; Platt, Daniel E. (2019-07-22)
    Population origins and ancestry have previously been found to be important determinants of coronary artery disease (CAD). This study investigates associations of Lebanese mitochondrial DNA lineages with CAD and studies ...
  • Y-chromosome R-M343 African lineages and sickle cell disease reveal structured assimilation in Lebanon 
    Haber, Marc; Platt, Daniel E.; Khoury, Simon; Badro, Danielle A.; Abboud, Miguel; Tyler-Smith, Chris; Zalloua, Pierre (2019-07-22)
    We have sought to identify signals of assimilation of African male lines in Lebanon by exploring the association of sickle cell disease (SCD) in Lebanon with Y-chromosome haplogroups that are informative of the disease ...
  • Recombination networks as genetic markers in a human variation study of the Old World 
    Javed, Asif; Mele, Marta; Pybus, Marc; Zalloua, Pierre; Haber, Marc; Comas, David; Netea, Mihai G.; Balanovsky, Oleg; Balanovsky, Elena; Jin, Li; Yang, Yajun; ArunKumar, GaneshPrasad; Pitchappan, Ramasamy; Bertranpetit, Jaume; Calafell, Francesc (2019-07-22)
    We have analyzed human genetic diversity in 33 Old World populations including 23 populations obtained through Genographic Project studies. A set of 1,536 SNPs in five X chromosome regions were genotyped in 1,288 individuals ...
  • Prevalence of asthmatic symptoms in Lebanese patients with type 1 diabetes and their unaffected siblings compared to age-matched controls 
    Taleb, Nadine; Bou Khalil, Pierre; Zantout, Mira S.; Zalloua, Pierre; Azar, Sami T. (2019-07-22)
    Patients with type 1 diabetes (a TH1 disease) have been reported to be at a lower risk of developing asthma (a TH2 disease). Both diseases are affected by environmental and genetic factors. Our objective is to examine this ...
  • Improved quality of 1H NMR spectroscopic data for enhanced metabolic profiling of low molecular weight metabolites in human serum Authors Authors and affiliations 
    Stolzenburg, Svenja; Lauridsen, Micheal B.; Toft, Henrik; Zalloua, Pierre A.; Baunsgaard, Dorrit (2019-07-22)
    NMR based metabolic profiling of blood samples in epidemiological studies can be used for molecular phenotyping and biomarker discovery. Often metabolic changes in blood are more subtle and demand a high quality spectrum ...
  • The codons 8/9 (+ G) mutation found for the first time in the Lebanese population 
    Zalloua, Pierre A.; Aoun, Elie; Koussa, Suzanne; Asfahani, Wissam S.Z.; Taher, Ali (2019-07-22)
    Thalassemia is a common inherited disease in the Mediterranean region. We here report a mutation new to the Lebanese population: the insertion of a G nucleotide at codons 8/9 [(+G) AAG‐TCT (Lys‐Ser)→AAG‐G‐TCT (β0)] of the ...
  • Nicotine metabolism in healthy smokers and patients with cardiovascular diseases 
    Chahine, Ramez; Abchee, Antoine; Zalloua, Pierre (2019-07-22)
    In this study, we measured the excretion rate of nicotine and its two major metabolites, cotinine and trans-3′-hydroxycotinine (THOC), in the urine of 25 healthy smokers and 15 smokers who underwent a coronary artery bypass ...
  • Accurate and rapid prenatal diagnosis of the most frequent East Mediterranean β‐thalassemia mutations 
    Naja, R.P.; Kaspar, H.; Shbaklo, H.; Chakar, N.; Makhoul, N.J.; Zalloua, P.A. (2019-07-22)
    β‐Thalassemia is the most common genetic disorder in the Lebanese population. Of the 200 different mutations in the β‐globin gene that leads to thalassemia, the IVSI‐110 (29.87%), IVSI‐6 (20.74%), IVSI‐1 (14.07%), IVSII‐1 ...
  • Prenatal and neonatal Group B Streptococcus screening and serotyping in Lebanon 
    Seoud, Muheiddine; Nassar, Anwar H.; Zalloua, Pierre; Boghossian, Nansi; Ezeddine, Jihad; Fakhoury, Hassan; Araj, George; Nacouzi, Ghinwa; Sanyoura, May; Yunis, Khalid (2019-07-22)
    The study aimed at determining the prevalence, risk factors, perinatal transmission, and serotypes of Group B Streptococcus (GBS) among pregnant women and their newborns in Beirut, Lebanon. This was a cross-sectional study ...
  • Recombination gives a new insight in the effective population size and the history of the old world human populations 
    Mele, Marta; Javed, Asif; Pybus, Marc; Zalloua, Pierre; Haber, Marc; Comas, David; Netea, Mihai G.; Balamovsky, Oleg; Balanovska, Elena; Jin, Li; Yang, Yajun; Pitchappan, R.M.; Arunkumar, G.; Parida, Laxmi; Calafell, Francesc; Bertranpetit, Jaume (2019-07-22)
    The information left by recombination in our genomes can be used to make inferences on our recent evolutionary history. Specifically, the number of past recombination events in a population sample is a function of its ...
  • Consanguinity 
    Mumtaz, Ghina; Nassar, Anwar H.; Mahfoud, Ziyad; El-Khamra, Akaber; Al-Choueiri, Nathalie; Adra, Abdallah; Murray, Jeffrey C.; Zalloua, Pierre; Yunis, Khalid A. (2019-07-22)
    Consanguinity promotes homozygosity of recessive susceptibility gene variants and can be used to investigate a recessive component in diseases whose inheritance is uncertain. The objective of this study was to assess the ...
  • No association between the −1031 polymorphism in the TNF-α promoter region and type 1 diabetes 
    Shbaklo, Hadia; Azar, Sami T.; Terwedow, Henry; Halaby, Georges; Naja, Roy P.; Zalloua, Pierre A. (2019-07-22)
    Tumor necrosis factor alpha (TNF-α) is an important immunomodulator and is believed to be involved in the development or progression of type 1 diabetes. In the following study, we evaluated TNF-α promoter ...
  • Novel mutation causing partial biotinidase deficiency in a Syrian boy with infantile spasms and retardation 
    Mikati, Mohamad A.; Zalloua, Pierre; Karam, Pascale (2019-07-22)
    We report a case of partial biotinidase deficiency (plasma biotinidase levels: 1.30 nm/minute/mL) in a 7-month-old boy who presented with evidence of perinatal distress followed by developmental delay, hypotonia, seizures, ...
  • Genomic ancestry of North Africans supports back-to-Africa migrations 
    Henn, Brenna M.; Botigue, Laura R.; Gravel, Simon; Wang, Wei; Brisbin, Abra; Byrnes, Abra; Bymes, Jake K.; Fadhlaoui-Zid, Karina; Zalloua, Pierre A.; Moreno-Estrada, Andres; Bertranpetit, Jaume; Bustamante, Carlos D.; Comas, David (2019-07-19)
    North African populations are distinct from sub-Saharan Africans based on cultural, linguistic, and phenotypic attributes; however, the time and the extent of genetic divergence between populations north and south of the ...
  • Increase of satellite tobacco ringspot virus RNA initiated by inoculating circular RNA 
    Buzayan, Jamal M.; Tol, Hans Van; Zalloua, Pierre A.; Bruening, George (2019-07-19)
    A small satellite RNA of tobacco ringspot virus (sTRSV RNA) generates circular and linear molecules of unit length and repetitive sequence, linear multimers during replication. The phosphodiester junction joining the unit ...

Search LAUR


Advanced Search

Browse

My Account