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Browsing Gilbert and Rose-Marie Chagoury School of Medicine by Author "Zalloua, Pierre"

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Browsing Gilbert and Rose-Marie Chagoury School of Medicine by Author "Zalloua, Pierre"

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  • 956. Imaging of radiation-inducible promotersu using a naturally secreted luciferase from the Marine copepod gaussia princeps 
    Badr, Christian E.; Zalloua, Pierre; Breakefield, Xandra O.; Tannous, Bakhos A. (2019-07-22)
    Ionizing Radiation (IR)-inducible promoters used as genetic switches for cancer therapy are promising tool for controlling therapeutic gene expression. Here we describe the use of a naturally secreted luciferase from the ...
  • Arsenic/interferon specifically reverses 2 distinct gene networks critical for the survival of HTLV-1–infected leukemic cells 
    Nasr, Rihab; Rosenwald, Andreas; El-Sabban, Marwan E.; Arnulf, Bertrand; Zalloua, Pierre; Lepelletier, Yves; Bex, Francoise; Hermine, Olivier; Staudt, Louis; de The, Hugues; Bazarbachi, Ali (2019-07-18)
    Adult T-cell leukemia (ATL) is a severe chemotherapy-resistant malignancy associated with prolonged infection by the human T cell-lymphotropic virus 1 (HTLV-1) retrovirus. Although the Tax viral transactivator is clearly ...
  • Consanguinity 
    Mumtaz, Ghina; Nassar, Anwar H.; Mahfoud, Ziyad; El-Khamra, Akaber; Al-Choueiri, Nathalie; Adra, Abdallah; Murray, Jeffrey C.; Zalloua, Pierre; Yunis, Khalid A. (2019-07-22)
    Consanguinity promotes homozygosity of recessive susceptibility gene variants and can be used to investigate a recessive component in diseases whose inheritance is uncertain. The objective of this study was to assess the ...
  • The consanguinity effect on QF‐PCR diagnosis of autosomal anomalies 
    Choueiri, Michel; Makhoul, Nadine; Zreik, Tony; Mattar, Farid; Eid, Raymond; Mroueh, Adnan; Zalloua, Pierre (2015-10-07)
    Objectives Quantitative Fluorescent PCR (QF-PCR) is a simpler and faster method of detecting common chromosomal abnormalities when compared to cytogenetic analysis. The aim of our study is to investigate the applicability ...
  • The Eurasian Heartland 
    Spencer-Wells, R.; Yuldasheva, Nadira; Ruzibakiev, Ruslan; Underhill, Peter A.; Evseeva, Irina; Blue-Smith, Jason; Jin, Li; Su, Bing; Pitchappan, Ramasamy; Shanmugalakshmi, Sadagopal; Balakrishnan, Karuppiah; Read, Mark; Pearson, Nathaniel M.; Zerjal, Tatiana; Webster, Matthew T.; Zholoshvili, Iraki; Jamarjashvili, Elena; Gambarov, Spartak; Nikbin, Behrouz; Dostiev, Ashur; Aknazarov, Ogonazar; Zalloua, Pierre; Tsoy, Igor; Kitaev, Mikhali; Mirrakhimov, Mirsaid; Chariev, Ashir; Bodmer, Walter F. (2019-07-18)
    The nonrecombining portion of the human Y chromosome has proven to be a valuable tool for the study of population history. The maintenance of extended haplotypes characteristic of particular geographic regions, despite ...
  • Fertility drugs and the risk of breast cancer 
    Zreik, Tony; Mazloom, Ali; Vannucci, Marina; Pinnix, Chilsea; Fulton, Stephanie; Hadziahmetovic, Mersiha; Asmar, Nadia; Munkarah, Adnan; Ayoub, Chakib M.; Shihadeh, Ferial; Berjawi, Ghina; Hannoun, Antoine; Zalloua, Pierre; Wogan, Christine; Dabaja, Bouthaina (2015-10-07)
    The risk of breast cancer has been associated with reproductive history. The purpose of this study was to determine the relationship between fertility drugs used in assisted reproductive procedures and the risk of breast ...
  • Juvenile-onset diabetes and congenital cataract 
    Lenfant, Caroline; Baz, Patrick; Degavre, Anne; Phillippi, Anne; Senne, Valerie; Vandiedonck, Claire; Derbois, Celine; Nicolino, Marc; Zalloua, Pierre; Julier, Cecile (2019-07-25)
    Monogenic forms of diabetes may account for 1–5% of all cases of diabetes, and may occur in the context of syndromic presentations. We investigated the case of a girl affected by insulin-dependent diabetes, diagnosed at 6 ...
  • Molecular basis of oculocutaneous albinism type 1 in Lebanese patients 
    Zahed, Laila; Zahreddine, Hala; Noureddine, Baha'; Rebeiz, Nelly; Shakar, Nadine; Zalloua, Pierre; Haddad, Fadi (2019-07-19)
    Oculocutaneous albinism type 1 (OCA1) results from mutations in the tyrosinase gene, which lead to partial or complete loss of activity of the corresponding enzyme. A large number of mutations have been identified worldwide, ...
  • Nicotine metabolism in healthy smokers and patients with cardiovascular diseases 
    Chahine, Ramez; Abchee, Antoine; Zalloua, Pierre (2019-07-22)
    In this study, we measured the excretion rate of nicotine and its two major metabolites, cotinine and trans-3′-hydroxycotinine (THOC), in the urine of 25 healthy smokers and 15 smokers who underwent a coronary artery bypass ...
  • Novel mutation causing partial biotinidase deficiency in a Syrian boy with infantile spasms and retardation 
    Mikati, Mohamad A.; Zalloua, Pierre; Karam, Pascale (2019-07-22)
    We report a case of partial biotinidase deficiency (plasma biotinidase levels: 1.30 nm/minute/mL) in a 7-month-old boy who presented with evidence of perinatal distress followed by developmental delay, hypotonia, seizures, ...
  • Origin and history of the IVS-I-110 and codon 39 [beta]-thalassemia mutations in the Lebanese population 
    Zahed, Laila; Demont, Jocelyne; Bouhass, Rachid; Trabuchet, Guy; Hanni, Catherine; Zalloua, Pierre; Perrin, Pascale (2019-07-19)
    Using restriction fragment length polymorphisms (RFLPs) and sequence haplotype analysis, we studied the chromosomal background of the β-globin gene in 31 unrelated Lebanese IVS-I-110 or codon 39 (Cd39) subjects, and five ...
  • Parental consanguinity and family history of coronary artery disease strongly predict early stenosis 
    Deeb, Mary E.; Zreik, Tony G.; Zalloua, Pierre; Youhanna, Sonia; Platt, Daniel E.; Rebeiz, Abdallah; Lauridsen, Michael; Nasrallah, Antoine; Alam, Samir; Puzantian, Houry; Kabbani, Samer (2016-11-18)
    Background Coronary artery disease (CAD) is a multifactorial disease with acquired and inherited components. Aim We investigated the roles of family history and consanguinity on CAD risk and age at diagnosis in ...
  • Patients with early onset of type 1 diabetes have significantly higher GG genotype at position 49 of the CTLA4 gene 
    Zalloua, Pierre; Abchee, Antoine; Shbaklo, Hadia; Zreik, Tony; Terwedow, Henry; Halaby, Georges; Azar, Sami (2015-10-06)
    Type 1 diabetes (T1D) is a complex autoimmune disease. Several genetic loci have been implicated in the susceptibility to this illness. Evaluated was the role of the CTLA4 exon 1 A49G polymorphism and its role as a risk ...
  • Prenatal and neonatal Group B Streptococcus screening and serotyping in Lebanon 
    Seoud, Muheiddine; Nassar, Anwar H.; Zalloua, Pierre; Boghossian, Nansi; Ezeddine, Jihad; Fakhoury, Hassan; Araj, George; Nacouzi, Ghinwa; Sanyoura, May; Yunis, Khalid (2019-07-22)
    The study aimed at determining the prevalence, risk factors, perinatal transmission, and serotypes of Group B Streptococcus (GBS) among pregnant women and their newborns in Beirut, Lebanon. This was a cross-sectional study ...
  • Prevalence of asthmatic symptoms in Lebanese patients with type 1 diabetes and their unaffected siblings compared to age-matched controls 
    Taleb, Nadine; Bou Khalil, Pierre; Zantout, Mira S.; Zalloua, Pierre; Azar, Sami T. (2019-07-22)
    Patients with type 1 diabetes (a TH1 disease) have been reported to be at a lower risk of developing asthma (a TH2 disease). Both diseases are affected by environmental and genetic factors. Our objective is to examine this ...
  • Recombination gives a new insight in the effective population size and the history of the old world human populations 
    Mele, Marta; Javed, Asif; Pybus, Marc; Zalloua, Pierre; Haber, Marc; Comas, David; Netea, Mihai G.; Balamovsky, Oleg; Balanovska, Elena; Jin, Li; Yang, Yajun; Pitchappan, R.M.; Arunkumar, G.; Parida, Laxmi; Calafell, Francesc; Bertranpetit, Jaume (2019-07-22)
    The information left by recombination in our genomes can be used to make inferences on our recent evolutionary history. Specifically, the number of past recombination events in a population sample is a function of its ...
  • Recombination networks as genetic markers in a human variation study of the Old World 
    Javed, Asif; Mele, Marta; Pybus, Marc; Zalloua, Pierre; Haber, Marc; Comas, David; Netea, Mihai G.; Balanovsky, Oleg; Balanovsky, Elena; Jin, Li; Yang, Yajun; ArunKumar, GaneshPrasad; Pitchappan, Ramasamy; Bertranpetit, Jaume; Calafell, Francesc (2019-07-22)
    We have analyzed human genetic diversity in 33 Old World populations including 23 populations obtained through Genographic Project studies. A set of 1,536 SNPs in five X chromosome regions were genotyped in 1,288 individuals ...
  • Screening for antiretroviral drug resistance among treatment-naive human immunodeficiency virus type 1-infected individuals in Lebanon 
    Mokhbat, Jacques M.; Zalloua, Pierre; Melhem, Nada M.; El-Khatib, Ziad (2019-04-17)
    Introduction: Antiretroviral therapy (ART) has been successful at decreasing the morbidity and mortality associated with human immunodeficiency virus type 1 (HIV-1) infection. HIV-1 drug resistance ...
  • Y-chromosome R-M343 African lineages and sickle cell disease reveal structured assimilation in Lebanon 
    Haber, Marc; Platt, Daniel E.; Khoury, Simon; Badro, Danielle A.; Abboud, Miguel; Tyler-Smith, Chris; Zalloua, Pierre (2019-07-22)
    We have sought to identify signals of assimilation of African male lines in Lebanon by exploring the association of sickle cell disease (SCD) in Lebanon with Y-chromosome haplogroups that are informative of the disease ...

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