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Browsing Gilbert and Rose-Marie Chagoury School of Medicine by Author "Vandecasteele, Grégoire"

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Browsing Gilbert and Rose-Marie Chagoury School of Medicine by Author "Vandecasteele, Grégoire"

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  • Cardiac phosphodiesterases are differentially increased in diabetic cardiomyopathy 
    Hanna, Rita; Nour-Eldine, Wared; Saliba, Youakim; Dagher-Hamalian, Carole; Hachem, Pia; Abou-Khalil, Pamela; Mika, Delphine; Varin, Audrey; El Hayek, Magali Samia; Pereira, Laëtitia; Fares, Nassim; Vandecasteele, Grégoire; Abi-Gerges, Aniella (2021-12-23)
    Aim Diabetic cardiomyopathy (DCM) accomodates a spectrum of cardiac abnormalities. This study aims to investigate whether DCM is associated with changes in cyclic adenosine 3′-5′ monophosphate (cAMP) signaling, particularly ...
  • Compartmentation of Cyclic Nucleotide Signaling in the Heart 
    Fischmeister, Rodolphe; Castro, Liliana R.V.; Abi-Gerges, Aniella; Rochais, Francesca; Jurevicius, Jonas; Leroy, Jerome; Vandecasteele, Grégoire (2017-10-19)
    A current challenge in cellular signaling is to decipher the complex intracellular spatiotemporal organization that any given cell type has developed to discriminate among different external stimuli acting via a common ...
  • Differential changes in cyclic adenosine 3′-5′ monophosphate (cAMP) effectors and major Ca2+ handling proteins during diabetic cardiomyopathy 
    Chaoul, Victoria; Hanna, Rita; Hachem, Pia; El Hayek, Magali Samia; Nour-Eldine, Wared; Abou-Khalil, Pamela; Abi-Ramia, Elias; Vandecasteele, Grégoire; Abi-Gerges, Aniella (2023-04-04)
    Diabetic cardiomyopathy (DCM) is associated with differential and time-specific regulation of β-adrenergic receptors and cardiac cyclic nucleotide phosphodiesterases with consequences for total cyclic adenosine 3′-5′ ...
  • Phosphodiesterase 4B in the cardiac L-type Ca2+ channel complex regulates Ca2+ current and protects against ventricular arrhythmias in mice 
    Leroy, Jerome; Richter, Wito; Mika, Delphine; Castro, Liliana.R. V.; Abi-Gerges, Aniella; Xie, Moses; Scheitrum, Colleen; Lefebvre, Florence; Schittl, Julia; Vandecasteele, Grégoire (2017-10-19)
    β-Adrenergic receptors (β-ARs) enhance cardiac contractility by increasing cAMP levels and activating PKA. PKA increases Ca2+-induced Ca2+ release via phosphorylation of L-type Ca2+ channels (LTCCs) and ryanodine receptor ...

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