Browsing Gilbert and Rose-Marie Chagoury School of Medicine by Author "Sayre, L.M."

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Development of fluorinated 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogs with potent nigrostriatal toxicity for potential use in positron emission tomography studies

Riachi, N.J.; Harik, S.I.; Hritz, M.A.; Berridge, M.S.; Sayre, L.M. (2019-04-15)

The discovery of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) toxicity stimulated intense interest in neurotoxicology and in the possible toxic etiology of Parkinson's disease. Better understanding of MPTP neurotoxicity ...
On the mechanisms underlying 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity. II. Susceptibility among mammalian species correlates with the toxin's metabolic patterns in brain microvessels and liver

Riachi, N.J.; Harik, S.I.; Kalaria, R.N.; Sayre, L.M. (2019-04-15)

Systemic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) causes parkinsonism in humans and other primates, but not in rats; mice are intermediate in their susceptibility which varies among strains. We hypothesized ...

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