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Browsing Gilbert and Rose-Marie Chagoury School of Medicine by Author "Curley, Steven"

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Browsing Gilbert and Rose-Marie Chagoury School of Medicine by Author "Curley, Steven"

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  • Activation of Src Kinase in Primary Colorectal Carcinoma 
    Abdalla, Eddie; Allgayer, Heike; Boyd, Douglas; Heiss, Markus; Curley, Steven; Gallick, Gary (2015-11-10)
    BACKGROUND. The specific activity of the non-receptor protein tyrosine kinase, Src, is increased in the majority of colon and rectal adenocarcinomas compared to normal mucosa. However, the prognostic significance of this ...
  • Association between hypothyroidism and hepatocellular carcinoma 
    Hassan, Manal; Kaseb, Ahmed; Li, Donghui; Vauthey, Jean-Nicolas; Thomas, Melanie; Curley, Steven; Spitz, Margaret; Sherman, Steven; Abdalla, Eddie; Davila, Marta; Lozano, Richard; Hassan, Deena; Wenyaw, Chan; Brown, Thomas; Abbruzzese, James; Patt, Yehuda (2015-11-17)
    Thyroid hormones play an essential role in lipid mobilization, lipid degradation, and fatty acid oxidation. Hypothyroidism has been associated with nonalcoholic steatohepatitis; however, the association between thyroid ...
  • Association of Computed Tomography Morphologic Criteria With Pathologic Response and Survival in Patients Treated With Bevacizumab for Colorectal Liver Metastases 
    Shin Chun, Yun; Vauthey, Jean-Nicolas; Boonsirikamcha, Piyaporn; Maru, Dipen; Kopetz, Scott; Palavecino, Martin; Curley, Steven; Abdalla, Eddie; Kaur, Harmeet; Charnsangavej, Chusilp; Loyer, Evelyne (2015-11-17)
    Context The standard criteria used to evaluate tumor response, the Response Evaluation Criteria in Solid Tumors (RECIST), were developed to assess tumor shrinkage after cytotoxic chemotherapy and may be limited in assessing ...
  • Association of Diabetes Duration and Diabetes Treatment with the Risk of Hepatocellular Carcinoma 
    Hassan, Manal; Curley, Steven; Li, Donghui; Kaseb, Ahmed (2015-11-19)
    BACKGROUND: Despite the observed association between diabetes mellitus and hepatocellular carcinoma (HCC), little is known about the effect of diabetes duration before HCC diagnosis and whether some diabetes medications reduced ...
  • Bevacizumab Improves Pathologic Response and Protects Against Hepatic Injury in Patients Treated With Oxaliplatin-Based Chemotherapy for Colorectal Liver Metastases 
    Ribero, David; Wang, Huamin; Donadon, Matteo; Zorzi, Daria; Thomas, Melanie; Eng, Cathy; Chang, David; Curley, Steven; Abdalla, Eddie; Ellis, Lee; Vauthey, Nicolas (2015-11-16)
    BACKGROUND. The current study evaluated the effect of bevacizumab added to fluoropyrimidine-plus-oxaliplatin (5FU/OX) chemotherapy for colorectal liver metastases (CLM) on the pathologic response and nontumorous liver ...
  • Chemotherapy Regimen Predicts Steatohepatitis and an Increase in 90-Day Mortality After Surgery for Hepatic Colorectal Metastases 
    Vauthey, Nicolas; Pawlik, Timothy; Ribero, Dario; Wu, Tsung-Teh; Zorzi, Daria; Hoff, Paulo; Xiong, Henry; Eng, Cathy; Lauwers, Gregory; Mino-Kenudson, Mari; Risio, Mauro; Muratore, Andrea; Capussotti, Lorenzo; Curley, Steven; Abdalla, Eddie (2015-11-12)
    Purpose Chemotherapy before resection of hepatic colorectal metastases (CRM) may cause hepatic injury and affect postoperative outcome. Patients and Methods Four hundred six patients underwent hepatic resection of CRM ...
  • Comparison between hepatic wedge resection and anatomic resection for colorectal liver metastases 
    Abdalla, Eddie; Zorzi, Daria; Mullen, John; Pawlik, Timothy; Andres, Axel; Muratore, Andrea; Curley, Steven; Mentha, Gilles; Capussotti, Lorenzo; Vauthey, Nicolas (2015-11-12)
    Some investigators have suggested that wedge resection (WR) confers a higher incidence of positive margins and an inferior survival compared with anatomic resection (AR) of colorectal liver metastases (CLM). We sought to ...
  • Comparison of CT Methods for Determining the Fat Content of the Liver 
    Kodama, Yoshihisa; Ng, Chaan; Wu, Tsung-T; Ayers, Gregory; Curley, Steven; Abdalla, Eddie; Vauthey, Nicolas; Chamsangavej, Chulsip (2015-11-16)
    OBJECTIVE. The purpose of this study was to assess which of a number of methods of measuring attenuation on CT scans is best for prediction of hepatic fat content. MATERIALS AND METHODS. This retrospective study was ...
  • Critical Appraisal of the Clinical and Pathologic Predictors of Survival After Resection of Large Hepatocellular Carcinoma 
    Abdalla, Eddie; Pawlik, Timothy; Poon, Ronnie; Zorzi, Daria; Ikai, Iwao; Curley, Steven; Nagorney, David; Belghiti, Jacques; Oi-Lin Ng, Irene; Yamaoka, Yoshio; Lauwers, Gregory; Vauthey, Nicolas (2015-11-11)
    Hypothesis A subset of patients with hepatocellular carcinoma (HCC) with a diameter of 10 cm or larger may benefit from hepatic resection. Design Retrospective study of a multi-institutional database. Setting Five ...
  • Cytosolic Phospholipase A2-Mediated ICAM-1 Expression Is Calcium Dependent 
    Abdalla, Eddie; Carlton, Barnett; Moore, Ernest; Silliman, Christopher; David, Patrick; Curley, Steven (2015-11-10)
    Background. Some human malignancies such as virus-related hepatocellular cancer arise in a setting of chronic inflammation. Upregulation of ICAM-1 is a seminal late event in malignant transformation following chronic ...
  • Debunking dogma 
    Abdalla, Eddie; Pawlik, Timothy; Vauthey, Nicolas; Curley, Steven (2015-11-12)
    Treatment of four or more colorectal liver metastases (CRLMs) is controversial and remains a relative contraindication to surgery at some institutions. We sought to assess the outcome of patients with four or more CRLMs ...
  • Early and Late Complications After Radiofrequency Ablation of Malignant Liver Tumors in 608 Patients 
    Curley, Steven; Marra, Paolo; Beaty, Karen; Vauthey, Nicolas; Abdalla, Eddie; Scaife, Courtney; Raut, Chan; Wolff, Robert; Choi, Haesun; Loyer, Evelyne; Vallone, Paolo; Fiore, Francesco; Scordino, Fabrizio; Di Rosa, Vincenzo; Orlando, Raffaele; Pignata, Sandro; Daniele, Bruno; Izzo, Francesco (2015-11-10)
    Background: Radiofrequency ablation (RFA) has become a common treatment of patients with unresectable primary and secondary hepatic malignancies. We performed this prospective analysis to determine early (within 30 days) ...
  • Effect of different types of smoking and synergism with hepatitis C virus on risk of hepatocellular carcinoma in American men and women 
    Hassan, Manal; Spitz, Margaret; Thomas, Melanie; El-Deeb, Adel; Glover, Katrina; Nguyem, Nga; Chan, Wenyaw; Kaseb, Ahmed; Curley, Steven; Vauthey, Nicolas; Ellis, Lee; Abdalla, Eddie; Lozano, Richard; Patt, Yehuda; Brown, Thomas; Abbruzzese, James; Li, Donghui (2015-11-17)
    The International Agency for Research on Cancer has declared smoking to be a risk factor for hepatocellular carcinoma (HCC). However, passive exposure to cigarette smoke and use of noncigarette tobacco products on the risk ...
  • Effect of Surgical Margin Status on Survival and Site of Recurrence After Hepatic Resection for Colorectal Metastases 
    Pawlik, Timothy; Scoggins, Charles; Zorzi, Daria; Abdalla, Eddie; Andres, Axel; Eng, Cathy; Curley, Steven; Loyer, Evelyne; Muratore, Andrea; Mentha, Gilles; Capussotti, Lorenzo; Vauthey, Nicolas (2015-11-11)
    Objective: To evaluate the influence of surgical margin status on survival and site of recurrence in patients treated with hepatic resection for colorectal metastases. Methods: Using a multicenter database, 557 ...
  • Effectiveness of Positron Emission Tomography for Predicting Chemotherapy Response in Colorectal Cancer Liver Metastases 
    Glazer, Evan; Beaty, Karen; Abdalla, Eddie; Vauthey, Jean-Nicolas; Curley, Steven (2015-11-19)
    Hypothesis Chemotherapeutic agents may be able to convert unresectable colorectal hepatic metastasis to resectable disease, therefore changing the surgical options. The role of positron emission tomography (PET) for ...
  • Extended hepatectomy in patients with hepatobiliary malignancies with and without preoperative portal vein embolization 
    Abdalla, Eddie; Barnett, Carlton; Doherty, Dorota; Curley, Steven; Vauthey, Nicolas (2015-11-10)
    Hypothesis Preoperative portal vein embolization (PVE) allows potentially curative hepatic resection without additional morbidity or mortality in patients with hepatobiliary malignancies who are marginal candidates for ...
  • Extended Preoperative Chemotherapy Does Not Improve Pathologic Response and Increases Postoperative Liver Insufficiency After Hepatic Resection for Colorectal Liver Metastases 
    Kishi, Yoji; Zorzi, Daria; Contreras, Carlo; Maru, Dipen; Kopetz, Scott; Ribero, Dario; Motta, Manuela; Ravarino, Nicoletta; Risio, Mauro; Curley, Steven; Abdalla, Eddie; Capussotti, Lorenzo; Vauthey, Jean-Nicolas (2015-11-19)
    Background The optimal duration, safety, and benefit of preoperative chemotherapy in patients with colorectal liver metastases (CLM) are unclear. We evaluated the association between the duration of preoperative chemotherapy ...
  • Extrahepatic Bile Duct Adenocarcinoma 
    Borghero, Yerko; Crane, Christopher; Szklaruk, Janio; Oyarzo, Mauricio; Curley, Steven; Pisters, Peter; Evans, Douglas; Abdalla, Eddie; Thomas, Melanie; Das, Prajnan; Wistuba, Ignacio; Krishnan, Sunil; Vauthey, Nicolas (2015-11-16)
    Background Patients with resected extrahepatic bile duct adenocarcinoma who have microscopically positive resection margins and/or pathologic locoregional nodal involvement (R1pN1) have a high-risk of locoregional recurrence, ...
  • Hepatic Insufficiency and Mortality in 1,059 Noncirrhotic Patients Undergoing Major Hepatectomy 
    Mullen, John; Ribero, Dario; Reddy, Srinevas; Donadon, Matteo; Zorzi, Daria; Gautam, Shiva; Abdalla, Eddie; Curley, Steven; Capussotti, Lorenzo; Clary, Bryan; Vauthey, Nicolas (2015-11-16)
    Background To establish a reliable definition of postoperative hepatic insufficiency (PHI) in noncirrhotic patients undergoing major hepatectomy. No standard definition of PHI has been established, but one is essential ...
  • Hepatic Resection for Metastatic Melanoma 
    Abdalla, Eddie; Pawlik, Timothy; Zorzi, Daria; Clary, Bryan; Gershenwald, Jeffrey; Ross, Merrick; Aloia, Thomas; Curley, Steven; Camacho, Luis; Capussotti, Lorenzo; Elias, Dominique; Vauthey, Nicolas (2015-11-12)
    Background Resection of melanoma metastatic to the liver remains controversial. We evaluated the efficacy of hepatic resection in patients with metastatic ocular and cutaneous melanoma and assessed factors that could ...

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