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Browsing Gilbert and Rose-Marie Chagoury School of Medicine by Author "Abi-Gerges, Aniella"

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Browsing Gilbert and Rose-Marie Chagoury School of Medicine by Author "Abi-Gerges, Aniella"

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  • Hanna, Rita; Nour-Eldine, Wared; Saliba, Youakim; Dagher-Hamalian, Carole; Hachem, Pia; Abou-Khalil, Pamela; Mika, Delphine; Varin, Audrey; El Hayek, Magali Samia; Pereira, Laëtitia; Fares, Nassim; Vandecasteele, Grégoire; Abi-Gerges, Aniella (2021-12-23)
    Aim Diabetic cardiomyopathy (DCM) accomodates a spectrum of cardiac abnormalities. This study aims to investigate whether DCM is associated with changes in cyclic adenosine 3′-5′ monophosphate (cAMP) signaling, particularly ...
  • Fischmeister, Rodolphe; Castro, Liliana R.V.; Abi-Gerges, Aniella; Rochais, Francesca; Jurevicius, Jonas; Leroy, Jerome; Vandecasteele, Grégoire (2017-10-19)
    A current challenge in cellular signaling is to decipher the complex intracellular spatiotemporal organization that any given cell type has developed to discriminate among different external stimuli acting via a common ...
  • Abi-Gerges, Aniella; Richter, Wito; Lefebvre, Florence; Mateo, Philippe; Varin, Audrey; Heymes, Chrisrophe; Samuel, Jane-Lise; Lugnier, Claire; Conti, Marco; Fischmeister, Rodolphe; Vandecasteele, Gregoire (2017-10-19)
    Rationale: Multiple cyclic nucleotide phosphodiesterases (PDEs) degrade cAMP in cardiomyocytes but the role of PDEs in controlling cAMP signaling during pathological cardiac hypertrophy is poorly defined. Objective: ...
  • Abi-Gerges, Aniella; Dagher-Hamalian, Carole; Abou-Khalil, Pamela; Chahine, Joe Braham; Hachem, Pia; Khalil, Christian (2020-09-15)
    Waterpipe smoking is a popular pastime worldwide with statistics pointing to an alarming increase in consumption. In the current paper, the evaluation of sub-chronic waterpipe smoke exposure was undertaken using C57BL/6 ...
  • MRP4 
    Abi-Gerges, Aniella; Sassi, Yassine; Mougenot, Nathalie; Jacquet, Adeline; Engelhardt, Stefan; Hatem, Stephanie N.; Hulot, Jean-Sebastien; Lompre, Anne-Marie (2017-10-19)
    Rationale: Transporters of the ABCC family, called MRP4 and MRP5, have been described to control cAMP homeostasis by extruding it from various cell types. Objective: The aim of our study was to determine the role of ...
  • Leroy, Jerome; Richter, Wito; Mika, Delphine; Castro, Liliana.R. V.; Abi-Gerges, Aniella; Xie, Moses; Scheitrum, Colleen; Lefebvre, Florence; Schittl, Julia; Vandecasteele, Grégoire (2017-10-19)
    β-Adrenergic receptors (β-ARs) enhance cardiac contractility by increasing cAMP levels and activating PKA. PKA increases Ca2+-induced Ca2+ release via phosphorylation of L-type Ca2+ channels (LTCCs) and ryanodine receptor ...
  • Sassi, Yassine; Abi-Gerges, Aniella; Fauconnier, Jeremy; Mougenot, Nathalie; Reiken, Steven; Haghighi, Kobra; Kranias, Evangelia G.; Marks, Andrew R.; Hulot, Jean‐Sébastien (2017-10-19)
    Recent studies indicate that members of the multidrug-resistance protein (MRP) family belonging to ATP binding cassette type C (ABCC) membrane proteins extrude cyclic nucleotides from various cell types. This study aimed ...
  • Leroy, Jerome; Abi-Gerges, Aniella; Richter, Wito; Nikolaev, Viacheslav O.; Engelhardt, Stefan; Lohse, Martin J.; Conti, Marco; Fischmeister, Rodolphe; Vandecasteele, Gregoire (2017-10-19)
    β-Adrenergic stimulation increases cAMP in cardiac cells to induce PKA-mediated phosphorylation of various proteins regulating heart function, such as the L-type Ca 2+ channels which carry I Ca,L and trigger cardiac ...
  • Abi-Gerges, Aniella; Castro, Liliana; Leroy, Jerome; Domergue, Valerie; Fischmeister, Rodolphe; Vandecasteele, Gregoire (2020-11-10)
    Background In cardiomyocytes, phosphodiesterases (PDEs) type 3 and 4 are the predominant enzymes that degrade cAMP generated by β-adrenergic receptors (β-ARs), impacting notably the regulation of the L-type Ca2+ current ...
  • Leroy, Jerome; Abi-Gerges, Aniella; Nikolaev, Viacheslav O.; Richter, Wito; Lecheme, Patrick; Mazet, Jean-Luc; Conti, Marco; Fischmeister, Rodolphe; Vandecasteele, Gregoire (2017-10-19)
    Steady-state activation of cardiac β-adrenergic receptors leads to an intracellular compartmentation of cAMP resulting from localized cyclic nucleotide phosphodiesterase (PDE) activity. To evaluate the time course of the ...
  • Fischmeister, Rodolphe; Castro, Liliana; Abi-Gerges, Aniella; Rochais, Francesca; Vandecasteele, Gregoire (2017-10-19)
    Biochemical studies have established the presence of a NO pathway in the heart, including sources of NO and various effectors. Several cardiac ion channels have been shown to be modified by NO, such as L-type Ca2+, ...
  • Rochais, Francesca; Abi-Gerges, Aniella; Homer, Kathleen; Lefebvre, Florence; Cooper, Dermot M.F.; Conti, Marco; Fischmeister, Rodolphe; Vandecasteele, Gregoire (2017-10-19)
    Compartmentation of cAMP is thought to generate the specificity of Gs-coupled receptor action in cardiac myocytes, with phosphodiesterases (PDEs) playing a major role in this process by preventing cAMP diffusion. We tested ...
  • Abi-Gerges, Aniella; Fischmeister, Rodolphe; Vandecasteele, Gregoire (2018-12-19)
    The second messenger cAMP is the most important modulator of sympathetic control over cardiac contractility. Recent studies have documented the existence of local pools of cAMP in cardiac cells (Jurevicius & Fischmeister ...

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