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Browsing Gilbert and Rose-Marie Chagoury School of Medicine by Title

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Browsing Gilbert and Rose-Marie Chagoury School of Medicine by Title

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  • Curing hepatocellular carcinomatosis with biologic therapy and surgery 
    Thomas, Melanie; Tetzlaff, Eric; Lozano, Richard; Samp, Leigh; Butler, Charles; Gannon, Christopher; Hamilton, Stanley; Vauthey, Jean-Nicolas; Abdalla, Eddie (2015-11-17)
    Hepatocellular carcinoma (HCC) that present as hemoperitoneum are uncommon, often recur as peritoneal carcinomatosis, and have poor prognosis. Systemic chemotherapies are minimally effective in advanced HCC and less so as ...
  • Current and Emerging Therapies of Severe Epileptic Encephalopathies 
    Hani, Abeer J.; Mikati, Mohamad A. (2016-11-11)
    In this article, we review the treatment options for the pediatric epileptic encephalopathies and provide an update on the new and emerging therapies targeted at the underlying pathophysiology of many of these syndromes. ...
  • The current status of anatomy knowledge 
    Yammine, Kaissar (2019-06-27)
    Background: Gross anatomy is no longer considered a science, as it is no longer considered a research-led discipline. Looking to the current status of anatomical teaching, there is worldwide unanimity regarding the steady ...
  • Cutaneous vascular disorders associated with internal malignancy 
    Tannous, Zeina; Doukas, Apostolos G.; Sakamoto, Fernanda H.; Farinelli, William A.; Smith, Nicholas A.; Zurakowski, David; Anderson, Rox R. (2017-11-10)
    This article provides a detailed review of the vascular manifestations affecting the skin in relationship to internal malignancies. Vascular abnormalities heralding internal malignancies can be divided into three main ...
  • Cyclic nucleotide phosphodiesterases in health and disease 
    Beavo, Joseph A.; Francis, Sharron H.; Houslay, Miles D. (CRC Press, 2018-12-18)
  • Cyclosporine lymphocyte maximum level 
    Kilani, Halal E.; Karam, Albert S.; Masri, Marwan A.; Stephan, Antoine G.; Mourad, Nina; El Ghoul, Bassam (2019-04-09)
    Objectives: To determine the relationship between clinical outcome, lymphocyte count (LC), and cyclosporine (CsA) lymphocyte maximum level (LTmL) in kidney transplant recipients. Materials and Methods: CsA LTmL was ...
  • Cyclosporine Lymphocyte Versus Whole Blood Pharmacokinetic Monitoring 
    Mokhbat, J.; Kilani, H.; Barbari, A.; Masri, M. A.; Stephan, A.; Rizk, S.; Kamel, G.; Joubran, N. (2017-02-27)
    Cyclosporine (CyA) blood trough level (BTL), CyA dose pharmacokinetics, area under the curve (AUC), blood Cyclophylin (CyP) binding, and exposure index (EI) are often used as indicators of CyA efficacy and dose adjustment,1; ...
  • Cytosolic Phospholipase A2-Mediated ICAM-1 Expression Is Calcium Dependent 
    Abdalla, Eddie; Carlton, Barnett; Moore, Ernest; Silliman, Christopher; David, Patrick; Curley, Steven (2015-11-10)
    Background. Some human malignancies such as virus-related hepatocellular cancer arise in a setting of chronic inflammation. Upregulation of ICAM-1 is a seminal late event in malignant transformation following chronic ...
  • The DD genotype of the ACE gene polymorphism is associated with diabetic nephropathy in type-1 diabetics 
    Azar, Sami T.; Zalloua, Pierre A.; Medlej, Rita; Halabi, George (2019-07-19)
    Genetic factors are involved in the development of diabetic nephropathy in type-1 diabetes. We are examining the association of the angiotensin-converting enzyme (ACE), insertion/deletion (I/D) polymorphism with the presence ...
  • Debunking dogma 
    Abdalla, Eddie; Pawlik, Timothy; Vauthey, Nicolas; Curley, Steven (2015-11-12)
    Treatment of four or more colorectal liver metastases (CRLMs) is controversial and remains a relative contraindication to surgery at some institutions. We sought to assess the outcome of patients with four or more CRLMs ...
  • Decreased Expression and Activity of cAMP Phosphodiesterases in Cardiac Hypertrophy and Its Impact on β-Adrenergic cAMP Signals 
    Abi-Gerges, Aniella; Richter, Wito; Lefebvre, Florence; Mateo, Philippe; Varin, Audrey; Heymes, Chrisrophe; Samuel, Jane-Lise; Lugnier, Claire; Conti, Marco; Fischmeister, Rodolphe; Vandecasteele, Gregoire (2017-10-19)
    Rationale: Multiple cyclic nucleotide phosphodiesterases (PDEs) degrade cAMP in cardiomyocytes but the role of PDEs in controlling cAMP signaling during pathological cardiac hypertrophy is poorly defined. Objective: ...
  • Decreased phosphodiesterase activities in cardiac hypertrophy 
    Abi-Gerges, A.; Castro, L.R.V.; Leroy, J.; Heymes, C.; Samuel, J.-L.; Lugnier, C.; Fischmeister, R.; Vandecasteele, G. (2018-12-18)
    There is limited information on the changes in cardiac cyclic nucleotide phosphodiesterases (PDE1 to PDE5) during hypertrophy and the functional consequences on the cAMP pathway. To address this, 3-week-old rats were ...
  • Deep Sedation in Advanced Endoscopy 
    Azar, Riad R.; Cote, Gregory A.; Hovis, Robert M.; Ansstas, Michael; Waldbaum, Lawrence; Edmundowicz, Steven A.; Mullady, Daniel; Jonnalagadda, Sreenivasa S. (2016-09-27)
    Background: When administered by a trained professional, the safety and efficacy of propofol in advanced endoscopy is well described. While use of propofol requires advanced airway training, it is unclear how frequently ...
  • Defined Clinical Classifications Are Associated with Outcome of Patients with Anatomically Resectable Pancreatic Adenocarcinoma Treated with Neoadjuvant Therapy 
    Tzeng, Ching-Wei; Fleming, Jason; Lee, Jeffrey; Xiao, Lianchun; Pisters, Peter; Vauthey, Jean-Nicolas; Abdalla, Eddie; Wolff, Robert; Varadhachary, Gauri; Fogelman, David; Crane, Christopher; Balachandran, Aparna; Katz, Matthew (2015-11-20)
    Background We previously introduced a classification system for patients with localized pancreatic adenocarcinoma that integrates assessments of tumor anatomy, cancer biology, and patient physiology. By means of this ...
  • Degrees of Uncertainty—“Statistically Insignificant” 
    Hubayter, ZR; Muasher, SJ (2017-09-05)
  • Delayed Recovery after Pancreaticoduodenectomy 
    Abdalla, Eddie; Aloia, Thomas; Lee, Jeffrey; Vauthey, Nicolas; Wolff, Robert; Varadhachary, Gauri; Abbruzzese, James; Crane, Christopher; Evans, Douglas; Pisters, Peter (2015-11-12)
    Background Delayed recovery after pancreaticoduodenectomy (PD) is believed to preclude adjuvant therapy for approximately 30% of patients who undergo elective PD as initial treatment for pancreatic adenocarcinoma. This ...
  • Delineating melanoma using multimodal polarized light imaging 
    Tannous, Zeina; Al-Arashi, Munir; Shah, Sonali; Yaroslavsky, Anan N. (2017-11-10)
    Background and Significance Melanoma accounts for 3% of all skin cancers but causes 83% of skin cancer deaths. The first step in treatment of melanoma is the removal of the lesions, usually by surgical excision. Currently ...
  • Demographic and obstetric factors influencing pregnancy outcome in twin gestations 
    Khoury, Alfred; Tarter, Jennifer; Barton, John R.; Sibai, Baha M. (2019-04-16)
    Objective: Our purpose was to identify the influence of parity and previous preterm delivery on pregnancy outcome in twin gestations. Study Design: A retrospective comparative analysis of women with twin gestations completing ...
  • Deontologie, ethique et sida 
    Mokhbat, Jacques; Daher, Michael; Tohme, Souheil (2017-02-28)
  • Dermal melanocytic proliferation with features of a plaque-type blue nevus and neurocristic hamartoma 
    Tannous, Zeina; Bevona, Caroline; Tsao, Hensin (2017-11-08)
    Blue nevi (BN) and neurocristic hamartomas (NCH) are pigmented lesions that originate from the aberrant development of cells derived from the neural crest. BN are composed of dermal melanocytes, whereas NCH have a broader ...

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