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Browsing Gilbert and Rose-Marie Chagoury School of Medicine by Issue Date

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Browsing Gilbert and Rose-Marie Chagoury School of Medicine by Issue Date

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  • Biallelic inactivation of the APC gene is associated with hepatocellular carcinoma in familial adenomatous polyposis coli 
    Abdalla, Eddie; Su, Li-Kuo; Law, Calvin; Kohlmann, Wendy; Rashid, Asif; Vauthey, Nicolas (2015-11-10)
    BACKGROUND Certain primary hepatic tumors have been associated with familial adenomatous polyposis (FAP), a condition caused by germline mutations of the adenomatous polyposis coli (APC) gene. However, a genetic association ...
  • Early and Late Complications After Radiofrequency Ablation of Malignant Liver Tumors in 608 Patients 
    Curley, Steven; Marra, Paolo; Beaty, Karen; Vauthey, Nicolas; Abdalla, Eddie; Scaife, Courtney; Raut, Chan; Wolff, Robert; Choi, Haesun; Loyer, Evelyne; Vallone, Paolo; Fiore, Francesco; Scordino, Fabrizio; Di Rosa, Vincenzo; Orlando, Raffaele; Pignata, Sandro; Daniele, Bruno; Izzo, Francesco (2015-11-10)
    Background: Radiofrequency ablation (RFA) has become a common treatment of patients with unresectable primary and secondary hepatic malignancies. We performed this prospective analysis to determine early (within 30 days) ...
  • Obesity and diabetes as a risk factor for hepatocellular carcinoma 
    Abdalla, Eddie; Regimbeau, Jean-Marc; Colombat, Magali; Mognol, Philippe; Degott, Claude; Degos, Francoise; Farges, Olivier; Belghiti, Jacques (2015-11-10)
    Ten percent of patients who undergo resection for hepatocellular carcinoma (HCC) associated with chronic liver disease have no detectable cause for this underlying liver disease. Recent studies have shown that patients ...
  • Portal vein embolization 
    Abdalla, Eddie; Hicks, M.E.; Vauthey, Nicolas (2015-11-10)
    Background: Advances in surgery have reduced the mortality rate after major liver resection, but complications resulting from inadequate postresection hepatic size and function remain. Portal vein embolization (PVE) was ...
  • Total and segmental liver volume variations 
    Abdalla, Eddie; Denys, Alban; Chevalier, Patrick; Nemr, Rabih; Vauthey, Nicolas (2015-11-10)
    Background Liver remnant volumes after major hepatic resection and graft volumes for liver transplantation correlate with surgical outcome. The relative contributions of the hepatic segments to total liver volume (TLV) ...
  • The small remnant liver after major liver resection 
    Yigitler, Cengizhan; Farges, Olivier; Kianmanesh, Reza; Regimbeau, Jean-Marc; Abdalla, Eddie; Belghiti, Jacques (2015-11-10)
    The maximum extent of hepatic resection compatible with a safe postoperative outcome is unknown. The study goal was to determine the incidence and impact of a small remnant liver volume after major liver resection in ...
  • Surgical treatment of colorectal cancer metastasis 
    Abdalla, Eddie; Izzo, Francesco; Curley, Steven; Vauthey, Nicolas (2015-11-10)
    Colorectal cancer is one of the most common solid tumors affecting people around the world. A significant proportion of patients with colorectal cancer will develop or will present with liver metastases. In some of these ...
  • Portal vein embolization in preparation for major hepatic resection 
    Madoff, David; Abdalla, Eddie; Vauthey, Nicolas (2015-11-11)
    Portal vein (PV) embolization (PVE) is gaining acceptance in the preoperative management of patients selected for major hepatic resection. PVE redirects portal blood flow to the intended liver remnant to induce hypertrophy ...
  • Critical Appraisal of the Clinical and Pathologic Predictors of Survival After Resection of Large Hepatocellular Carcinoma 
    Abdalla, Eddie; Pawlik, Timothy; Poon, Ronnie; Zorzi, Daria; Ikai, Iwao; Curley, Steven; Nagorney, David; Belghiti, Jacques; Oi-Lin Ng, Irene; Yamaoka, Yoshio; Lauwers, Gregory; Vauthey, Nicolas (2015-11-11)
    Hypothesis A subset of patients with hepatocellular carcinoma (HCC) with a diameter of 10 cm or larger may benefit from hepatic resection. Design Retrospective study of a multi-institutional database. Setting Five ...
  • Pancreaticoduodenectomy with vascular resection 
    Abdalla, Eddie; Tseng, Jennifer; Raut, Chandrajit; Lee, Jeffrey; Pisters, Peter; Vauthey, Nicolas; Gomez, Henry; Sun, Charlotte; Crane, Christopher; Wolff, Robert; Evans, Douglas (2015-11-11)
    Major vascular resection performed at the time of pancreaticoduodenectomy (PD) for adenocarcinoma remains controversial. We analyzed all patients who underwent vascular resection (VR) at the time of PD for any histology ...
  • Staging classifications for hepatocellular carcinoma 
    Van Deusen, Mathew; Abdalla, Eddie; Vauthey, Nicolas (2015-11-11)
    Evaluation and treatment of patients with hepatocellular carcinoma is dependent on accurate staging. Tumor-specific factors and the degree of underlying liver disease must be considered when evaluating patients with ...
  • Transhepatic Ipsilateral Right Portal Vein Embolization Extended to Segment IV 
    Madoff, David; Abdalla, Eddie; Gupta, Sanjay; Morris, Jeffrey; Denys, Alban; Wallace, Micheal; Morello, Frank; Ahrar, Kamran; Murthy, Ravi; Hicks, Marshall; Vauthey, Nicolas (2015-11-11)
    PURPOSE To analyze outcomes after right portal vein embolization extended to segment IV (right PVE + IV) before extended right hepatectomy, including liver hypertrophy, resection rates, and complications after embolization ...
  • Effect of Surgical Margin Status on Survival and Site of Recurrence After Hepatic Resection for Colorectal Metastases 
    Pawlik, Timothy; Scoggins, Charles; Zorzi, Daria; Abdalla, Eddie; Andres, Axel; Eng, Cathy; Curley, Steven; Loyer, Evelyne; Muratore, Andrea; Mentha, Gilles; Capussotti, Lorenzo; Vauthey, Nicolas (2015-11-11)
    Objective: To evaluate the influence of surgical margin status on survival and site of recurrence in patients treated with hepatic resection for colorectal metastases. Methods: Using a multicenter database, 557 ...
  • Tumor size predicts vascular invasion and histologic grade 
    Abdalla, Eddie; Pawlik, Timothy; Delman, Keith; Vauthey, Nicolas; Nagorney, David; Oi-Lin Ng, Irene; Yamaoka, Yoshio; Ikai, Iwao; Belghiti, Jacques; Lauwers, Gregory; Poon, Ronnie (2015-11-11)
    Vascular invasion and high histologic grade predict poor outcome after surgical resection or liver transplantation for hepatocellular carcinoma (HCC). Despite the known association between tumor size and vascular invasion, ...
  • Two-Surgeon Technique for Hepatic Parenchymal Transection of the Noncirrhotic Liver Using Saline-Linked Cautery and Ultrasonic Dissection 
    Aloia, Thomas; Zorzi, Daria; Abdalla, Eddie; Vauthey, Nicolas (2015-11-11)
    Objective: The purpose of this study was to analyze our experience with saline-linked cautery in hepatic surgery. Summary Background Data: Safe and efficient hepatic parenchymal transection is predicated on the ...
  • Is extended hepatectomy for hepatobiliary malignancy justified? 
    Abdalla, Eddie; Vauthey, Nicolas; Pawlik, Timothy; Arens, James; Nemr, Rabih; Wei, Steven; Kennamer, Debra; Ellis, Lee; Curley, Steven (2015-11-11)
    Background: Extended hepatectomy may be required to provide the best chance for cure of hepatobiliary malignancies. However, the procedure may be associated with significant morbidity and mortality. Methods: We ...
  • Laparoscopy for diagnosis and staging of hepatobiliary malignancies 
    Abdalla, Eddie; Aloia, Thomas; Vauthey, Nicolas (2015-11-11)
    Objective: To review the role of diagnostic laparoscopy (DL) for staging of malignant diseases of the liver and biliary tract. Methodology: Critical review of the current literature. Results: Analysis of the utility ...
  • Operative considerations in resection of hilar cholangiocarcinoma 
    Abdalla, Eddie; Parikh, Alexandre; Vauthey, Nicolas (2015-11-11)
    This article reviews the preoperative evaluation and operative considerations in patients with hilar cholangiocarcinoma. The preoperative evaluation is based on the imaging evaluation of the longitudinal and radial extent ...
  • Portal Vein Embolization 
    Abdalla, Eddie; Madoff, David; Wallace, Micheal; Chaan, Ribero (2015-11-12)
    Portal vein embolization (PVE) has become an important tool in the preoperative management of select patients prior to major hepatic resection. PVE redirects portal flow to the intended remnant liver to induce hypertrophy ...
  • Chemotherapy Regimen Predicts Steatohepatitis and an Increase in 90-Day Mortality After Surgery for Hepatic Colorectal Metastases 
    Vauthey, Nicolas; Pawlik, Timothy; Ribero, Dario; Wu, Tsung-Teh; Zorzi, Daria; Hoff, Paulo; Xiong, Henry; Eng, Cathy; Lauwers, Gregory; Mino-Kenudson, Mari; Risio, Mauro; Muratore, Andrea; Capussotti, Lorenzo; Curley, Steven; Abdalla, Eddie (2015-11-12)
    Purpose Chemotherapy before resection of hepatic colorectal metastases (CRM) may cause hepatic injury and affect postoperative outcome. Patients and Methods Four hundred six patients underwent hepatic resection of CRM ...

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