• Selective changes in cytosolic β-adrenergic cAMP signals and L-type Calcium Channel regulation by Phosphodiesterases during cardiac hypertrophy 

  Abi-Gerges, Aniella; Castro, Liliana; Leroy, Jerome; Domergue, Valerie; Fischmeister, Rodolphe; Vandecasteele, Gregoire

  Background In cardiomyocytes, phosphodiesterases (PDEs) type 3 and 4 are the predominant enzymes that degrade cAMP generated by β-adrenergic receptors (β-ARs), impacting notably the regulation of the L-type Ca2+ current ...
• Evaluation of waterpipe smoke toxicity in C57BL/6 mice model 

  Abi-Gerges, Aniella; Dagher-Hamalian, Carole; Abou-Khalil, Pamela; Chahine, Joe Braham; Hachem, Pia; Khalil, Christian

  Waterpipe smoking is a popular pastime worldwide with statistics pointing to an alarming increase in consumption. In the current paper, the evaluation of sub-chronic waterpipe smoke exposure was undertaken using C57BL/6 ...
• Physicians’ empathy levels in a primary care setting 

  Al-Habbal, Khairat; Arawi, Thalia

  Background The physician–patient relationship is a crucial element in successful medical care. Empathy is the ability to understand an individual’s subjective experience yet remain as an observer. It plays a major role ...
• The use of household budget surveys to estimate the availability of fruits and vegetables for consumption in Swiss households after deduction of food waste 

  Bouclaous, Carmel; Jaubert, Ronald

  Background The consumption of 400-600 grams per day of fruits and vegetables has been linked to reduced risk of cardiovascular disease, and lower incidence of cancers and chronic diseases. This study explores the alignment ...
• Pyogenic spondylodiscitis 

  Skaf, G.S.; Domloj, N.T.; Fehlings, M.G.; Sabbagh, A.S.; Kanafani, Z.A.; Kanj, S.S.

  Although uncommon, spontaneous and postoperative pyogenic spondylodiscitis entail major morbidity and may be associated with serious long-term sequelae. A review of the literature was done to advance our understanding of ...
• Policy coherence for improved nutrition in Switzerland 

  Bouclaous, Carmel

  In Switzerland, the direct and indirect medical costs from non-communicable diseases are estimated at 51.7 billion Swiss francs per year. This essay describes the challenges faced by the Confederation in its efforts to ...
• Treatment of spontaneous and post-operative pyogenic spondylodiscitis 

  Skaff, Ghassan S.; Bouclaous, Carmel H.; Fehlings, Michael G.

  Spinal infection is an uncommon but important clinical problem that often requires aggressive medical and surgical management. If recognized early and treated appropriately, a full recovery can often be expected. Treatment ...
• Association between sources of sexuality education, sexual beliefs and behaviours in Lebanese young adults 

  Bouclaous, Carmel H.; Alrazim, Ayman; Chababi, James; Jamaleddine, Wassim; Nassar, Elma; Maalouf, Anthony; Aridy, Sara Dakour; Naccache, Mahmoud; Abboud, Donna Maria; Assi, Maria; Salka, Maysaa

  This study assessed the association between sources of sexuality education, sexual beliefs and behaviour among Lebanese youth. 451 unmarried students at a private university, mean age 20.25 (±1.41) years, participated in ...
• Prevalence of aggression in displaced syrian adolescents attending afternoon public schools in Beirut 

  Bouclasous, Carmel; El Safadi, Ali; Basbous, Mazen; Haddad, Iskander; Mahdi, Ahmad; Zibara, Victor; Ghazi, Rabih; Naamani, Karim; El Karaaoui, Jalal; Salameh, Rima

  We assessed aggression in displaced Syrian adolescents, aged 11 years and above, enrolled in Beirut's public schools during 2017–2018. Of 729 parental consent forms distributed in nine randomly selected schools, 368 (50.5%) ...
• Modification of glucocorticoid effects on body weight gain, plasma lipids by changes in diet composition 

  Bouclaous, Carmel; Torbay, Naji; Nassar, Camille; Baba, Nahla Hwalla

  The effects of macronutrient composition of the diet and glucocorticoid administration on weight gain, intestinal absorption and plasma lipids were investigated. Thirty seven male Wistar rats were divided into 4 groups, ...
• Clinical outcome of surgical treatment of failed back surgery syndrome 

  Skaf, Ghassan; Bouclaous, Carmel; Alaraj, Ali; Chamoun, Roukoz

  Background Failed back surgery syndrome (FBSS) is a condition in which there is failure to improve satisfactorily after back surgery. It is characterized by intractable pain and various degrees of functional disability ...
• Evaluation of prophylactic dosages of Enoxaparin in non-surgical elderly patients with renal impairment 

  Chamoun, Nibal; Ghanem, Hady; Hachem, Ahmad; Hariri, Essa; Lteif, Christelle; Mansour, Hanine; Dimassi, Hani; Zalloum, Richard; Ghanem, Geroges

  Background Thromboprophylaxis dosing strategies using enoxaparin in elderly patients with renal disease are limited, while dose adjustments or monitoring of anti-Xa levels are recommended. We sought to evaluate the efficacy ...
• Encyclopedia of biophysics 

  Roberts, Gordon; Watts, Anthony (Springer, )
• Implementing an interprofessional education programme in Lebanon 

  Farra, Anna; Zeenny, Rony; Nasser, Soumana; Asmar, Nadia; Milane, Aline; Bassil, Maya; Haidar, Mona; Habre, Maha; Zeeni, Nadine; Hoffart, Nancy

  Background: The Lebanese American University has a well-functioning inter-professional education (IPE) programme; this is a fundamental pedagogical approach in healthcare education in which students from different professions ...
• Branched-chain amino acids mediate resilience to chronic social defeat stress by activating BDNF/TRKB signaling 

  Nasrallah, Patrick; Abou Haidar, Edwina; Stephan, Joseph S.; El Hayek, Lauretta; Karnib, Nabil; Khalifeh, Mohamad; Barmo, Nour; Jabre, Vanessa; Houbeika, Rouba; Ghanem, Anthony; Nasser, Jason; Zeeni, Nadine; Bassil, Maya; F. Sleiman, Sama

  How individuals respond to chronic stress varies. Susceptible individuals ultimately develop depression; whereas resilient individuals live normally. In this study, our objective was to examine the effect of branched-chain ...
• The chemotherapeutic effect of β-2-himachalen-6-ol in chemically induced skin tumorigenesis 

  Daaboul, Hamid E.; Dagher, Carole; Taleb, Robin I.; Bodman-Smith, Kikki; Shebaby, Wassim N.; El-Sibai, Mirvat; Mroueh, Mohamad A.; Daher, Costantine F.

  β-2-himachalen-6-ol (HC), a novel sesquiterpene derived from Lebanese wild carrot, was shown to possess a remarkable anticancer activity. The present study investigates the in vitro anticancer activity of HC and its effect ...
• Diabetic ketoacidosis induced by single dose of pembrolizumab 

  Maamari, Julian; Yeung, Sai-Ching J.; Chaftari, Patrick S.

  Immune checkpoint inhibitors are a new class of anticancer drugs recently approved by the US Food and Drug Administration (FDA) for the treatment of various malignancies. Pembrolizumab is an immune checkpoint inhibitor ...
• Juvenile-onset diabetes and congenital cataract 

  Lenfant, Caroline; Baz, Patrick; Degavre, Anne; Phillippi, Anne; Senne, Valerie; Vandiedonck, Claire; Derbois, Celine; Nicolino, Marc; Zalloua, Pierre; Julier, Cecile

  Monogenic forms of diabetes may account for 1–5% of all cases of diabetes, and may occur in the context of syndromic presentations. We investigated the case of a girl affected by insulin-dependent diabetes, diagnosed at 6 ...
• WFS1 mutations are frequent monogenic causes of juvenile-onset diabetes mellitus in Lebanon 

  Zallloua, Pierre A.; Azar, Sami T.; Delepine, Marc; Makhoul, Nadine J.; Blanc, Herve; Sanyoura, May; Lavergne, Anne; Stankov, Karmen; Lemainque, Arnaud; Baz, Patrick; Julier, Cecile

  Most cases of juvenile-onset diabetes (JOD) are diagnosed as type 1 diabetes (T1D), for which genetic studies conducted in outbred Caucasian populations support the concept of multifactorial inheritance. However, this view ...
• Health system resilience 

  Ammar, Walid; Kdouh, Ola; Hammoud, Rawan; Hamadeh, Randa; Harb, Hilda; Ammar, Zeina; Atun, Rifat; Christiani, David; Zalloua, Pierre A.

  Background Between 2011 and 2013, the Lebanese population increased by 30% due to the influx of Syrian refugees. While a sudden increase of such magnitude represents a shock to the health system, threatening the continuity ...

View more