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Gilbert and Rose-Marie Chagoury School of Medicine

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Gilbert and Rose-Marie Chagoury School of Medicine

 

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  • Chamoun, Nibal; Ghanem, Hady; Hachem, Ahmad; Hariri, Essa; Lteif, Christelle; Mansour, Hanine; Dimassi, Hani; Zalloum, Richard; Ghanem, Georges
    Background Thromboprophylaxis dosing strategies using enoxaparin in elderly patients with renal disease are limited, while dose adjustments or monitoring of anti-Xa levels are recommended. We sought to evaluate the efficacy ...
  • Farra, Anna; Zeenny, Rony; Nasser, Soumana; Asmar, Nadia; Milane, Aline; Bassil, Maya; Haidar, Mona; Habre, Maha; Zeeni, Nadine; Hoffart, Nancy
    Background: The Lebanese American University has a well-functioning inter-professional education (IPE) programme; this is a fundamental pedagogical approach in healthcare education in which students from different professions ...
  • Nasrallah, Patrick; Abou Haidar, Edwina; Stephan, Joseph S.; El Hayek, Lauretta; Karnib, Nabil; Khalifeh, Mohamad; Barmo, Nour; Jabre, Vanessa; Houbeika, Rouba; Ghanem, Anthony; Nasser, Jason; Zeeni, Nadine; Bassil, Maya; F. Sleiman, Sama
    How individuals respond to chronic stress varies. Susceptible individuals ultimately develop depression; whereas resilient individuals live normally. In this study, our objective was to examine the effect of branched-chain ...
  • Daaboul, Hamid E.; Dagher, Carole; Taleb, Robin I.; Bodman-Smith, Kikki; Shebaby, Wassim N.; El-Sibai, Mirvat; Mroueh, Mohamad A.; Daher, Costantine F.
    β-2-himachalen-6-ol (HC), a novel sesquiterpene derived from Lebanese wild carrot, was shown to possess a remarkable anticancer activity. The present study investigates the in vitro anticancer activity of HC and its effect ...
  • Maamari, Julian; Yeung, Sai-Ching J.; Chaftari, Patrick S.
    Immune checkpoint inhibitors are a new class of anticancer drugs recently approved by the US Food and Drug Administration (FDA) for the treatment of various malignancies. Pembrolizumab is an immune checkpoint inhibitor ...
  • Lenfant, Caroline; Baz, Patrick; Degavre, Anne; Phillippi, Anne; Senne, Valerie; Vandiedonck, Claire; Derbois, Celine; Nicolino, Marc; Zalloua, Pierre; Julier, Cecile
    Monogenic forms of diabetes may account for 1–5% of all cases of diabetes, and may occur in the context of syndromic presentations. We investigated the case of a girl affected by insulin-dependent diabetes, diagnosed at 6 ...
  • Zallloua, Pierre A.; Azar, Sami T.; Delepine, Marc; Makhoul, Nadine J.; Blanc, Herve; Sanyoura, May; Lavergne, Anne; Stankov, Karmen; Lemainque, Arnaud; Baz, Patrick; Julier, Cecile
    Most cases of juvenile-onset diabetes (JOD) are diagnosed as type 1 diabetes (T1D), for which genetic studies conducted in outbred Caucasian populations support the concept of multifactorial inheritance. However, this view ...
  • Ammar, Walid; Kdouh, Ola; Hammoud, Rawan; Hamadeh, Randa; Harb, Hilda; Ammar, Zeina; Atun, Rifat; Christiani, David; Zalloua, Pierre A.
    Background Between 2011 and 2013, the Lebanese population increased by 30% due to the influx of Syrian refugees. While a sudden increase of such magnitude represents a shock to the health system, threatening the continuity ...
  • Deloukas, Panos; Zalloua, Pierre A.
    Coronary artery disease (CAD) is the commonest cause of death. Here, we report an association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching genome-wide significance, taking the number of ...
  • Makhoul, N.J.; Wells, R.S.; Kaspart, H.; Shbaklo, H.; Taher, A.; Chakar, N.; Zalloua, P.A.
    Beta thalassemia is an autosomal recessive disorder characterized by reduced (β+) or absent (β0) beta‐globin chain synthesis. In Lebanon it is the most predominant genetic defect. In this study we investigated the religious ...
  • Haber, Marc; Platt, Daniel E.; Bonab, Maziar Ashrafian; Youhanna, Sonia C.; Soria-Hernanz, David F.; Martínez-Cruz, Begona; Douaihy, Bouchra; Ghassibe-Sabbagh, Michella; Rafatpanah, Hoshang; Ghanbari, Mohsen; Whale, John; Balanovsky, Oleg; Spencer Wells, R.; Comas, David; Tyler-Smith, Chris; Zalloua, Pierre A.
    Afghanistan has held a strategic position throughout history. It has been inhabited since the Paleolithic and later became a crossroad for expanding civilizations and empires. Afghanistan's location, history, and diverse ...
  • Badr, Christian E.; Zalloua, Pierre; Breakefield, Xandra O.; Tannous, Bakhos A.
    Ionizing Radiation (IR)-inducible promoters used as genetic switches for cancer therapy are promising tool for controlling therapeutic gene expression. Here we describe the use of a naturally secreted luciferase from the ...
  • Haber, Marc; Youhanna, Sonia C.; Balanovsky, Oleg; Saade, Stephanie; Martínez‐Cruz, Begona; Ghassibe-Sabbagh, Michella; Shasha, Nabil; Osman, Raed; El Bayeh, Hamid; Koshel, Sergey; Zaporozhchenko, Valery; Balanovska, Elena; Soria‐Hernanz, David F.; Platt, Daniel E.
    Population origins and ancestry have previously been found to be important determinants of coronary artery disease (CAD). This study investigates associations of Lebanese mitochondrial DNA lineages with CAD and studies ...
  • Haber, Marc; Platt, Daniel E.; Khoury, Simon; Badro, Danielle A.; Abboud, Miguel; Tyler-Smith, Chris; Zalloua, Pierre
    We have sought to identify signals of assimilation of African male lines in Lebanon by exploring the association of sickle cell disease (SCD) in Lebanon with Y-chromosome haplogroups that are informative of the disease ...
  • Javed, Asif; Mele, Marta; Pybus, Marc; Zalloua, Pierre; Haber, Marc; Comas, David; Netea, Mihai G.; Balanovsky, Oleg; Balanovsky, Elena; Jin, Li; Yang, Yajun; ArunKumar, GaneshPrasad; Pitchappan, Ramasamy; Bertranpetit, Jaume; Calafell, Francesc
    We have analyzed human genetic diversity in 33 Old World populations including 23 populations obtained through Genographic Project studies. A set of 1,536 SNPs in five X chromosome regions were genotyped in 1,288 individuals ...
  • Taleb, Nadine; Bou Khalil, Pierre; Zantout, Mira S.; Zalloua, Pierre; Azar, Sami T.
    Patients with type 1 diabetes (a TH1 disease) have been reported to be at a lower risk of developing asthma (a TH2 disease). Both diseases are affected by environmental and genetic factors. Our objective is to examine this ...
  • Stolzenburg, Svenja; Lauridsen, Micheal B.; Toft, Henrik; Zalloua, Pierre A.; Baunsgaard, Dorrit
    NMR based metabolic profiling of blood samples in epidemiological studies can be used for molecular phenotyping and biomarker discovery. Often metabolic changes in blood are more subtle and demand a high quality spectrum ...
  • Zalloua, Pierre A.; Aoun, Elie; Koussa, Suzanne; Asfahani, Wissam S.Z.; Taher, Ali
    Thalassemia is a common inherited disease in the Mediterranean region. We here report a mutation new to the Lebanese population: the insertion of a G nucleotide at codons 8/9 [(+G) AAG‐TCT (Lys‐Ser)→AAG‐G‐TCT (β0)] of the ...
  • Chahine, Ramez; Abchee, Antoine; Zalloua, Pierre
    In this study, we measured the excretion rate of nicotine and its two major metabolites, cotinine and trans-3′-hydroxycotinine (THOC), in the urine of 25 healthy smokers and 15 smokers who underwent a coronary artery bypass ...
  • Naja, R.P.; Kaspar, H.; Shbaklo, H.; Chakar, N.; Makhoul, N.J.; Zalloua, P.A.
    β‐Thalassemia is the most common genetic disorder in the Lebanese population. Of the 200 different mutations in the β‐globin gene that leads to thalassemia, the IVSI‐110 (29.87%), IVSI‐6 (20.74%), IVSI‐1 (14.07%), IVSII‐1 ...

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