• Evaluation of prophylactic dosages of Enoxaparin in non-surgical elderly patients with renal impairment 

  Chamoun, Nibal; Ghanem, Hady; Hachem, Ahmad; Hariri, Essa; Lteif, Christelle; Mansour, Hanine; Dimassi, Hani; Zalloum, Richard; Ghanem, Geroges

  Background Thromboprophylaxis dosing strategies using enoxaparin in elderly patients with renal disease are limited, while dose adjustments or monitoring of anti-Xa levels are recommended. We sought to evaluate the efficacy ...
• Encyclopedia of biophysics 

  Roberts, Gordon; Watts, Anthony (Springer, )
• Implementing an interprofessional education programme in Lebanon 

  Farra, Anna; Zeenny, Rony; Nasser, Soumana; Asmar, Nadia; Milane, Aline; Bassil, Maya; Haidar, Mona; Habre, Maha; Zeeni, Nadine; Hoffart, Nancy

  Background: The Lebanese American University has a well-functioning inter-professional education (IPE) programme; this is a fundamental pedagogical approach in healthcare education in which students from different professions ...
• Branched-chain amino acids mediate resilience to chronic social defeat stress by activating BDNF/TRKB signaling 

  Nasrallah, Patrick; Abou Haidar, Edwina; Stephan, Joseph S.; El Hayek, Lauretta; Karnib, Nabil; Khalifeh, Mohamad; Barmo, Nour; Jabre, Vanessa; Houbeika, Rouba; Ghanem, Anthony; Nasser, Jason; Zeeni, Nadine; Bassil, Maya; F. Sleiman, Sama

  How individuals respond to chronic stress varies. Susceptible individuals ultimately develop depression; whereas resilient individuals live normally. In this study, our objective was to examine the effect of branched-chain ...
• The chemotherapeutic effect of β-2-himachalen-6-ol in chemically induced skin tumorigenesis 

  Daaboul, Hamid E.; Dagher, Carole; Taleb, Robin I.; Bodman-Smith, Kikki; Shebaby, Wassim N.; El-Sibai, Mirvat; Mroueh, Mohamad A.; Daher, Costantine F.

  β-2-himachalen-6-ol (HC), a novel sesquiterpene derived from Lebanese wild carrot, was shown to possess a remarkable anticancer activity. The present study investigates the in vitro anticancer activity of HC and its effect ...
• Diabetic ketoacidosis induced by single dose of pembrolizumab 

  Maamari, Julian; Yeung, Sai-Ching J.; Chaftari, Patrick S.

  Immune checkpoint inhibitors are a new class of anticancer drugs recently approved by the US Food and Drug Administration (FDA) for the treatment of various malignancies. Pembrolizumab is an immune checkpoint inhibitor ...
• Juvenile-onset diabetes and congenital cataract 

  Lenfant, Caroline; Baz, Patrick; Degavre, Anne; Phillippi, Anne; Senne, Valerie; Vandiedonck, Claire; Derbois, Celine; Nicolino, Marc; Zalloua, Pierre; Julier, Cecile

  Monogenic forms of diabetes may account for 1–5% of all cases of diabetes, and may occur in the context of syndromic presentations. We investigated the case of a girl affected by insulin-dependent diabetes, diagnosed at 6 ...
• WFS1 mutations are frequent monogenic causes of juvenile-onset diabetes mellitus in Lebanon 

  Zallloua, Pierre A.; Azar, Sami T.; Delepine, Marc; Makhoul, Nadine J.; Blanc, Herve; Sanyoura, May; Lavergne, Anne; Stankov, Karmen; Lemainque, Arnaud; Baz, Patrick; Julier, Cecile

  Most cases of juvenile-onset diabetes (JOD) are diagnosed as type 1 diabetes (T1D), for which genetic studies conducted in outbred Caucasian populations support the concept of multifactorial inheritance. However, this view ...
• Health system resilience 

  Ammar, Walid; Kdouh, Ola; Hammoud, Rawan; Hamadeh, Randa; Harb, Hilda; Ammar, Zeina; Atun, Rifat; Christiani, David; Zalloua, Pierre A.

  Background Between 2011 and 2013, the Lebanese population increased by 30% due to the influx of Syrian refugees. While a sudden increase of such magnitude represents a shock to the health system, threatening the continuity ...
• Large-scale association analysis identifies new risk loci for coronary artery disease 

  Deloukas, Panos; Zalloua, Pierre A.

  Coronary artery disease (CAD) is the commonest cause of death. Here, we report an association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching genome-wide significance, taking the number of ...
• Genetic heterogeneity of beta thalassemia in Lebanon reflects historic and recent population migration 

  Makhoul, N.J.; Wells, R.S.; Kaspart, H.; Shbaklo, H.; Taher, A.; Chakar, N.; Zalloua, P.A.

  Beta thalassemia is an autosomal recessive disorder characterized by reduced (β+) or absent (β0) beta‐globin chain synthesis. In Lebanon it is the most predominant genetic defect. In this study we investigated the religious ...
• Afghanistan's ethnic groups share a Y-chromosomal heritage structured by historical events 

  Haber, Marc; Platt, Daniel E.; Bonab, Maziar Ashrafian; Youhanna, Sonia C.; Soria-Hernanz, David F.; Martínez-Cruz, Begona; Douaihy, Bouchra; Ghassibe-Sabbagh, Michella; Rafatpanah, Hoshang; Ghanbari, Mohsen; Whale, John; Balanovsky, Oleg; Spencer Wells, R.; Comas, David; Tyler-Smith, Chris; Zalloua, Pierre A.

  Afghanistan has held a strategic position throughout history. It has been inhabited since the Paleolithic and later became a crossroad for expanding civilizations and empires. Afghanistan's location, history, and diverse ...
• 956. Imaging of radiation-inducible promotersu using a naturally secreted luciferase from the Marine copepod gaussia princeps 

  Badr, Christian E.; Zalloua, Pierre; Breakefield, Xandra O.; Tannous, Bakhos A.

  Ionizing Radiation (IR)-inducible promoters used as genetic switches for cancer therapy are promising tool for controlling therapeutic gene expression. Here we describe the use of a naturally secreted luciferase from the ...
• mtDNA lineages reveal coronary artery disease‐associated structures in the Lebanese population 

  Haber, Marc; Youhanna, Sonia C.; Balanovsky, Oleg; Saade, Stephanie; Martínez‐Cruz, Begona; Ghassibe-Sabbagh, Michella; Shasha, Nabil; Osman, Raed; El Bayeh, Hamid; Koshel, Sergey; Zaporozhchenko, Valery; Balanovska, Elena; Soria‐Hernanz, David F.; Platt, Daniel E.

  Population origins and ancestry have previously been found to be important determinants of coronary artery disease (CAD). This study investigates associations of Lebanese mitochondrial DNA lineages with CAD and studies ...
• Y-chromosome R-M343 African lineages and sickle cell disease reveal structured assimilation in Lebanon 

  Haber, Marc; Platt, Daniel E.; Khoury, Simon; Badro, Danielle A.; Abboud, Miguel; Tyler-Smith, Chris; Zalloua, Pierre

  We have sought to identify signals of assimilation of African male lines in Lebanon by exploring the association of sickle cell disease (SCD) in Lebanon with Y-chromosome haplogroups that are informative of the disease ...
• Recombination networks as genetic markers in a human variation study of the Old World 

  Javed, Asif; Mele, Marta; Pybus, Marc; Zalloua, Pierre; Haber, Marc; Comas, David; Netea, Mihai G.; Balanovsky, Oleg; Balanovsky, Elena; Jin, Li; Yang, Yajun; ArunKumar, GaneshPrasad; Pitchappan, Ramasamy; Bertranpetit, Jaume; Calafell, Francesc

  We have analyzed human genetic diversity in 33 Old World populations including 23 populations obtained through Genographic Project studies. A set of 1,536 SNPs in five X chromosome regions were genotyped in 1,288 individuals ...
• Prevalence of asthmatic symptoms in Lebanese patients with type 1 diabetes and their unaffected siblings compared to age-matched controls 

  Taleb, Nadine; Bou Khalil, Pierre; Zantout, Mira S.; Zalloua, Pierre; Azar, Sami T.

  Patients with type 1 diabetes (a TH1 disease) have been reported to be at a lower risk of developing asthma (a TH2 disease). Both diseases are affected by environmental and genetic factors. Our objective is to examine this ...
• Improved quality of 1H NMR spectroscopic data for enhanced metabolic profiling of low molecular weight metabolites in human serum Authors Authors and affiliations 

  Stolzenburg, Svenja; Lauridsen, Micheal B.; Toft, Henrik; Zalloua, Pierre A.; Baunsgaard, Dorrit

  NMR based metabolic profiling of blood samples in epidemiological studies can be used for molecular phenotyping and biomarker discovery. Often metabolic changes in blood are more subtle and demand a high quality spectrum ...
• The codons 8/9 (+ G) mutation found for the first time in the Lebanese population 

  Zalloua, Pierre A.; Aoun, Elie; Koussa, Suzanne; Asfahani, Wissam S.Z.; Taher, Ali

  Thalassemia is a common inherited disease in the Mediterranean region. We here report a mutation new to the Lebanese population: the insertion of a G nucleotide at codons 8/9 [(+G) AAG‐TCT (Lys‐Ser)→AAG‐G‐TCT (β0)] of the ...
• Nicotine metabolism in healthy smokers and patients with cardiovascular diseases 

  Chahine, Ramez; Abchee, Antoine; Zalloua, Pierre

  In this study, we measured the excretion rate of nicotine and its two major metabolites, cotinine and trans-3′-hydroxycotinine (THOC), in the urine of 25 healthy smokers and 15 smokers who underwent a coronary artery bypass ...

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