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Browsing School of Arts and Sciences by Author "Singer, Heike"

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Browsing School of Arts and Sciences by Author "Singer, Heike"

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  • Lack of F8 mRNA 
    El Maarri, Osman; Singer, Heike; Klein, Claudia; Watzka, Mathias; Herbiniaux, Brackmann; Schroder, Jorg; Graw, Jochen; Muller, Clemens; Schramm, Wolfgang; Schwaab, Rainer; Haaf, Thomas; Hanfland, Peter; Oldenburg, Johannes (2017-09-13)
    Hemophilia A (HA) is caused by partial or total deficiency of F8 protein activity. In a small group, about 1.8% of patients with HA, no mutation is found in the F8 gene. Among this group, we report here on one patient with ...
  • Methylation at global LINE-1 repeats in human blood are affected by gender but not by age or natural hormone cycles 
    El Maarri, Osman; Walier, Maja; Behne, Frank; Uum, Jan van; Singer, Heike; Diaz-Lacava, Amalia; Nusgen, Nicole; Niemann, Barbara; Watzka, Matthias (2017-09-14)
    Previously, we reported on inter-individual and gender specific variations of LINE-1 methylation in healthy individuals. In this study, we investigated whether this variability could be influenced by age or sex hormones ...
  • Methylation of L1Hs promoters is lower on the inactive X, has a tendency of being higher on autosomes in smaller genomes and shows inter-individual variability at some loci 
    El Maarri, Osman; Singer, Heike; Walier, Maja; Nusgen, Nicole; Meesters, Christian; Schreiner, Felix; Woelfe, Joachim; Wienker, Thomas (2017-09-14)
    LINE-1 repeats account for ∼17% of the human genome. Little is known about their individual methylation patterns, because their repetitive, almost identical sequences make them difficult to be individually targeted. Here, ...
  • NLRP7 inter-domain interactions 
    El Maarri, Osman; Singer, Heike; Biswas, Arijit; Zimmer, Nicole; Messaed, Christiane; Oldenburg, Johannes; Slim, Rima (2017-09-15)
    Mutations in NLRP7 (NOD-like-receptor family, pyrin domain containing 7) are responsible for a type of recurrent pregnancy loss known as recurrent hydatidiform mole (HYDM1). This condition is characterized by abnormal ...

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