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Browsing School of Arts and Sciences by Author "Pang, Huan"

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Browsing School of Arts and Sciences by Author "Pang, Huan"

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  • Cdc42 is required for EGF-stimulated protrusion and motility in MTLn3 carcinoma cells 
    El-Sibai, Mirvat; Nalbant, Peri; Pang, Huan; Flinn, Rory J.; Sarmiento, Corina; Macaluso, Frank; Cammer, Michael; Condeelis, John S.; Hahn, Klaus M.; Backer, Jonathan M. (2015-11-09)
    Cdc42 plays a central role in regulating the actin cytoskeleton and maintaining cell polarity. Here, we show that Cdc42 is crucial for epidermal growth factor (EGF)- stimulated protrusion in MTLn3 carcinoma cells. ...
  • RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells 
    El-Sibai, Mirvat; Pertz, Olivier; Pang, Huan; Yip, Shu-Chin; Lorenz, Mike; Symons, Marc; Condeelis, John S.; Hahn, Klaus M.; Backer, Jonathan M. (2015-11-04)
    Rho GTPases are versatile regulators of cell shape that act on the actin cytoskeleton. Studies using Rho GTPase mutants have shown that, in some cells, Rac1 and Cdc42 regulate the formation of lamellipodia and filopodia, ...

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