INTRODUCTION AND OBJECTIVES Evaluate the potential use of PSA-targeted therapy for the treatment of LUTS 2ry to BPH, through assessment of the safety and tolerability of PRX302, a proaerolysin toxin genetically modified ...

Native proaerolysin is a channel-forming bacterial protoxin that binds to cell-surface receptors and then is activated by furin or furin-like proteases. We genetically engineered proaerolysin by replacing the furin-cleavage ...