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Browsing School of Arts and Sciences by Author "Mashishi, Lata"

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Browsing School of Arts and Sciences by Author "Mashishi, Lata"

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  • Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease 
    Sleiman, Sama F.; Mashishi, Lata; Coppola, Giovanni; Thompson, Leslie M.; Ratan, Rajiv R.; Starkov, Anatoly; Antonyak, Marc A. (2017-09-06)
    Caused by a polyglutamine expansion in the huntingtin protein, Huntington's disease leads to striatal degeneration via the transcriptional dysregulation of a number of genes, including those involved in mitochondrial ...
  • Putting the ‘HAT’ back on survival signalling 
    Sleiman, Sama F.; Basso, Manuela; Mashishi, Lata; Kozikowski, Alan P.; Donohoe, Mary E.; Langley, Brett; Ratan, Rajiv R. (2017-09-06)
    Decreased histone acetyltransferase activity and transcriptional dysfunction have been implicated in almost all neurodegenerative conditions. Increasing net histone acetyltransferase activity through inhibition of the ...

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