Browsing School of Arts and Sciences by Author "Diaz-Lacava, Amalia"

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Gender specific differences in levels of DNA methylation at selected loci from human total blood

El Maarri, Osman; Becker, Tim; Junen, Judith; Manzoor, Syed Saadi; Diaz-Lacava, Amalia (2017-09-13)

Abnormal patterns of DNA methylation are observed in many diseases such as tumors and imprinting disorders. Little is known about inter-individual and gender specific variations. Here, we report on accurate and sensitive ...
Methylation at global LINE-1 repeats in human blood are affected by gender but not by age or natural hormone cycles

El Maarri, Osman; Walier, Maja; Behne, Frank; Uum, Jan van; Singer, Heike; Diaz-Lacava, Amalia; Nusgen, Nicole; Niemann, Barbara; Watzka, Matthias (2017-09-14)

Previously, we reported on inter-individual and gender specific variations of LINE-1 methylation in healthy individuals. In this study, we investigated whether this variability could be influenced by age or sex hormones ...
A systematic search for DNA methyltransferase polymorphisms reveals a rare DNMT3L variant associated with subtelomeric hypomethylation

El Maarri, Osman; Kareta, Micheal S.; Mikeska, Thomas; Becker, Tim; Diaz-Lacava, Amalia; Junen, Judith; Nusgen, Nicole; Behne, Frank; Wienker, Thomas; Waha, Andreas (2017-09-14)

Causes underlying inter-individual variations in DNA methylation profiles among normal healthy populations are not thoroughly understood. To investigate the contribution of genetic variation in DNA methyltransferase (DNMT) ...

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