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Browsing School of Arts and Sciences by Author "Bodman-Smith, Kikki"

Now showing items 1-9 of 9

The antioxidant and anticancer effects of Wild Carrot oil extract

Shebaby, Wassim Nasri; El-Sibai, Mirvat; Bodman-Smith, Kikki; Karam, Marc Christoph; Mroueh, Mohamad; Daher, Costantine F. (2015-11-04)

Daucus carota L. ssp. carota (Apiacea) is used in traditional medicine in Lebanon and in different regions throughout the world. The present study investigates the in vitro anticancer activities of Daucus carota oil extract ...
Antioxidant and hepatoprotective activities of the oil fractions from wild carrot (Daucus carota ssp. carota)

Shebaby, Wassim N.; Daher, Costantine F.; El-Sibai, Mirvat; Bodman-Smith, Kikki; Mansour, Anthony; Karam, Marc C.; Mroueh, Mohamad (2015-12-16)

Context: Wild carrot, Daucus carota L. ssp. carota (Apiacae), is widely distributed throughout the world and has various uses in traditional medicine in Lebanon. Objective: The present study aimed to fractionate and ...
Antitumor activity of β-2-himachalen-6-ol in colon cancer is mediated through its inhibition of the PI3K and MAPK pathways

Daaboul, Hamid E.; Daher, Costantine F.; Bodman-Smith, Kikki; Taleb, Robin I.; Shehaby, Wassim N.; Boulos, Joelle; Dagher, Carole; Mroueh, Mohamad A.; El-Sibai, Mirvat (2017-12-15)

Previous studies in our laboratory showed that Daucus carota oil extract (DCOE) possesses in vitro and in vivo anticancer activities. Chemical analysis of DCOE led to the isolation of β-2-himachalen-6-ol (HC) which exhibited ...
The chemotherapeutic effect of β-2-himachalen-6-ol in chemically induced skin tumorigenesis

Daaboul, Hamid E.; Dagher, Carole; Taleb, Robin I.; Bodman-Smith, Kikki; Shebaby, Wassim N.; El-Sibai, Mirvat; Mroueh, Mohamad A.; Daher, Costantine F. (2019-10-08)

β-2-himachalen-6-ol (HC), a novel sesquiterpene derived from Lebanese wild carrot, was shown to possess a remarkable anticancer activity. The present study investigates the in vitro anticancer activity of HC and its effect ...
Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells

Shebaby, Wassim N.; Mroueh, Mohammad; Bodman-Smith, Kikki; Mansour, Anthony; Taleb, Robin I.; Daher, Costantine F.; El-Sibai, Mirvat (2016-05-16)

Background Daucus carota L.ssp.carota (wild carrot), an herb used in folk medicine worldwide, was recently demonstrated to exhibit anticancer activity. In this study we examined the anticancer effect of Daucus carota oil ...
Enhanced cellular uptake and photochemotherapeutic potential of a lipophilic strained Ru(II) polypyridyl complex

Mehanna, Stephanie; Mansour, Najwa; Audi, Hassib; Bodman-Smith, Kikki; Mroueh, Mohamad A.; Taleb, Robin I.; Daher, Costantine F.; Khnayzer, Rony S. (2019-10-01)

The use of ruthenium complexes as chemotherapeutic agents has been recently explored as one of the alternatives to conventional treatments. In the present study, two Ru(II) polypyridyl complexes were synthesized and ...
Photoactivatable RuII Complex Bearing 2,9‐Diphenyl‐1,10‐phenanthroline: Unusual Photochemistry and Significant Potency on Cisplatin‐Resistant Cell Lines

Mansour, Najwa; Mehanna, Stephanie; Mroueh, Mohamad A.; Audi, Hassib; Bodman-Smith, Kikki; Daher, Costantine F.; Taleb, Robin I.; El-Sibai, Mirvat; Khnayzer, Rony S. (2019-10-01)

The current study investigates [Ru(bipy)2(dpphen)]Cl2 [where bipy = 2,2′‐bipyridine and dpphen = 2,9‐diphenyl‐1,10‐phenanthroline] (complex 1) for photoactivatable chemotherapy (PACT) application on five cancer cell lines. ...
Rapid quantification of ruthenium(II) polypyridyl anti-cancer drugs using a selective ligand dissociation LC-MS/MS method

Mehanna, Stephanie; Bodman-Smith, Kikki; Daher, Costantine F.; Khnayzer, Rony S. (2023-01-11)

Research on Ru anti-cancer drugs is on the rise with many complexes in clinical trials. Inductively coupled plasma-mass spectrometry (ICP-MS) has been the standard technique for bioanalytical studies on Ru and Pt complexes ...
Wild carrot pentane-based fractions suppress proliferation of human HaCaT keratinocytes and protect against chemically-induced skin cancer

Shebaby, Wassim N.; Mroueh, Mohamad A.; Boukamp, Petra; Bodman-Smith, Kikki; Ishac Taleb, Robin; El-Sibai, Mirvat; Daher, Costantine F. (2017-03-14)

Background Previous studies in our laboratory showed that the Lebanese Daucus carota ssp. carota (wild carrot) oil extract possesses in vitro and in vivo anticancer activities. The present study aims to examine the cytotoxic ...

Now showing items 1-9 of 9

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