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Browsing School of Arts and Sciences by Author "Akoury, Elias"

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Browsing School of Arts and Sciences by Author "Akoury, Elias"

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  • The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics 
    Akoury, Elias; Martin, Mackenzie D.; Assimon, Victoria A.; Borysov, Sergiy (2019-03-22)
    The pathological accumulation of abnormally hyperphosphorylated and aggregated tau, a neuronal microtubule (MT)-associated protein that functions to maintain MT stability, is implicated in a number of hereditary and sporadic ...
  • Hsp90-Tau complex reveals molecular basis for specificity in chaperone action 
    Akoury, Elias; Duarte, Afonso M.S.; Didenko, Tatiana; Radil, Martina (2019-03-21)
    Protein folding in the cell relies on the orchestrated action of conserved families of molecular chaperones, the Hsp70 and Hsp90 systems. Hsp70 acts early and Hsp90 late in the folding path, yet the molecular basis of this ...
  • Imbalance of Hsp70 family variants fosters tau accumulation 
    Akoury, Elias; Jinwal, Umesh K.; Abisambra, John C.; Thompson, Andrea D.; Zhang, Juan (2019-03-22)
    Dysfunctional tau accumulation is a major contributing factor in tauopathies, and the heat-shock protein 70 (Hsp70) seems to play an important role in this accumulation. Several reports suggest that Hsp70 proteins can cause ...
  • Inhibition of Tau filament formation by conformational modulation 
    Akoury, Elias; Gajdat, Michal; Pickhardt, Marcus (2019-03-22)
    Antiaggregation drugs play an important role in therapeutic approaches for Alzheimer’s disease. Although a large number of small molecules that inhibit the aggregation of the tau protein have been identified, little is ...
  • Isolation and structural elucidation of rosmarinic acid by nuclear magnetic resonance spectroscopy 
    Akoury, Elias (2019-03-22)
    Lemon balm is a herbal tea known for its therapeutic practice in soothing stomach cramps, indigestion and nausea. One of its chemical components is rosmarinic acid, known for its anti-inflammatory and antiviral activities ...
  • Mechanismus der phenothiazin‐induzierten hemmung der Tau‐aggregation 
    Akoury, Elias; Pickhardt, Marcus; Gajda, Michal; Biernat, Jacek; Mandelkow, Eckhard; Zweckstetter, Markus (2019-03-22)
  • Mechanistic basis of phenothiazine‐driven inhibition of Tau aggregation 
    Akoury, Elias; Pickhardt, Marcus; Gajda, Michal; Biernat, Jacek; Mandelkow, Eckhard; Zweckstetter, Markus (2019-03-21)
    Blues brothers: Aggregation of the Tau protein is a key event in Alzheimer's disease and Tau aggregation inhibitors are important as potential drugs. Phenothiazines, such as methylene blue and its azure derivatives, have ...
  • Molecular mechanisms of Tau protein aggregation inhibition 
    Akoury, Elias (Niedersächsische Staats-und Universitätsbibliothek Göttingen, 2019-03-22)
    Of all neurodegenerative diseases, Alzheimer´s Disease is the most widespread dementia syndrome, exhibiting progressive memory loss and intellectual abilities. One of the pathological hallmarks of this disease is associated ...
  • Remodeling of the conformational ensemble of the repeat domain of tau by an aggregation enhancer 
    Akoury, Elias; Mukrasch, Marco D.; Biernat, Jacek; Tepper, Katharina; Ozenne, Valery; Mandelkow, Eckhard; Blackedge, Martin; Zweckstetter, Markus (2019-03-22)
    Misfolding of the microtubule‐associated protein Tau is a hallmark of Alzheimer disease and several other neurodegenerative disorders. Because of the dynamic nature of the Tau protein, little is known about the changes in ...
  • Surfactant adsorption kinetics in microfluidics 
    Akoury, Elias; Semin, Benoit; Maes, Florine; Riechers, Birte; Gruner, Philipp; Baret, Jean-Christophe (2019-03-22)
    Emulsions are metastable dispersions. Their lifetimes are directly related to the dynamics of surfactants. We design a microfluidic method to measure the kinetics of adsorption of surfactants to the droplet interface, a ...
  • β-Sheet core of Tau paired helical filaments revealed by solid-state NMR 
    Akoury, Elias; Daebel, Venita; Loquet, Antoine; Zweckstetter, Markus (2019-03-21)
    One of the hallmarks of Alzheimer’s disease is the self-assembly of the microtubule-associated protein tau into fibers termed “paired helical filaments” (PHFs). However, the structural basis of PHF assembly at atomic detail ...

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