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Browsing School of Arts and Sciences by Author "Abi-Habib, Ralph"

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Changes in sphingomyelinases, ceramide, Bax, Bcl2, and caspase-3 during and after experimental status epilepticus

Abi-Habib, Ralph; Mikati, Mohamad A.; Zeineh, Michel; El Hokayem, Jimmy; Rahmeh, Amal; El Sabban, Marwan; Usta, Julnar; Dbaibo, Ghassan (2015-11-30)

Status epilepticus (SE) induces a number of events leading to programmed cell death (PCD). The aim of our work is to study the time sequence of activation of different factors in experimental SE (intraperitoneal kainic ...
Doxironide magnetic nanoparticles for selective drug delivery to human acute myeloid leukemia

Abi-Habib, Ralph; Azar, Daniel; El-Boubbou, Kheireddine; Bekdash, Amira (2018-06-13)

We report the development of a chemotherapeutic formulation made of polymeric-stabilized multifunctional magnetic metal oxide nanoparticles (M3NPs) of ferrites loaded with the anticancer drug Doxorubicin (Dox) as a promising ...
Phase 1 and 2 Studies Demonstrate the Safety and Efficacy of Intraprostatic Injection of PRX302 for the Targeted Treatment of Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia

Abi-Habib, Ralph; Denmeade, Samuel R.; Egerdie, Blair; Steinhoff, Gary; Merchant, Rosemina; Pommerville, Peter (2015-11-30)

Background PRX302 is a prostate specific antigen (PSA)–activated pore-forming protein toxin under development as a targeted approach for improving lower urinary tract symptoms (LUTS) caused by benign prostatic hyperplasia ...
PSA-activated proaerolysin as a prostate specific cancer therapy

Abi-Habib, Ralph; Browning, Jeff L.; Singh, Ravibhushan; Carter, Carol; Ortiz, Janelle (2018-06-18)

Native proaerolysin is a channel-forming bacterial protoxin that is activated upon cleavage by host proteases such as furin. PRX302 is an engineered form of proaerolysin in which the furin cleavage site has been replaced ...
Recombinant prostate-specific antigen proaerolysin shows selective protease sensitivity and cell cytotoxicity

Abi-Habib, Ralph; Singh, Ravibhushan; Browning, Jeff L.; Wong, Kevin; Williams, Simon A.; Merchant, Rosemina; Denmeade, Samuel R.; Buckley, Thomas J.; Frankel, Arthur E. (2016-05-11)

Native proaerolysin is a channel-forming bacterial protoxin that binds to cell-surface receptors and then is activated by furin or furin-like proteases. We genetically engineered proaerolysin by replacing the furin-cleavage ...
Targeting the MAP kinase pathway in astrocytoma cells using a recombinant anthrax lethal toxin as a way to inhibit cell motility and invasion

Al-Dimassi, Saleh; Salloum, Gilbert; Saykali, Bechara; Khoury, Oula; Liu, Shihui; Leppla, Stephen H.; Abi-Habib, Ralph; El-Sibai, Mirvat (2016-12-14)

Malignant astrocytomas are highly invasive into adjacent and distant regions of the normal brain. Understanding and targeting cancer cell invasion is an important therapeutic approach. Cell invasion is a complex process ...

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