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Browsing School of Arts and Sciences by Author "El-Sibai, Mirvat"

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Browsing School of Arts and Sciences by Author "El-Sibai, Mirvat"

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  • RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells 
    El-Sibai, Mirvat; Pertz, Olivier; Pang, Huan; Yip, Shu-Chin; Lorenz, Mike; Symons, Marc; Condeelis, John S.; Hahn, Klaus M.; Backer, Jonathan M. (2015-11-04)
    Rho GTPases are versatile regulators of cell shape that act on the actin cytoskeleton. Studies using Rho GTPase mutants have shown that, in some cells, Rac1 and Cdc42 regulate the formation of lamellipodia and filopodia, ...
  • RHOG activates RAC1 through CDC42 leading to tube formation in vascular endothelial cells 
    El Atat, Oula; Fakih, Amira; El-Sibai, Mirvat (2019-10-08)
    Angiogenesis is a hallmark of cancer cell malignancy. The role of the RHO family GTPase RHOG in angiogenesis in vascular endothelial cells has recently been elucidated. However, the regulation of RHOG during this process, ...
  • The Role of Rho GTPases in Motility and Invasion of Glioblastoma Cells 
    Al-Koussa, Houssam; El Atat, Oula; Jaafar, Leila; Tashjian, Hagop; El-Sibai, Mirvat (2020-05-01)
    Astrocytomas are primary malignant brain tumors that originate from astrocytes. Grade IV astrocytoma or glioblastoma is a highly invasive tumor that occur within the brain parenchyma. The Rho family of small GTPases, which ...
  • The Role of Rho GTPases in VEGF Signaling in Cancer Cells 
    El Baba, Nada; Farran, Mohammad; Abi Khalil, Elie; Jaafar, Leila; Fakhoury, Isabelle; El-Sibai, Mirvat (2020-05-01)
    Vascular endothelial growth factors (VEGFs) consist of five molecules (VEGFA through D as well as placental growth factor) which are crucial for regulating key cellular and tissue functions. The role of VEGF and its ...
  • Signaling networks of Rho GTPases in cell motility 
    Hanna, Samer; El-Sibai, Mirvat (2015-12-17)
    The last decades have witnessed an exponential increase in our knowledge of Rho GTPase signaling network which further highlighted the cross talk between these proteins and the complexity of their signaling pathways. In ...
  • The STAR of the DLC family 
    El-Sitt, Sally; El-Sibai, Mirvat (2015-12-17)
    RhoGTPases are defined as a family of 20 small G proteins playing important roles in almost every cellular process. RhoGTPases are guanine nucleotide-binding proteins existing in two forms: the active form which is GTP ...
  • StarD13 
    Jaafar, Leila; Chamseddine, Zeinab; El-Sibai, Mirvat (2020-05-01)
    StarD13 is a tumor suppressor and a GTPase activating protein (GAP) for Rho GTPases. Thus, StarD13 regulates cell survival pathways and induces apoptosis in a p53-dependent and independent manners. In tumors, StarD13 is ...
  • StarD13 is a tumor suppressor in breast cancer that regulates cell motility and invasion 
    Hanna, Samer; Khalil, Bassem; Nasrallah, Anita; Saykali, Bechara A.; Sobh, Rania; Nasser, Selim; El-Sibai, Mirvat (2015-12-18)
    Breast cancer is one of the most commonly diagnosed cancers in women around the world. In general, the more aggressive the tumor, the more rapidly it grows and the more likely it metastasizes. Members of the Rho subfamily ...
  • Targeting the MAP kinase pathway in astrocytoma cells using a recombinant anthrax lethal toxin as a way to inhibit cell motility and invasion 
    Al-Dimassi, Saleh; Salloum, Gilbert; Saykali, Bechara; Khoury, Oula; Liu, Shihui; Leppla, Stephen H.; Abi-Habib, Ralph; El-Sibai, Mirvat (2016-12-14)
    Malignant astrocytomas are highly invasive into adjacent and distant regions of the normal brain. Understanding and targeting cancer cell invasion is an important therapeutic approach. Cell invasion is a complex process ...
  • WASP family members and formin proteins coordinate regulation of cell protrusions in carcinoma cells 
    Sarmiento, Corina; Wang, Weigang; Dovas, Athanassios; Yamaguchi, Hideki; Sidani, Mazen; El-Sibai, Mirvat; Desmarais, Vera; Holman, Holly A.; Kitchen, Susan; Backer, Jonathan M.; Alberts, Art; Condeelis, John (2017-02-08)
    We examined the role of the actin nucleation promoters neural Wiskott-Aldrich syndrome protein (N-WASP) and WAVE2 in cell protrusion in response to epidermal growth factor (EGF), a key regulator in carcinoma cell invasion. ...
  • Wild carrot pentane-based fractions suppress proliferation of human HaCaT keratinocytes and protect against chemically-induced skin cancer 
    Shebaby, Wassim N.; Mroueh, Mohamad A.; Boukamp, Petra; Bodman-Smith, Kikki; Ishac Taleb, Robin; El-Sibai, Mirvat; Daher, Costantine F. (2017-03-14)
    Background Previous studies in our laboratory showed that the Lebanese Daucus carota ssp. carota (wild carrot) oil extract possesses in vitro and in vivo anticancer activities. The present study aims to examine the cytotoxic ...
  • β-2-himachalen-6-ol 
    Taleb, Robin I.; Najm, Paul; Shebaby, Wassim; Boulos, Joelle C.; Demirdjian, Sally; Hariri, Essa; El-Sibai, Mirvat; Daher, Costantine; Mroueh, Mohamad (2016-10-13)
    Daucus carota ssp. carota, also known as wild carrot, is a commonly used herb in Lebanese folk medicine to treat several ailments including cancer. Previous studies in our laboratories showed that the Daucus carota oil ...
  • β-2-himachalen-6-ol protects against skin cancer development in vitro and in vivo 
    Daaboul, Hamid E.; Daher, Costantine F.; Taleb, Robin I.; Boulos, Joelle; Bodman‐Smith, Kikki; Boukamp, Petra; Shebaby, Wassim N.; Dagher, Carol; El-Sibai, Mirvat; Mroueh, Mohamad A. (2017-12-15)
    Background Previous studies in our laboratory showed that Daucus carota oil extract (DCOE) possesses remarkable in-vitro anticancer activity and antitumour promoting effect against DMBA/TPA skin carcinogenesis in mice. ...

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