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Browsing School of Arts and Sciences by Author "El-Sibai, Mirvat"

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Browsing School of Arts and Sciences by Author "El-Sibai, Mirvat"

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  • Geographical Structure of the Y-chromosomal Genetic Landscape of the Levant 
    El-Sibai, Mirvat; Platt, Daniel E.; Haber, Marc; Xue, Yali; Youhanna, Sonia C.; Wells, R. Spencer; Izaabel, Hassan; Sanyoura, May F.; Harmanani, Haidar; Bonab, Maziar Ashrafian; Behbehani, Jaafar; Hashwa, Fuad; Tyler-Smith, Chris; Zalloua, Pierre A.; The Genographic Consortium (2015-11-04)
    We have examined the male-specific phylogeography of the Levant and its surroundings by analyzing Y-chromosomal haplogroup distributions using 5874 samples (885 new) from 23 countries. The diversity within some of these ...
  • Hepatoprotective, Antioxidant, and Anticancer Effects of the Tragopogon porrifolius Methanolic Extract 
    Tenkerian, Clara; El-Sibai, Mirvat; Daher, Costantine F.; Mroueh, Mohamad (2015-12-16)
    Tragopogon porrifolius (Asteraceae), commonly referred to as white salsify, is an edible herb used in Lebanese folk medicine to treat cancer and liver dysfunction. In this study, we investigated the antioxidant activity ...
  • Human recombinant arginase I (Co)-PEG5000 [HuArgI (Co)-PEG5000]-induced arginine depletion is selectively cytotoxic to human glioblastoma cells 
    Khoury, Oula; Ghazale, Noura; Stone, Everett; El-Sibai, Mirvat; Frankel, Arthur; Abi-Habib, Ralph J. (2015-12-01)
    In this study, we attempt to target Arginine auxotrophy in glioblastoma multiforme (GBM) cells using a pegylated recombinant human Arginase I cobalt [HuArgI (Co)-PEG5000]. We tested and characterized the activity of HuArgI ...
  • The I allele of the angiotensin converting enzyme I/D polymorphism confers protection against coronary artery disease 
    Abchee, Antoine; El-Sibai, Mirvat; Youhanna, Sonia; Yeretzian, Joumana S.; Hanine, Estephan; Makhoul, Nadine J.; Puzantian, Houry; Sawaya, Jaber; Nasrallah, Antoine; Rebeiz, Abdallah G.; Zreik, Tony G.; Azar, Sami T.; Zalloua, Pierre A. (2017-07-27)
    Background: Mutations in genes regulating lipid metabolism, vasoactivity, and coagulation are important modulators of coronary artery disease (CAD). Objective: This study investigated the association between allelic ...
  • IL-1 stimulates ceramide accumulation without inducing apoptosis in intestinal epithelial cells 
    Homaidan, Fadia R.; El-Sabban, Marwan E.; Chakroun, Iman; El-Sibai, Mirvat; Dbaibo, Ghassan S. (2016-04-11)
    Background: In inflammatory bowel disease (IBD), cytokine levels (such as interleukin-1 (IL-1)) are elevated. We have shown previously that IL-1 activates phospholipid signaling pathways in intestinal epithelial cells ...
  • Influences of history, geography, and religion on genetic structure 
    Haber, Marc; Platt, Daniel E.; Badro, Danielle A.; Xue, Yali; El-Sibai, Mirvat; Bonab, Maziar Ashrafian; Youhanna, Sonia C.; Saade, Stephanie; Soria-Hernanz, David F.; Royyuru, Ajay; Wells, R. Spencer; Tyler-Smith, Chris; Zalloua, Pierre A. (2017-08-10)
    Cultural expansions, including of religions, frequently leave genetic traces of differentiation and in-migration. These expansions may be driven by complex doctrinal differentiation, together with major population migrations ...
  • Invadopodia, Regulation, and Assembly in Cancer Cell Invasion 
    Saykali, Bechara A.; El-Sibai, Mirvat (2015-12-18)
    The occurrence of invadopodia has been, since its characterization, a hallmark of cancerous cell invasion and metastasis. These structures are now the subject of a controversy concerning their cellular function, molecular ...
  • Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion 
    Khoury, Nathalie; El-Hayek, Stephany; Tarras, Omayr; El Sabban, Marwan; El-Sibai, Mirvat; Rizk, Sandra (2015-12-18)
    Kefir, a fermented milk product, exhibits anti‑tumoral activity in vivo; yet its mechanism of action remains elusive. Recent studies have focused on the mechanism of action of kefir on cancer cells in vitro. The current ...
  • A long-lived cuprous bis-phenanthroline complex for the photodynamic therapy of cancer 
    Al Hageh, Cynthia; Al Assaad, Majd; El Masri, Zeinab; Samaan, Nawar; El-Sibai, Mirvat; Khalil, Christian; Khnayzer, Rony S. (2018-05-11)
    Copper is an earth-abundant and a biologically essential metal that offers a promising alternative to noble metals in photochemistry and photobiology. In this work, a series of sterically encumbered Cu(I) bis-phenanthroline ...
  • Metformin treatment inhibits motility and invasion of glioblastoma cancer cells 
    Al Hassan, Marwa; Fakhoury, Isabelle; El Masri, Zeinab; Ghazale, Noura; Dennaoui, Rayane; El Atat, Oula; Kanaan, Amjad; El-Sibai, Mirvat (2019-10-08)
    Glioblastoma multiforme (GBM) is one of the most common and deadliest cancers of the central nervous system (CNS). GBMs high ability to infiltrate healthy brain tissues makes it difficult to remove surgically and account ...
  • Mining breast cancer genetic data 
    Mansour, Nashat; Zantout, Rouba; El-Sibai, Mirvat (IEEELebanese American University, 2018-05-11)
    Analyzing breast cancer gene expression data is a very challenging problem due to the large amount of genes examined. Computational techniques have proved reliable to make sense of large amounts of data like the data ...
  • Over‐expression of the p110β but not p110α isoform of PI 3‐kinase inhibits motility in breast cancer cells 
    Yip, Shu-Chin; El-Sibai, Mirvat; Hill, Karen M.; Wu, Haiyan; Fu, Zheng; Condeelis, John S.; Backer, Jonathan M. (2015-11-09)
    Phosphoinositide 3-kinase (PI 3-kinase) activity is required for growth factor-induced cytoskeletal regulation and cell migration. We previously found that in MTLn3 rat adenocarcinoma cells, EGF-stimulated induction of ...
  • Palladin regulation of the actin structures needed for cancer invasion 
    Najm, Paul; El-Sibai, Mirvat (2015-12-17)
    Cell migration and invasion involve the formation of cell adhesion structures as well as the dynamic and spatial regulation of the cytoskeleton. The adhesive structures known as podosomes and invadopodia share a common ...
  • Phospholipase C negatively regulates Rac/Cdc42 activation in antigen-stimulated mast cells 
    El-Sibai, Mirvat; Backer, Jonathan M. (2015-11-09)
    The Rho GTPases Rac and Cdc42 play a central role in the regulation of secretory and cytoskeletal responses in antigen-stimulated mast cells. In this study, we examine the kinetics and mechanism of Rac and Cdc42 activation ...
  • Photoactivatable RuII Complex Bearing 2,9‐Diphenyl‐1,10‐phenanthroline: Unusual Photochemistry and Significant Potency on Cisplatin‐Resistant Cell Lines 
    Mansour, Najwa; Mehanna, Stephanie; Mroueh, Mohamad A.; Audi, Hassib; Bodman-Smith, Kikki; Daher, Costantine F.; Taleb, Robin I.; El-Sibai, Mirvat; Khnayzer, Rony S. (2019-10-01)
    The current study investigates [Ru(bipy)2(dpphen)]Cl2 [where bipy = 2,2′‐bipyridine and dpphen = 2,9‐diphenyl‐1,10‐phenanthroline] (complex 1) for photoactivatable chemotherapy (PACT) application on five cancer cell lines. ...
  • Phototoxicity of strained Ru(II) complexes 
    Azar, Daniel F.; Audi, Hassib; Farhat, Stephanie; El-Sibai, Mirvat; Abi-Habib, Ralph J.; Khnayzer, Rony S. (2017-11-03)
    A photochemically dissociating ligand in Ru(bpy)2(dmphen)Cl2 [bpy = 2,2′-bipyridine; dmphen = 2,9-dimethyl-1,10-phenanthroline] was found to be more cytotoxic on the ML-2 Acute Myeloid Leukemia cell line than Ru(bpy)2(H2O)22+ ...
  • Regulation of Class IA PI 3-kinases 
    Wu, Haiyan; Shekar, S. Chandra; Flinn, Rory J.; El-Sibai, Mirvat; Jaiswal, Bijay S.; Sen, K. Ilker; Janakiraman, Vasantharajan; Seshagiri, Somasekar; Gerfen, Gary J.; Girvin, Mark E.; Backer, Jonathan M. (2015-11-04)
    We previously proposed a model of Class IA PI3K regulation in which p85 inhibition of p110α requires (i) an inhibitory contact between the p85 nSH2 domain and the p110α helical domain, and (ii) a contact between the p85 ...
  • The regulation of RhoA at focal adhesions by StarD13 is important for astrocytoma cell motility 
    Khalil, Bassem D.; Hanna, Samer; Saykali, Bechara A.; El-Sitt, Sally; Nasrallah, Anita; Marston, Daniel; El-Sabban, Marwan; Hahn, Klaus M.; Symons, Marc; El-Sibai, Mirvat (2017-02-08)
    Malignant astrocytomas are highly invasive into adjacent and distant regions of the normal brain. Rho GTPases are small monomeric G proteins that play important roles in cytoskeleton rearrangement, cell motility, and tumor ...
  • Rho A and Rac1 
    Salloum, Gilbert; Jaafar, Leila; El-Sibai, Mirvat (2020-05-01)
    Cells detect external stimuli through cell-surface receptors. In cases where the stimulus is a cytokine or a growth factor, the cell responds by inducing modifications in the actin cytoskeleton. These changes are mediated ...
  • Rho GTPases in primary brain tumor malignancy and invasion 
    Khalil, Bassem D.; El-Sibai, Mirvat (2015-11-04)
    Gliomas are the most common type of malignant primary brain tumor in humans, accounting for 80 % of malignant cases. Expression and activity of Rho GTPases, which coordinate several cellular processes including ...

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