Role of neoadjuvant treatment in clinical T2N0M0 oesophageal cancer

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dc.contributor Chemaly, Rodrigue
dc.contributor.author Markar, Sheraz R.
dc.contributor.author Gronnier, Caroline
dc.contributor.author Pasquer, Arnaud
dc.contributor.author Duhamel, Alain
dc.contributor.author Beal, Hélène
dc.contributor.author Théreaux, Jérémie
dc.contributor.author Gagnière, Johan
dc.contributor.author Lebreton, Gil
dc.contributor.author Brigand, Cécile
dc.contributor.author Meunier, Bernard
dc.contributor.author Collet, Denis
dc.contributor.author Mariette, Christophe
dc.date.accessioned 2022-11-04T14:34:48Z
dc.date.available 2022-11-04T14:34:48Z
dc.date.copyright 2016 en_US
dc.date.issued 2022-11-04
dc.identifier.issn 0959-8049 en_US
dc.identifier.uri http://hdl.handle.net/10725/14217
dc.description.abstract Aims The aims of this study were to compare short- and long-term outcomes for clinical T2N0 oesophageal cancer with analysis of (i) primary surgery (S) versus neoadjuvant therapy plus surgery (NS), (ii) squamous cell carcinoma and adenocarcinoma subsets; and (iii) neoadjuvant chemoradiotherapy versus neoadjuvant chemotherapy. Methods Data were collected from 30 European centres from 2000 to 2010. Among 2944 included patients, 355 patients (12.1%) had cT2N0 disease; 285 (S) and 70 (NS), were compared in terms of short- and long-term outcomes. Propensity score matching analyses were used to compensate for differences in baseline characteristics. Results No significant differences between the groups were shown in terms of in hospital morbidity and mortality. Nodal disease was observed in 50% of S-group at the time of surgery, with 20% pN2/N3. Utilisation of neoadjuvant therapy was associated with significant tumour downstaging as reflected by increases in pT0, pN0 and pTNM stage 0 disease, this effect was further enhanced with neoadjuvant chemoradiotherapy. After adjustment on propensity score and confounding factors, for all patients and subset analysis of squamous cell and adenocarcinoma, neoadjuvant therapy had no significant effect upon survival or recurrence (overall, loco-regional, distant or mixed) compared to surgery alone. There were no significant differences between neoadjuvant chemotherapy and chemoradiotherapy in short- or long-term outcomes. Conclusion The results of this study suggest that a surgery alone treatment approach should be recommended as the primary treatment approach for cT2N0 oesophageal cancer despite 50% of patients having nodal disease at the time of surgery. en_US
dc.language.iso en en_US
dc.title Role of neoadjuvant treatment in clinical T2N0M0 oesophageal cancer en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle results from a retrospective multi-center European study en_US
dc.author.school SOM en_US
dc.author.idnumber 201805037 en_US
dc.author.department N/A en_US
dc.relation.journal European Journal of Cancer en_US
dc.journal.volume 56 en_US
dc.article.pages 59-68 en_US
dc.keywords Oesophageal cancer en_US
dc.keywords cT2N0M0 en_US
dc.keywords Surgery en_US
dc.keywords Neoadjuvant treatment en_US
dc.keywords Survival en_US
dc.keywords Review en_US
dc.identifier.doi https://doi.org/10.1016/j.ejca.2015.11.024 en_US
dc.identifier.ctation Markar, S. R., Gronnier, C., Pasquer, A., Duhamel, A., Beal, H., Théreaux, J., ... & Bertrand, C. (2016). Role of neoadjuvant treatment in clinical T2N0M0 oesophageal cancer: results from a retrospective multi-center European study. European Journal of Cancer, 56, 59-68. en_US
dc.author.email rodrigue.chemaly@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://www.sciencedirect.com/science/article/pii/S0959804915011326 en_US
dc.note Contributors: FREGAT Working Group-FRENCH-AFC en_US
dc.orcid.id https://orcid.org/0000-0002-3670-6027 en_US
dc.author.affiliation Lebanese American University en_US

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