Survival Benefit of Neoadjuvant Treatment in Clinical T3N0M0 Esophageal Cancer

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dc.contributor Chemaly, Rodrigue
dc.contributor.author Mantziari, Styliani
dc.contributor.author Gronnier, Caroline
dc.contributor.author Renaud, Florence
dc.contributor.author Duhamel, Alain
dc.contributor.author Théreaux, Jérémie
dc.contributor.author Brigand, Cécile
dc.contributor.author Carrère, Nicolas
dc.contributor.author Lefevre, Jérémie H.
dc.contributor.author Pasquer, Arnaud
dc.contributor.author Demartines, Nicolas
dc.contributor.author Collet, Denis
dc.contributor.author Meunier, Bernard
dc.contributor.author Mariette, Christophe
dc.date.accessioned 2022-11-02T14:51:29Z
dc.date.available 2022-11-02T14:51:29Z
dc.date.copyright 2017 en_US
dc.date.issued 2022-11-02
dc.identifier.issn 0003-4932 en_US
dc.identifier.uri http://hdl.handle.net/10725/14208
dc.description.abstract Background: Based on current guidelines, clinical T3N0M0 esophageal tumors may or may not receive neoadjuvant treatment, according to their perception as locally advanced (cT3) or early-stage tumors (stage II). The study aim was to assess the impact of neoadjuvant treatment upon survival for cT3N0M0 esophageal cancer patients, with subgroup analyses by histological type (squamous cell carcinoma vs adenocarcinoma) and type of neoadjuvant treatment (chemotherapy vs radiochemotherapy). Methods: Data from patients operated on for esophageal cancer in 30 European centers were collected. Among the 382 of 2944 patients with clinical T3N0M0 stage at initial diagnosis (13.0%), we compared those treated with primary surgery (S, n = 193) versus with neoadjuvant treatment plus surgery (NS, n = 189). Results: The S and NS groups were similar regarding their demographic and surgical characteristics. In-hospital postoperative morbidity and mortality rates were comparable between groups. Patients were found to be pN+ in 64.2% versus 42.9% in the S and NS groups respectively (P < 0.001), pN2/N3 in 35.2% versus 21.2% (P < 0.001), stage 0 in 0% versus 16.4% (P < 0.001), and R0 in 81.3% versus 89.4% of cases (P = 0.026). Median overall and disease-free survivals were significantly better in the NS group, 38.4 versus 27.9 months (P = 0.007) and 31.6 versus 27.5 months (P = 0.040), respectively, and this difference remained for both histological types. Radiotherapy did not offer a benefit compared with chemotherapy alone (P = 0.687). In multivariable analysis, neoadjuvant treatment was an independent favorable prognostic factor (HR 0.76, 95% CI 0.58–0.99, P = 0.044). Conclusion: Neoadjuvant treatment offers a significant survival benefit for clinical T3N0M0 esophageal cancer. en_US
dc.language.iso en en_US
dc.title Survival Benefit of Neoadjuvant Treatment in Clinical T3N0M0 Esophageal Cancer en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle Results From a Retrospective Multicenter European Study en_US
dc.author.school SOM en_US
dc.author.idnumber 201805037 en_US
dc.author.department N/A en_US
dc.relation.journal Annals of Surgery en_US
dc.journal.volume 266 en_US
dc.journal.issue 5 en_US
dc.article.pages 805-813 en_US
dc.identifier.doi https://doi.org/10.1097/SLA.0000000000002402 en_US
dc.identifier.ctation Mantziari, S., Gronnier, C., Renaud, F., Duhamel, A., Théreaux, J., Brigand, C., ... & FREGAT working group–FRENCH. (2017). Survival Benefit of Neoadjuvant Treatment in Clinical T3N0M0 Esophageal Cancer: Results From a Retrospective Multicenter European Study. Annals of surgery, 266(5), 805-813. en_US
dc.author.email rodrigue.chemaly@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://pubmed.ncbi.nlm.nih.gov/28742698/ en_US
dc.note Collaborators: FREGAT working group – FRENCH – AFC en_US
dc.orcid.id https://orcid.org/0000-0002-3670-6027 en_US
dc.author.affiliation Lebanese American University en_US

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