Potential Therapeutic Effects of Lebanese Cannabis oil in Female Mouse Models of Neuropsychiatric Disorders

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dc.contributor.author Hatoum, Fatina
dc.date.accessioned 2022-11-02T10:45:54Z
dc.date.available 2022-11-02T10:45:54Z
dc.date.copyright 2022 en_US
dc.date.issued 2022-07-14
dc.identifier.uri http://hdl.handle.net/10725/14202
dc.description.abstract The Cannabis plant is the most versatile herbal remedy used for the treatment of various medical conditions, including pain, epilepsy, depression, anxiety, and post-traumatic stress disorder. Stress is a normal part of life, and stress responses can vary in different people. Stress-susceptible individuals become prone to depression, while resilient individuals lead a normal life. Limited literature is available about the pharmacological effects of Lebanese Cannabis oil on depression and anxiety disorders. Accordingly, the current research study examined the therapeutic effects of Cannabis oil extracted from the Lebanese Cannabis sativa plant on resilience to stress and its ability to rescue depression and anxiety-like behaviors in female animal models. Pre-treatment and post-treatment protocols were carried out using Cannabis oil to evaluate its anti-depressive effects. In the pre-treatment protocol, female C57BL/6 mice received daily injections of Cannabis oil (5 mg/kg and 20 mg/kg) for five days before and during the induction of depression-like behavior by using several types of stressors for nine days. At the end of the stress paradigm, the animal behavioral was assessed using the social interaction (SI) test. In the post-treatment protocol, female C57BL/6 mice were subjected to daily Chronic Variable Stress (CVS) for nine days. On day 10, the behavior of the mice was assessed using the SI test and animals were divided into susceptible or resilient to stress. Only animals that were classified as susceptible to stress received vehicle or Lebanese Cannabis oil i.p injection treatment (doses of 5 mg/kg and 20 mg/kg). The results showed that intraperitoneal injections of Lebanese Cannabis oil at doses of 5 mg/kg and 20 mg/kg rescued depression-like behaviors induced by the CVS. Therefore, Cannabis oil significantly rescues social avoidance behavior and promotes social interaction. These promising findings call for additional studies to gain a better understanding of the potential effect of Lebanese Cannabis oil on stress and anxiety disorders by studying the effects of whole plant or its major phytocannabinoids, Cannabidiol (CBD) and/or tetrahydrocannabinol (THC). en_US
dc.language.iso en en_US
dc.subject Cannabis -- Therapeutic use en_US
dc.subject Cannabinoids -- Physiological effect en_US
dc.subject Neurobehavioral disorders -- Treatment en_US
dc.subject Depression, Mental -- Treatment en_US
dc.subject Lebanese American University -- Dissertations en_US
dc.subject Dissertations, Academic en_US
dc.title Potential Therapeutic Effects of Lebanese Cannabis oil in Female Mouse Models of Neuropsychiatric Disorders en_US
dc.type Thesis en_US
dc.term.submitted Summer en_US
dc.author.degree MS in Pharmaceutical Development And Management en_US
dc.author.school SOP en_US
dc.author.idnumber 201404480 en_US
dc.author.commembers Shebaby, Wassim
dc.author.commembers Faour, Wissam
dc.author.department Pharmaceutical Sciences en_US
dc.description.physdesc 1 online resource (xiii, 71 leaves): ill. (some col.) en_US
dc.author.advisor Mroueh, Mohamad
dc.author.advisor Sleiman, Sama
dc.keywords Lebanese Cannabis oil en_US
dc.keywords Chronic Variable Stress en_US
dc.keywords Social Interaction en_US
dc.keywords Anxiety en_US
dc.keywords Elevated Plus Maze en_US
dc.keywords Open Field en_US
dc.keywords Depression en_US
dc.description.bibliographiccitations Includes bibliographical references (leaves 50-71) en_US
dc.identifier.doi https://doi.org/10.26756/th.2022.506
dc.author.email fatina.hatoum@lau.edu en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php en_US
dc.publisher.institution Lebanese American University en_US
dc.author.affiliation Lebanese American University en_US

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