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Exercise-induced a-ketoglutarate enhances spatial learning by modulating hippocampal levels of BDNF in a sex-specific manner

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dc.contributor.author Al Ahmad, Perla
dc.date.accessioned 2022-10-25T09:08:40Z
dc.date.available 2022-10-25T09:08:40Z
dc.date.copyright 2022 en_US
dc.date.issued 2022-07-05
dc.identifier.uri http://hdl.handle.net/10725/14125
dc.description.abstract Exercise promotes the release of proteins and metabolites known as exercise factors from the muscles, liver, and bones into the blood. The exercise factors increase hippocampal levels of brain-derived neurotrophic factor (BDNF) which mediates the benefits of exercise on cognition. Identifying these exercise factors would elucidate the mechanisms underlying the benefits of exercise. In this study we examined the effects of the tricarboxylic acid cycle intermediate a-ketoglutarate (aKG) onacognition in both males and females to uncover any sex differences considering theanew NIH guidelines to factor sex as a variable in research. We report that aKG isareleased in the serum of males following forced resistance exercise and voluntary endurance exercise. In contrast, aKG is released in the serum of females only following voluntary endurance exercise. We used the Morris water maze test to investigate the effects of aKG on spatial learning and memory formation. We report that the administration of exogenous aKG enhances spatial learning but not memory in both males and females. This enhanced learning is associated with an increase in hippocampal BDNF and FNDC5 levels in females only. In males, aKG does not to induce hippocampal FNDC5/BDNF, and therefore promotes learning through a yet unknown mechanism. Overall, our results reveal one of the mechanism through which exercise enhances BDNF and promotes learning in females. en_US
dc.language.iso en en_US
dc.subject Neurotrophic functions en_US
dc.subject Hippocampus (Brain) -- Physiology en_US
dc.subject Exercise -- Physiological aspects en_US
dc.subject Cognition -- Effect of exercise on en_US
dc.subject Memory -- Physiological aspects en_US
dc.subject Learning -- Physiological aspects en_US
dc.subject Lebanese American University -- Dissertations en_US
dc.subject Dissertations, Academic en_US
dc.title Exercise-induced a-ketoglutarate enhances spatial learning by modulating hippocampal levels of BDNF in a sex-specific manner en_US
dc.type Thesis en_US
dc.term.submitted Summer en_US
dc.author.degree Doctor of Pharmacy en_US
dc.author.school SAS en_US
dc.author.idnumber 201702023 en_US
dc.author.commembers Khalaf, Roy
dc.author.commembers Stephan, Joseph
dc.author.department Natural Sciences en_US
dc.description.physdesc 1 online resource (xi, 40 leaves): ill. (some col.) en_US
dc.author.advisor Sleiman, Sama
dc.keywords Exercise en_US
dc.keywords Exercise Factors en_US
dc.keywords BDNF en_US
dc.keywords Learning en_US
dc.keywords Memory en_US
dc.keywords a-ketoglutarate en_US
dc.description.bibliographiccitations Includes bibliographical references (leaves 30-40). en_US
dc.identifier.doi https://doi.org/10.26756/th.2022.453
dc.author.email perla.elahmad@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php en_US
dc.publisher.institution Lebanese American University en_US
dc.author.affiliation Lebanese American University en_US


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