Efficacy and Toxicity of Hand Sanitizers

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dc.contributor.author Zgheib, Rebecca
dc.date.accessioned 2022-06-22T09:29:00Z
dc.date.available 2022-06-22T09:29:00Z
dc.date.copyright 2022 en_US
dc.date.issued 2022-01-14
dc.identifier.uri http://hdl.handle.net/10725/13747
dc.description.abstract Since the outbreak of Coronavirus Disease 2019 (CoVID-19), the World Health Organization has suggested that alcohol-based hand sanitizers should be used in the absence of soap and water to prevent the spread of SARS-CoV2. This study aimed to assess the efficacy and toxicity of hand sanitizers produced and/or distributed on the Lebanese market. The study included 31 different brands of hand sanitizers that were analyzed using headspace gas chromatography- mass spectrometry to detect impurities and alcohol content. The impurities were identified based on a Mass Spectrometry database. Regression analysis was used to determine ethanol percentage. Accordingly, a toxicological review was conducted to assess the various risks associated with the usage of hand sanitizers. Detected impurities mainly included but not limited to ethyl acetate, benzene, acetone, and acetal. Among the ethanol-containing hand sanitizers, 71% contained less than 60% v/v alcohol not complying with the CDC and WHO recommendations which state that ethanol concentration should be at least 60%. Isobutanol and other non-recommended alcohols (methanol and 1-propanol) were also detected as contaminations. Consumers should be aware that some hand sanitizers available on the Lebanese market are ineffective and include residues of harmful substances. en_US
dc.language.iso en en_US
dc.subject Hand -- Care and hygiene en_US
dc.subject Hand washing en_US
dc.subject Antiseptics en_US
dc.subject COVID-19 (Disease) -- Prevention en_US
dc.subject Lebanese American University -- Dissertations en_US
dc.subject Dissertations, Academic en_US
dc.title Efficacy and Toxicity of Hand Sanitizers en_US
dc.type Thesis en_US
dc.title.subtitle Detection of Impurities and Evaluation of Alcohol Content en_US
dc.term.submitted Fall en_US
dc.author.degree MS in Pharmaceutical Development And Management en_US
dc.author.school SOP en_US
dc.author.idnumber 201402308 en_US
dc.author.commembers Knoayzer, Rony
dc.author.commembers Mehanna, Rony
dc.author.department Pharmaceutical Sciences en_US
dc.description.physdesc 1 online resource (xiii, 59 leaves): ill. (some col.) en_US
dc.author.advisor Saab, Yolande
dc.keywords Hand Sanitizer en_US
dc.keywords COVID-19 en_US
dc.keywords Impurities en_US
dc.keywords Headspace Gas Chromatography en_US
dc.keywords Alcohol Content en_US
dc.description.bibliographiccitations Includes bibliographical references (leaf 47-54). en_US
dc.identifier.doi https://doi.org/10.26756/th.2022.179
dc.author.email rebecca.zgheib@lau.edu en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php en_US
dc.publisher.institution Lebanese American University en_US
dc.author.affiliation Lebanese American University en_US

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