The Roles of Palladin & Cdc42 on Migration in Glioblastoma Cells

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dc.contributor.author Dawali, Katia
dc.date.accessioned 2022-06-22T09:17:50Z
dc.date.available 2022-06-22T09:17:50Z
dc.date.copyright 2021 en_US
dc.date.issued 2022-01-04
dc.identifier.uri http://hdl.handle.net/10725/13744
dc.description.abstract Glioblastoma multiforme is one of the deadliest cancers with 30 years of very little progression in its treatment and prognosis. In addition to all complexity that is associated with cancer, Glioblastoma is a multiform with multiple morphologies, genetic variations, alteration and appearances. It can either arise from a metastatic cancer in the body or as a primary tumor of the brain. Palladin has been shown to have different roles regarding metastasis and invasion. In some studies, it promoted invasion and in others it functioned as a negative regulator of invasion. Moreover, it can affect tumorigenesis through a possible cross talk with rho GTPases such as Cdc42 and Rac1 that have closely related morphology. In this study, we investigated the roles of palladin and Cdc42 on migration in distinct GBM cell lines. Our results show that palladin played opposite roles in terms of migration in the different cell lines. Moreover, we found out that in A172 calls palladin negatively regulates migration and Cdc42 expression suggesting the possible cross talk between the two proteins and a role of this crosstalk in migration. On the other hand, in SNB-19 cells both palladin and Cdc42 seemed to be positive regulators of migration and no cross talk took place. en_US
dc.language.iso en en_US
dc.subject Glioblastoma multiforme en_US
dc.subject Rho GTPases en_US
dc.subject Metastasis en_US
dc.subject Cell migration en_US
dc.subject Lebanese American University -- Dissertations en_US
dc.subject Dissertations, Academic en_US
dc.title The Roles of Palladin & Cdc42 on Migration in Glioblastoma Cells en_US
dc.type Thesis en_US
dc.term.submitted Fall en_US
dc.author.degree Doctor of Pharmacy en_US
dc.author.school SAS en_US
dc.author.idnumber 201501489 en_US
dc.author.commembers Khalaf, Roy
dc.author.commembers Ghassibe-Sabbagh, Michella
dc.author.department Natural Sciences en_US
dc.description.physdesc 1 online resource (xii, 40 leaves): ill. (some col.) en_US
dc.author.advisor El Sibai, Mirvat
dc.keywords Glioblastoma en_US
dc.keywords Palladin en_US
dc.keywords Cell invasion en_US
dc.keywords Migration en_US
dc.keywords Rho GTPases en_US
dc.keywords Cdc42 en_US
dc.keywords Rac1 en_US
dc.description.bibliographiccitations Includes bibliographical references (leaf 29-40). en_US
dc.identifier.doi https://doi.org/10.26756/th.2022.182
dc.author.email katia.dawali@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php en_US
dc.publisher.institution Lebanese American University en_US
dc.author.affiliation Lebanese American University en_US

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