Evaluation Of Anti Thyroid Activity of Cannabis Sativa Oil Extract Against Levothyroxine Induced Hyperthyroidism in Mice

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dc.contributor.author Al Sayed, Dania
dc.date.accessioned 2022-06-22T08:27:41Z
dc.date.available 2022-06-22T08:27:41Z
dc.date.copyright 2021 en_US
dc.date.issued 2021-12-14
dc.identifier.uri http://hdl.handle.net/10725/13738
dc.description.abstract Lebanese cannabis is well-known for its high quality and recreational value; yet little is known regarding its medical use. Hyperthyroidism affects approximately 1%-2% of the world population. Limited literature is available on cannabis use on thyroid dysfunction. The present study aims to explore the antithyroid potential of Lebanese cannabis oil extract (COE) use in mice. Male BALB/c mice weighing between 31 and 35 grams were distributed into five groups of 14 mice each; group I served as control and was given a mixture of Ethanol: Cremophor: PBS (1:1:18) administered intra peritoneally (i.p.) for 35 days. To induce hyperthyroidism, group II was given levo- thyroxine (10μg) orally for 35 days; groups III, IV, and V were given levo- thyroxine (10μg) over 14 days and then treated with PTU (0.2mg/kg PO), COE (10mg/kg i.p.), and COE (20mg/kg i.p.), respectively over 21 days. The effect of COE on hyperthyroidism was assessed by measuring FT3, FT4 and TSH levels in mice blood. Mice liver and thyroid morphology was examined, as well. Results show that COE and PTU where equally effective in controlling FT3 levels in mice (P-value <0.001), but PTU was more potent than COE dose I and dose II in abating FT4 levels. Regarding thyroid and liver morphology, the group treated with COE dose II (group V) showed the lowest thyroid weight as compared to other treated groups (III, IV). To note, there was no observed difference in the liver morphology in any of the treated and control groups. In conclusion, the results assured that COE has dose/time dependent effect in lowering FT3 and FT4 thyroid hormones. Further studies are required to acknowledge the mechanism of action of COE antithyroid effect. en_US
dc.language.iso en en_US
dc.subject Cannabis -- Therapeutic use en_US
dc.subject Thyroid antagonists en_US
dc.subject Thyroid antagonists -- Physiological effect en_US
dc.subject Lebanese American University -- Dissertations en_US
dc.subject Dissertations, Academic en_US
dc.title Evaluation Of Anti Thyroid Activity of Cannabis Sativa Oil Extract Against Levothyroxine Induced Hyperthyroidism in Mice en_US
dc.type Thesis en_US
dc.term.submitted Fall en_US
dc.author.degree MS in Pharmaceutical Development And Management en_US
dc.author.school SOP en_US
dc.author.idnumber 201906032 en_US
dc.author.commembers Mroueh, Mohamad
dc.author.commembers Faour, Wissam
dc.author.department Pharmaceutical Sciences en_US
dc.description.physdesc 1 online resource (xii, 76 leaves): ill. (some col.) en_US
dc.author.advisor Saab, Yolande
dc.author.advisor Shebaby, Wassim
dc.keywords Thyroid Gland en_US
dc.keywords TSH en_US
dc.keywords FT4 en_US
dc.keywords FT3 en_US
dc.keywords CB1 Receptor en_US
dc.keywords CB2 Receptor en_US
dc.keywords Entourage Effect en_US
dc.keywords Cannabis Sativa en_US
dc.keywords Cannabinoids en_US
dc.keywords Levo-thyroxine Induced Hyperthyroidism en_US
dc.keywords PTU Standard Drug en_US
dc.description.bibliographiccitations Includes bibliographical references (leaf 68-74) en_US
dc.identifier.doi https://doi.org/10.26756/th.2023.573
dc.author.email daniaabida.alsayed@lau.edu en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php en_US
dc.publisher.institution Lebanese American University en_US
dc.author.affiliation Lebanese American University en_US

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